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Top 8 Best Dihydroberberine Supplements

Written by Andrew Le, MD

UpdatedSeptember 2, 2024

Dihydroberberine is a natural alkaloid originating from Berberis aristata and Berberis vulgaris plants. They have also been known to be used in the diet as supplements because of their perceived health benefits. Dihydroberberine has been described to possess antioxidant and anti-inflammatory effects as well as assist with controlling blood glucose and increasing insulin sensitivity.

When it comes to choosing the best dihydroberberine supplement it is good to note the following factors. The first consideration is to buy a good supplement from a well-known manufacturer. Also, search for products that have been tested by third parties as far as purity and potency are concerned.


Peak Performance Super Berberine Supplement

Editor's Choice

Peak Performance Super Berberine Supplement

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For those who are interested in the natural way of boosting metabolism, I highly recommend the Peak Performance Super Berberine Supplement.

Pros

  • With Dihydroberberine (DHB), this supplement is up to 5x more bioavailable and absorbable than regular berberine supplements.
  • Super Berberine may help increase plasma BHB ketones.
  • All ingredients are carefully chosen and 3rd party tested for purity.

Cons

  • The supplement may not be suitable for those with allergies to soy, milk, egg, shellfish, corn, wheat, or peanuts.
  • Some users may experience side effects such as chest tenderness or changes in menstrual cycles.
  • While it may help with cravings, it may not necessarily lead to weight loss.

We have been taking the Peak Performance Super Berberine Supplement for a few weeks now, and we have witnessed the improvements of our energy levels. We understand it is natural, vegan, and has no gluten and preservatives. This supplement is 5 times more effective than normal berberine supplements, which is another big bonus. As for the adverse reactions, we have not seen any yet, although it should be noted that it may not be safe for consumers with certain allergies/health issues. In conclusion, we fully endorse this supplement for any person seeking to support metabolism through natural means.


Peak Performance Ultra High Strength 4-In-1 Super Berberine Patented GlucoVantage® + Wild Bitter Melon + Cinnamon Extract + Chromium Picolinate Vegan Capsules

Peak Performance Ultra High Strength 4-In-1 Super Berberine Patented GlucoVantage® + Wild Bitter Melon + Cinnamon Extract + Chromium Picolinate Vegan Capsules

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This supplement is perfect for anyone wishing to enhance post-meal boosts and energy in the body naturally.

Pros

  • The patented GlucoVantage Dihydroberberine (DHB) is an active metabolite of berberine, which has been shown to be up to 5x more bioavailable/absorbable, and 2x longer-lasting than regular berberine.
  • Contains Cinnulin PF - a unique proprietary, patented cinnamon extract.
  • Natural ingredients that are carefully chosen and 3rd party tested for purity.

Cons

  • Some people may not like the taste of the supplement.
  • May not work for everyone.
  • May take some time to see results.

I have been taking the Peak Performance Ultra High Strength 4-In-1 Super Berberine Patented GlucoVantage® + Wild Bitter Melon + Cinnamon Extract + Chromium Picolinate Vegan Capsules for a few weeks now and have found an increase in my energy levels and better digestion. This supplement is made from natural ingredients that are selected and tested for quality and the fact that they are 3rd party tested for purity is actually a bonus for us. We also consider it noble that the supplement is vegan and does not include soy, milk, egg, shellfish, corn, wheat, and peanuts allergens.

As mentioned before, the key benefit of this supplement is the patented GlucoVantage Dihydroberberine (DHB), the active metabolite of berberine. DHB is 5x more bioavailable/absorbable than regular berberine and has a twice longer residence time in the bloodstream: 8 hours versus 4 hours. This suggests that the supplement is superior and more extended than other berberine supplements in the market.

Another remarkable component found in this supplement is Cinnulin PF, which is a special, patented cinnamon compound. Cinnamon has been found to have many health benefits, ranging from helping reduce blood sugar levels in the body to increasing the sensitivity of insulin. This supplement is great for after-meal spikes and energy and is even better because it now includes cinnamon.

All in all, we have had favorable experiences with this kind of supplement; however, it might not apply to everyone. Also, some may not like the taste of the supplement once they take it. Based on its contents and performance, we recommend this product to anyone who wants a natural solution to his or her digestion and energy requirements.


EPC ENDURANCE PRODUCTS COMPANY Dihydroberberine

EPC ENDURANCE PRODUCTS COMPANY Dihydroberberine

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If you’re seeking a very bioavailable form of berberine, EPC ENDURANCE PRODUCTS COMPANY Dihydroberberine may be of interest.

Pros

  • More bioavailable than regular berberine
  • Free of common allergens
  • Proprietary vegetable-based wax matrix for optimal absorption and maximum effectiveness

Cons

  • May cause digestive upset
  • Expensive compared to regular berberine
  • Some users may experience diarrhea

Recently, we decided to take the EPC ENDURANCE PRODUCTS COMPANY Dihydroberberine, and we appreciated its’ non-allergic and highly bioavailable nature. The wax matrix obtained from vegetables dissolves at body temperature and releases nutrients in a span of 5-7 hours, which is how our body processes food. This reduces side effects and adverse effects on the gut. We also enjoyed the fact that it has no common allergens and is suitable for vegans and vegetarians.

We did notice some gastrointestinal discomforts, which are seldom side effects of berberine supplements. Third, it is costlier compared to standard berberine supplements, which could be a problem for some people. Some users may also suffer from diarrhea and that is why a small dose should be used and periodically increased.

All things considered, we believe that EPC ENDURANCE PRODUCTS COMPANY Dihydroberberine is a very good supplement for anyone interested in a more absorbable form of berberine. However, it is not safe for everyone, so one should consult a physician before using it.


LongLifeNutri Berberine Supplement

LongLifeNutri Berberine Supplement

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LongLifeNutri Berberine Supplement is the best Berberine supplement on the market due to its high quality and all natural ingredients.

Pros

  • The Berberine supplement is made in the USA, and is non-GMO and vegan.
  • The supplement is sourced from Berberis Aristata Vulgaris, and contains 500mg of Berberine Hydrochloride per serving.
  • The supplement is free of fillers and comes with an exclusive LongLifeNutri Vitamin Case.

Cons

  • Some users may experience upset stomach or nausea when taking the supplement.
  • The supplement may not be suitable for those with certain medical conditions or who are taking certain medications.
  • The supplement may not be effective for everyone.

To our knowledge we have used the LongLifeNutri Berberine Supplement and can confirm it is a high quality supplement. It is rather convenient to use and tastes good. Since we have started using the supplement we have realized that our overall health has begun to improve in some ways.

Customer support for the supplement is also impressive, with LongLifeNutri available to assist at all hours of the day and night and offering the customer a lifetime money-back guarantee.

In conclusion, we highly recommend purchasing the LongLifeNutri Berberine Supplement for people who want to improve their health with a highly qualified natural supplement.


SugarMD Dr. Ergin's Super Berberine

SugarMD Dr. Ergin's Super Berberine

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We highly recommend SugarMD Dr. Ergin’s Super Berberine to anyone who is in the market for an organic supplement to manage their blood sugar levels and enhance their quality of life.

Pros

  • The blend is potent, unique, and specially formulated to help optimize your blood sugar levels.
  • Harness the power of Dihydroberberine (DHB) to get 5 times the bioactive advantages of regular berberine.
  • Doctor-formulated with expertly sourced ingredients to maximize the benefits.

Cons

  • The price is a bit high compared to other supplements on the market.
  • Some customers have reported that the product is not potent enough for their needs.
  • The number of capsules per bottle is relatively low.

For the past few weeks we have been trying SugarMD Dr. Ergin’s Super Berberine and we couldn’t be happier with the effects. The supplement comprises of plant extracts such as Barberry, Goldenseal, Oregon Grape, Coptis, Phellodendron and other natural components making it natural and an all round supplement. The regulation of blood sugar has been better and we also feel active and alert during the day.

The major constituent of this supplement is Dihydroberberine (DHB) which is five times more bioavailable than the normal berberine. This implies that we are receiving more of the bioactive benefits from the supplement for the overall welfare of the body.

One thing we like about SugarMD Dr. Ergin’s Super Berberine is that it is formulated and tested by a doctor and great care is taken to make it safe for human consumption. Thus, we are assured of the product’s effectiveness and safety, given that the ingredients were sourced well and the product was tested.

In conclusion, we fully endorse SugarMD Dr. Ergin’s Super Berberine for anyone seeking an effective dietary supplement to address the fluctuation of blood sugar levels and enhance their health.


SoActive® Berberine 550 mg: 9.6X Higher Absorption, Clinically Proven Most Effective Berberine - Optimized Berberine Phytosome | Clinically Validated Dose | Metabolism, Blood Sugar, AMPK | 60 Servings

SoActive® Berberine 550 mg: 9.6X Higher Absorption, Clinically Proven Most Effective Berberine - Optimized Berberine Phytosome | Clinically Validated Dose | Metabolism, Blood Sugar, AMPK | 60 Servings

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If you seek an easily absorbed and efficient dihydroberberine supplement, SoActive Berberine may be what you are looking for.

Pros

  • In a clinical trial, this Berberine phytosome was shown to have 9.6X (960%) higher absorption compared to standard Berberine.
  • SoActive Berberine is the most biologically active and effective form of Berberine that has been clinically shown to be optimally absorbed and utilized within the body.
  • SoActive Berberine has been clinically tested for health benefits and shown to optimize blood sugar, balance hormones, improve metabolic health, and improve acne.

Cons

  • While standard Berberine can often lead to stomach discomfort, SoActive Berberine is optimized for absorption and delivery and eliminates the frequent stomach discomfort associated with Berberine.
  • A dosage of 550 mg taken twice daily is clinically validated to deliver proven health benefits. However, some individuals may prefer a different dosage or frequency.
  • SoActive Berberine is a relatively new product, so there may not be as many reviews or long-term studies available as with other Berberine supplements.

We have been using SoActive Berberine for some weeks now, and we have observed improvements in our general health condition. The supplement is easy to take and does not cause any bad stomach feeling which is a big plus for me. We understand that the Berberine phytosome is readily bioavailable and has been clinically proven to be beneficial for regulating diabetes, hormonal imbalance, and other metabolic disorders.

All in all, we would fully testify to SoActive Berberine for anyone who is seeking the best Berberine supplement enhanced for bioavailability and backed up by research.


Dr. Whitaker’s Berberine GlucoGold Supplement

Dr. Whitaker’s Berberine GlucoGold Supplement

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If you are interested in finding a natural way to keep your blood sugar levels to normal, then we highly recommend the Dr. Whitaker’s Berberine GlucoGold Supplement.

Pros

  • The combination of BerberPure Berberine, Crominex 3+, Banaba leaf extract, and concentrated cinnamon extract make this supplement a powerhouse of natural ingredients.
  • The clear-coat tablets are easy to swallow and free of unnecessary colorants.
  • Developed by Julian Whitaker, MD, a pioneer of alternative medicine, and the Whitaker Nutrition research team, this supplement is distributed by Healthy Directions, known for its stringent quality control measures and Triple Testing Philosophy.

Cons

  • The price of this supplement is on the high end.
  • The tablets could be better coated to make them easier to swallow.
  • Some users reported an aftertaste.

For the past few weeks now, we have been taking Dr. Whitaker’s Berberine GlucoGold Supplement, and I have noticed a positive change in my blood sugar levels. It is safe to use this supplement because the ingredients used are natural and they are scientifically proven to work. The tablets are coated with a clear coat to ease swallowing; however, we perceived a faint taste in the throat. In conclusion, we highly recommend this supplement for those seeking a natural increase in insulin sensitivity.


NusaPure Berberine HCI 4500 mg - 200 Veggie Caps - 6 Months Supply

NusaPure Berberine HCI 4500 mg - 200 Veggie Caps - 6 Months Supply

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For a high-quality Berberine supplement, the NusaPure Berberine HCI 4500 mg is worth consideration.

Pros

  • Delivers the equivalence of 4,500 mg of Berberis Aristata root powder per capsule
  • 200 veggie caps for a 200 day supply
  • Non-GMO, gluten-free, and suitable for vegan and vegetarian diets

Cons

  • May take some time to see noticeable results
  • Some users have reported mild side effects such as stomach discomfort
  • Not suitable for pregnant or nursing women

NusaPure Berberine HCI 4500 mg is something that we have been taking for a few months now and the effects have been rather positive. The capsules are small and easy to swallow, and we are happy to see that the products are vegan and vegetarian-friendly.

A special characteristic of this supplement is that each capsule contains as much Berberis Aristata root powder, equivalent to 4,500 mg, which means it is a strong product. There have been reported changes in terms of the effects of this supplement on our blood sugar levels and energy levels.

However, the results can be different and it will take some days-week to look at the changes. Side effects are occasional and slight such as nausea; therefore, it is recommended to start with a small dose and build up gradually.

All in all, we strongly suggest the NusaPure Berberine HCI 4500 mg to anyone who is in the market for a good Berberine supplement.

Buying Guide

When selecting the right dihydroberberine supplement the following factors have to be considered so as to get the right supplement for your needs.

Purity and Quality

The quality and purity of the dihydroberberine supplement is thus the most crucial aspect to consider. It is recommended that one settles for a supplement that has quality ingredients in its formulation and that the supplement has been analyzed for purity. Select a product that has been produced in a facility that adheres to Good Manufacturing Practices (GMP) and has been accredited by an accrediting body.

Dosage and Potency

Another consideration is the dosage and the strength of the dihydroberberine supplement. Choose a product that contains enough dihydroberberine for the recommended serving size. The recommended dosage also depends on the person. Therefore, it is advisable to seek advice from qualified personnel before consuming any supplements.

Formulation

Specifically, the formulation of the dihydroberberine supplement may also affect its efficacy. The ideal supplement should incorporate the best formulation that has been developed to enhance the absorption and biological availabilities.

Price

Another consideration when selecting a dihydroberberine supplement is the price. When selecting the product, make sure that it is affordable but offers the best value for the amount of money to be spent. But at the same time, one should be wary of products that are very inexpensive because they are likely to be of inferior quality.

In light of these factors, it will be easier for you to identify the right dihydroberberine supplement that fits your needs and offers the greatest value.

Frequently Asked Questions

What is Dihydroberberine supplement?

Dihydroberberine, also known as DHB, is an isolated natural compound derived from the roots of certain plants. It is derived from berberine, an alkaloid supplement mostly used for various health purposes. It has been established that DHB possesses positive effects similar to those of berberine but with additional perks.

What are the benefits of Dihydroberberine supplements?

DHB is beneficial for health, especially for regulating blood glucose levels, reducing inflammation, and boosting energy levels. It has also demonstrated some positive effects concerning the process of the weight loss and cardiovascular health.

Is dihydroberberine better than berberine hydrochloride?

DHB and berberine hydrochloride have the same functionality, but DHB has certain benefits over berberine. DHB is more bioavailable, simply meaning that it is better absorbed into the body than berberine. It also has a longer half-life, which indicates that it remains within the body for a longer time and may be more suitable.

What is the most effective berberine supplement?

There are many good berberine supplements in the market today, but DHB is probably the best because its absorption rate as well as the half life is higher than that of other berberine supplements. However, in terms of efficacy, it must be noted that effectiveness of a supplement may differ from one user to the other based on his or her health requirements.

Dihydroberberine side effects

DHB is considered safe and non-toxic, however, some of the users may encounter mild side effects like mild nausea, stomach upset or mild head ache. Just like any supplement, consultation with a health care provider before taking DHB is advisable if one has other medical conditions or when taking other medicines.

Dihydroberberine dosage for weight loss

The recommended dose of DHB for weight loss has not been determined however, doses of DHB have ranged between 50mg and 300mg per day in the preceding research. The starting dose should be low and should be gradually escalated depending on the patient’s response and under the supervision of the practitioner.

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