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Top 8 Best L-Methylfolate Supplements

Written by Andrew Le, MD

UpdatedOctober 17, 2024

L-methylfolate is a form of folate which is a B-vitamin that is essential to the body’s metabolic process. It plays a critical role in the synthesis of DNA and RNA as well as the generation of red blood cells and proper functioning of the human nervous system. Folate is present in many foods; however, some individuals require supplementation since they are unable to properly absorb or metabolise the vitamin.

L-methylfolate comes in tablets, capsules, available as well in the powdered from. They can be also widely used for maintaining mental health since, for instance, L-methylfolate can be beneficial for increasing the mood and lessening symptoms of depression. also, dependent on some genetic mutations of folate metabolism can benefit from supplementation with L-methylfolate.

While choosing L-methylfolate supplements, certain elements such as strength and type of the complement, and the quality of the product should be put into consideration. Intake of L-methylfolate also must be moderated because both in excessive amounts and deficiency are dangerous for a human body. Another factor which is important is the form of the supplement, preferably having the form of a capsule or a tablet which is pleasant to take and assimilate. , yet quality is important, as some of the supplements may contain substances which are detrimental to human health.

We invested our time in researching and comparing many L-methylfolate supplements in order to determine which are the most effective. In the next parts of this guide, you will find out what we consider to be the best online proofreading tools and a deep description of each of them.

Top 3 Best L-Methylfolate Supplements

  1. Nutricost Methylfolate 1000mcg
  2. NatureBell L Methylfolate 15mg (5-MTHF) with Methyl B12 1,000mcg
  3. Life Extension Optimized Folate (L-Methylfolate)

The following is a list of the top L-Methylfolate supplements that we have taken our time to analyze and come up with the best option for your health. L-Methylfolate, or 5-MTHF, is bioactive form of folate that is involved in numerous processes in the human body such as cell division, building of DNA, creation of proteins, and synthesis of neurotransmitter. No matter if you want to improve your overall health or are in search of a way to successfully treat and/or mitigate a certain type of disease – we’ve readily present the best L-Methylfolate supplements for your consideration.


Nutricost Methylfolate 1000mcg

Editor's Choice

Nutricost Methylfolate 1000mcg

We’ve been using Nutricost Methylfolate 1000mcg and have noticed a boost in energy and overall well-being. With its high potency and dietary-friendly formula, it’s perfect for those needing a substantial folate intake. Just be cautious if you have a sensitive stomach. Overall, it's a top choice for enhancing cognitive and general health.

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If you are looking for the best L-methylfolate supplement, then Nutricost Methylfolate 1000mcg might be perfect for you.

Pros

  • High-potency 1000mcg dosage
  • Supports cognitive function and mood
  • Gluten-free, Non-GMO, and vegetarian capsules
  • Easy to swallow

Cons

  • Higher dose may not be necessary for everyone
  • Some may experience mild gastrointestinal discomfort

We have tried Nutricost Methylfolate 1000mcg for quite some time now and saw that it had a beneficial effect on energy levels and well-being. The dosage of 1000mcg is ideal for people who want a massive daily intake of folate or have certain health concerns or conditions. It is gluten-free, Non-GMO, and the product is available in vegetarian capsules, which makes it friendly to a number of dietary needs.

On the negative side, the high potency may be more than what some people needs and some of us felt a slight stomach discomfort when taken on an empty stomach.

Nevertheless, Nutricost Methylfolate is among the best L-methylfolate supplement available out there in the market. If you are in search of a reliable supplement that can help improve your cognitive abilities and general health, then getting yourself a bottle of Nutricost Methylfolate 1000mcg would not be a bad decision.


NatureBell L Methylfolate 15mg (5-MTHF) with Methyl B12 1,000mcg, 240 Vegetarian Capsules

NatureBell L Methylfolate 15mg (5-MTHF) with Methyl B12 1,000mcg, 240 Vegetarian Capsules

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I highly recommend NatureBell L Methylfolate 15mg (5-MTHF) with Methyl B12 1,000mcg, 240 Vegetarian Capsules if you are searching for a premium quality L-methylfolate supplement.

Pros

  • Dual action: Methyl Folate 15mg and Vitamin B12 for enhanced energy and cognitive support.
  • Easily absorbed: Active Folic Acid - L-methylfolate for maximum benefits in mental clarity, cognitive function, prenatal health.
  • High quantity: 240 Vegetarian Capsules for a 4-month supply of premium quality, gluten-free, non-GMO vegetarian capsules, suitable for those with dietary restrictions.

Cons

  • Some users may experience stomach discomfort when taking it without food.
  • The capsules may be too large for some people to swallow.
  • It may not work for everyone.

NatureBell L Methylfolate 15mg (5-MTHF) with Methyl B12 1,000mcg, 240 Vegetarian Capsules is a potent formula of Methyl Folate and Vitamin B12 supplement beneficial to one’s health. They include normal energy metabolism, combating fatigue, and maintaining the health of the nervous system for enhanced brain performance and concentration.

The active Folic Acid – L-methylfolate is smoothly absorbed to give its optimal values on mental clarity, and cognitive as well as prenatal performance. This supplement is 3rd party tested to guarantee the best quality, and the ingredients used are pure to give you the best supplement.

The 240 Vegetarian Capsules are ideal as they offer a 4 Months’ pack with each being of premium and gluten-free, non-GMO vegetarian quality for the restricted diet consumers. However, some individuals may experience nausea in the stomach when they take the drug without food as well as the fact that capsules may be rather large for most people to swallow. Besides, it is not suitable for everyone.

All in all, if you are searching for a fantastic L-methylfolate supplement that helps both L-methylfolate and is ease to intake, then NatureBell L Methylfolate 15mg (5-MTHF) with Methyl B12 1,000mcg, 240 Vegetarian Capsules is a superb choice to make.


Life Extension Optimized Folate (L-Methylfolate)

Life Extension Optimized Folate (L-Methylfolate)

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For the best L-Methylfolate supplement that is really highly considered, Life Extension Optimized Folate may not be bad for you.

Pros

  • Provides 1700 mcg of 5-MTHF, the metabolically active form of folic acid
  • Supports both cardiovascular and cognitive health
  • Non-GMO, gluten-free, and vegetarian

Cons

  • Some people may find the price to be a bit high compared to other supplements
  • The tablets are quite small, which may make them difficult to handle for some users
  • Some users may experience mild side effects like headaches or stomach upset

For the few months now we have been using the Life Extension Optimized Folate and we are not disappointed. This supplement delivers a large amount of 5-MTHF which is 5-7 times the bioequivalent of standard folic acid. This makes it a good complement for anyone working to achieve the right homocysteine levels and have a healthy heart and brain.

There is one aspect that we like most about this supplement and it’s the raw materials used in formulating this supplement are top notch. Most of the Life Extensionists products are non-GMO and free from gluten and or wheat and are made in the USA allowing me to feel secure knowing I am using quality product.

With that said, there is a slight concern regarding the cost of Life Extension Optimized Folate since it is relatively on the expensive side than any other supplement. However, we would like to point, that in our view the quality of the final product completely corresponds to the cost. Furthermore, the tablets could also be considered compact by users which would perhaps present handling issues.

All in all, Life Extension Optimized Folate is one of the best supplements that can be used by anyone wishing to promote cardiovascular and neurological health in themselves with the help of a premium-quality L-Methylfolate product.


DEAL SUPPLEMENT L Methylfolate Supplement

DEAL SUPPLEMENT L Methylfolate Supplement

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The DEAL SUPPLEMENT L Methylfolate Supplement is one of the best supplements we urge all those who want to boost prenatal development, brain activity, energy generation, and cellular integrity to consider.

Pros

  • The supplement contains top grade methyl folate (5-MTHF) in vegetarian capsules, making it a great option for those who are vegetarian or vegan.
  • Taking methyl folate on a regular basis may effectively replenish low B vitamin levels for both men and women.
  • The supplement is made with non-GMO ingredients and is free from gluten, dairy, eggs, peanuts, soy, wheat, yeast, and tree nuts.

Cons

  • The serving size is two veg capsules, which may be inconvenient for some users.
  • The supplement may take two to four weeks to fully see any effects.
  • Some users may find the price to be slightly higher compared to other L methylfolate supplements on the market.

For a few weeks now we have been using the DEAL SUPPLEMENT L Methylfolate Supplement and we have observed an increased energy level with general vitality. This supplement is very convenient and does not make the person taking it feel that they want to spit it out because of the flavor or stench.

The dosage and servings are also appropriate; the bottles contain 240 vegetable capsules, and each serving holds 15mg of L-Methylfolate from 25,000mcg of dietary folate equivalent; it comes in up to a 120-serving bottle, or a 4 months’ supply.

All in all, we strongly suggest that anyone in the market for a potent absorbable and methylated folate supplement turn to the DEAL SUPPLEMENT L Methylfolate Supplement.


Carlyle L Methylfolate Supplement

Carlyle L Methylfolate Supplement

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The Carlyle L Methylfolate Supplement is the best supplement that we have come across and we highly recommend it for those interested in improving their overall health.

Pros

  • The metabolically active form of Folic Acid, L-Methylfolate, delivers 25,000 mcg of Folate per serving, making it an excellent source of this essential nutrient.
  • The complete formula of quick-release capsules ensures that the supplement is easily absorbed and utilized by the body.
  • Carlyle is a trusted brand that is committed to providing premium, honest supplements to support healthy living.

Cons

  • The high dosage of Folate per serving may not be suitable for everyone, and it is important to consult with a healthcare professional before starting any new supplement regimen.
  • The capsules may be difficult to swallow for some individuals.
  • The supplement may not be suitable for those with certain medical conditions or who are taking certain medications.

The Carlyle L Methylfolate Supplement is an excellent supplement to take regarding health and fitness, particularly since it is made from natural ingredients. Thus the said supplement provides Folate in its active form as L-Methylfolate thus making this supplement rich in Folate. It is quick-release capsules, therefore it implies that the supplement is easily absorbed and works or is used to the maximum in the body.

Carlyle is a brand that people can trust which offers premium and genuine supplements for a healthy lifestyle. Usual common allergens such as Gluten, Wheat, Yeast, Lactose, and Soy are also absent from the supplement together with artificial flavors, preservatives besides being Non-GMO making the supplement safe and healthy for any believer of Folate supplement.

Although, the recommended dosage of Folate in a serving is quite high, this can easily be managed especially in occasions where the dosage is too much for the individual, it is advised that the individual should consult a healthcare provider before taking any new supplements. Furthermore, the capsules may be problematic and hard to ingest especially with the present health conditions of some people, the supplement may be unsuitable to some people with certain medical conditions or those who are on certain type of medications.

All in all, we give a nod to Carlyle L for this Methylfolate Supplement; its effectiveness and quality warrants a place in one’s regimen for their all-around well-being.


Nutri 5-MTHF L Methylfolate 15MG

Nutri 5-MTHF L Methylfolate 15MG

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Nutri 5-MTHF L Methylfolate 15MG is a highly potent supplement for those among you, who seek the most effective L-methylfolate out there.

Pros

  • This supplement delivers an impressive 15 MG per serving, giving you the advantage of a potent and highly effective formula.
  • Each bottle contains a generous supply of 120 vegan tablets, providing you with long-lasting support.
  • Our 5-MTHF supplement features the bioactive form of folic acid, known as 5-methyltetrahydrofolate (5-MTHF).

Cons

  • The tablets are quite small and may be difficult to handle for some people.
  • The price point may be higher than other L-methylfolate supplements on the market.
  • Some users may experience mild side effects such as headaches or nausea.

I have been taking Nutri 5-MTHF L Methylfolate 15MG for several weeks now and have seen an enhancement in my power and thinking capacity. The tablets have a test of ease in swallowing and actually do not have a very bad taste or smell. It is also important to note that this supplement contains no animal-based ingredients, so it is suitable for vegans and those who avoid animal-derived products.

As for the effectiveness, we have realized that we get into better moods and have less anxiety when taking this supplement. We also acknowledge that it favors the proper degree of methylation that is crucial for regulating homocysteine, supporting the cardiovascular system, and the brain.

In conclusion, if you are in the market looking for the best L-methylfolate supplement that offers great support to your body and process of methylation, Nutri 5-MTHF L Methylfolate 15MG is the real deal that you should try.


Zenavea L-Methylfolate Supplement

Zenavea L-Methylfolate Supplement

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We suggest the Zenavea L-Methylfolate Supplement to be purchased for those people who are searching for an effective and cheap way to treat the folate deficiency.

Pros

  • The Zenavea L-Methylfolate Supplement offers great value with 120 capsules and 15mg of L-5-MTHF per capsule, the most on the market and the recommended dose.
  • The optimized formula of this supplement ensures the best results, and it is non-bioengineered and contains NO GMO, NO allergens (no fish, no egg, no milk, no soy, no gluten, no sugar, no wheat, and so on).
  • This supplement helps support the synthesis of molecules, which is important for people with folate deficiency.

Cons

  • Some users may experience mild side effects such as nausea, headaches, or stomach discomfort.
  • The capsules may be difficult to swallow for some users.
  • This supplement may not be suitable for pregnant women or those who are nursing.

For the best and effective supplement of L-Methylfolate that is safe, the Zenavea L-Methylfolate Supplement is the best option. To enhance its potency and efficacy it is manufactured under an optimized formula and is allergen-free and GMO-free.

The Zenavea L-Methylfolate Supplement is ideal if you are among the people who lack folates due to your diet; it assists in the formation and modification of essential molecules. Minor side effects are reported in few users though the advantages that comes with the use of this supplement makes the vice less of the virtue.

All in all, Zenavea L-Methylfolate Supplement is one of the best L-Methylfolate supplements that you can use if you want to get optimum health benefits within your pocket.


Metabolic Maintenance L-Methylfolate 5mg

Metabolic Maintenance L-Methylfolate 5mg

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For people who are interested in obtaining a highly bioavailable form of folate that can help in nerve, cardiovascular, and mood maintenance, we suggest the Metabolic Maintenance L-Methylfolate 5mg supplement.

Pros

  • The supplement is free of fillers, binders, preservatives, and artificial colors and flavors.
  • It is a more active, bioavailable form of folate that can cross the blood-brain barrier.
  • Methylated folate can support the production of neurotransmitters serotonin, norepinephrine, and dopamine.

Cons

  • The supplement is a bit expensive compared to other options in the market.
  • Some people may experience mild digestive discomfort when taking the supplement.
  • The supplement is only available in capsule form, which may be difficult for some people to swallow.

The Metabolic Maintenance L-Methylfolate 5mg supplement can be taken by anyone who has a lower capability of converting folic acid into 5- MTHFR, the active form of folate. The supplement has methylated B vitamins that include L-methyl folate which can contribute to direct vitamin intake and guaranteed mood boosting.

Another advantage that can be noticed regarding this supplement is that this product does not contain any sorts of additives such as fillers, binders, preservatives or artificial colors and flavors. This means that you are getting a pure and high quality of methylated folate which can improve your health status in numerous ways.

Another good thing about this supplement is that it is a more efficient and active form of folate that can pass through the blood-brain barrier. This makes it a good supplement for those in search of a product that will help enhance the functions of the brain.

Buying Guide

When looking for the best L-methylfolate supplement, there are several factors to consider. Here are some key features to look for when selecting a product:

Dosage

The dosage of L-methylfolate is also one of the several concerns that should be looked at. The servings suggestions for L-methylfolate depend with the person’s needs but they usually range from 400-1000mcg in a day. Therefore, it is necessary to look at the amount of nutrients offered by the supplement as these are key to supporting the characteristic.

Purity

The supplement is L-methylfolate, and the purity of this supplement is also something of consideration. It is recommended to find a product without any additives where L-methylfolate is a main and only ingredient. It is also relevant to point out that it’s necessary to purchase the given product without traces of contamination and containing no chemicals or any other impurities while being reliable and of high quality in terms of tests and experiments.

Absorption

This is because very minimal amount of L-methylfolate is absorbed when ingested, according to available research. Search for an L-methylfolate that is bioavaliable, meaning it can be directly taken into the bloodstream. There are different forms of L-methylfolate in the market while only certain formulations are absorbed well by the body.

Price

Another thing to consider when selecting an L-methylfolate supplement is the price. There is need to look for a high quality product But that should not be absolute; one also needs to look for a product that they can afford to buy. It is advised to compare the prices as well as to seek for some sort of offer or a discount in order to utilize the money and purchase a product that would be valuable to use.

Frequently Asked Questions

What is the recommended daily dosage for L-methylfolate supplements?

The suggested servings concerning L-methylfolate supplements depend on different factors, and they are as follows. It has been observed that, the safe and efficacious dose of the drug is in the range of 1-2 milligrams per day. Nevertheless, one should not forget to seek advice from a health care provider in matters concerning the use of the given supplements.

What are the differences between L-methylfolate and folic acid supplements?

L-methylfolate and folic acid are two types of vitamin B9 but they differ in composition and the processing that occurs in the body. Thus, L-methylfolate is the active form of folate which may be used by the body while folic acid that is commonly supplemented requires conversion to L-methylfolate before it is active. Further, there are some individuals who have problems with the conversion of folic acid into L-methylfolate and in this group L-methylfolate is better to take.

What are the benefits of taking L-methylfolate supplements?

L-methylfolate supplements that may have various benefits, such as enhancing the oxidant’s proper brain function, alleviating mood swings, decreasing inflammation levels, and boosting the oxidant’s cardiovascular health. Further, there is also the contribution that L-methylfolate might be more helpful when taken by those people who genetically have the problems with legs metabolism of folate.

Are there any potential side effects of taking L-methylfolate supplements?

L-methylfolate supplements are relatively safe and do not pose serious side effects in most cases. Nonetheless occasionally some people can feel nausea or have a stomach upset or even some headaches. As always, it is recommended that any change in supplement intake should be first discussed with a doctor.

Which brands offer the best L-methylfolate supplements?

Some of the most recognized manufacturers of this supplement are Thorne, Jarrow Formulas, and Pure Encapsulations. Therefore, it’s necessary to select a brand that incorporates quality ingredients and a favorable reputation among consumers.

Can over-the-counter L-methylfolate supplements be as effective as prescription ones?

It is true that you can obtain L-methylfolate in the form of an over-the-counter supplement, which can work as well as a prescription one. But, one should choose the best supplement of a right brand and should not exceed the quantity recommended for the intake. It is also recommended to see a doctor before starting to take new supplements and introducing them into one’s diet.

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