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Top 8 Best Methylfolate Supplements for MTHFR

UpdatedOctober 23, 2024

Methylfolate supplements have become increasingly popular in recent years due to their potential health benefits. Specifically, those with an MTHFR gene mutation may benefit from taking methylfolate supplements to support their body's ability to process folate.

When it comes to choosing the best methylfolate supplement for MTHFR, there are a few critical factors to consider. First and foremost, it's essential to choose a supplement that contains the active form of folate, which is L-methylfolate. Additionally, the dosage and form of the supplement (such as capsules or tablets) should be taken into account.

At our team, we understand the importance of finding the right methylfolate supplement for MTHFR. That's why we spent countless hours researching and testing various supplements to identify the best options on the market. In the following sections, we'll share our top picks and provide in-depth reviews to help you make an informed decision.

Top 3 Best Methylfolate Supplements for MTHFR

  1. Nature's Fusions Methylated Folate Supplement
  2. Mama's Select Methylfolate MTHFR Folate
  3. Codeage Methylfolate B Complex Supplements

We have researched and tested various methylfolate supplements to help those with MTHFR gene mutations. Methylfolate is essential for the body to properly process homocysteine, an amino acid that can build up and lead to health problems. We understand the importance of finding the right supplement to support your health needs, which is why we have compiled a list of the best methylfolate supplements for MTHFR. Our recommendations are based on factors such as effectiveness, purity, and customer reviews.


Nature's Fusions Methylated Folate Supplement

Editor's Choice

Nature's Fusions Methylated Folate Supplement

Nature's Fusions Methylated Folate Supplement promotes optimal methylation, vital for cardiovascular and cognitive health. Third-party lab tested in the USA, it ensures purity. Nutri's satisfaction guarantee offers peace of mind.

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We highly recommend the Nature's Fusions Methylated Folate Supplement for those looking to optimize their well-being with a bioavailable and pure form of folate.

Pros

  • The 15mg per serving is a superior strength and highly effective formula for optimal support of your body's methylation processes.
  • The 120 vegan tablets per bottle provide a generous supply and cater to specific dietary preferences while offering maximum efficacy.
  • The bioactive form of folic acid, 5-methyltetrahydrofolate (5-MTHF), is highly bioavailable and pure, ensuring efficient absorption and utilization.

Cons

  • The tablets may be small and uncoated, which may make them difficult to swallow for some individuals.
  • The price point may be higher compared to other methylfolate supplements on the market.
  • The supplement may not be suitable for individuals with certain medical conditions or taking certain medications, so it is important to consult with a healthcare provider before use.

We have personally experienced the benefits of the Nature's Fusions Methylated Folate Supplement, including improved energy levels, cognitive function, and overall well-being. The supplement supports optimal methylation, which is crucial for maintaining healthy homocysteine levels, promoting cardiovascular wellness, and supporting cognitive function.

The 5-MTHF supplement is 3rd party lab tested in the USA, ensuring purity and quality. The satisfaction guarantee from Nutri also provides peace of mind for those looking to try the supplement.

In conclusion, if you are looking for a high-quality methylfolate supplement to support your overall well-being and methylation processes, we highly recommend the Nature's Fusions Methylated Folate Supplement.


Mama's Select Methylfolate MTHFR Folate

Mama's Select Methylfolate MTHFR Folate

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If you're looking for a highly bioavailable and superior methylfolate supplement for MTHFR gene mutation, Mama's Select Methylfolate MTHFR Folate is a great option to consider.

Pros

  • Formulated for pregnant and lactating mothers
  • Superior Methylfolate formula on the market
  • Supports fetal development including brain development, healthy cell growth, and spinal development

Cons

  • Large capsule size
  • May cause mild digestive discomfort
  • Only 90 capsules per bottle

We've been using Mama's Select Methylfolate MTHFR Folate for several months now and have noticed a significant improvement in our overall energy levels and mood. The formula is specifically designed for pregnant and lactating mothers, so we feel confident that we're getting the best possible nutrients for our growing baby.

One of the biggest pros of this product is the superior Methylfolate formula, which is made with 5-Methyltetrahydrofolate Calcium L-5 (6S). This gives you the highest quality methylfolate on the market, making it a great choice for those with MTHFR gene mutations.

In addition to supporting fetal development, Mama's Select Methylfolate MTHFR Folate is also a great folate supplement for women in general. It includes absolutely no maltodextrin, corn syrup solids, fillers, or genetically modified organisms (GMOs), so we feel confident that we're getting a pure and high-quality product.

One potential downside of this product is the large capsule size, which may be difficult for some people to swallow. Additionally, we've noticed some mild digestive discomfort after taking the supplement, although this has not been a major issue for us. Finally, the bottle only contains 90 capsules, which may not last as long as other supplements on the market.

Overall, we highly recommend Mama's Select Methylfolate MTHFR Folate for anyone looking for a high-quality methylfolate supplement. It's specifically formulated for pregnant and lactating mothers, and the superior formula ensures that you're getting the best possible nutrients for you and your baby.


Codeage Methylfolate B Complex Supplements

Codeage Methylfolate B Complex Supplements

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We highly recommend the Codeage Methylfolate B Complex Supplements for those looking for an all-in-one methylation supplement with folate, methylated vitamins, riboflavin, and betaine in an easy-to-use capsule format.

Pros

  • The supplement offers an all-in-one methylation supplement with folate, methylated vitamins, riboflavin, and betaine in an easy-to-use capsule format.
  • The formula contains 1360 mcg of 5- MTHF folate with Quatrefolic 5 methylfolate and glucosamine salt as a folate supplement. It also contains 30 mg of Riboflavin 5’- Phosphate as a riboflavin supplement.
  • The blend features 600 mg of betaine as trimethylglycine (TMG). The vitamins included in this formula (vitamin B6 and vitamin B12 1000 mcg) are also provided in their phosphorylated forms.

Cons

  • The supplement may cause nausea if taken before a meal.
  • The product may not be suitable for those with an egg allergy.
  • The price is on the higher side.

Codeage Methylfolate B Complex Supplements is a vegan, gluten-free, non-GMO supplement that is made in the USA. This formula is also dairy and soy-free. Codeage methylated vitamins capsules are manufactured in the USA in a cGMP certified facility and third party tested. It provides an active, methylated form of folate and vitamins B2, B6, B12 (5-MTHF and methylcobalamin B12).

We have personally used this supplement and noticed a significant increase in our energy levels. The supplement is easy to take and does not have a strong taste or smell. We highly recommend this supplement for those looking for a comprehensive methylation supplement.


Metabolic Maintenance L-Methylfolate 5mg

Metabolic Maintenance L-Methylfolate 5mg

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We highly recommend this product for anyone looking for a high-quality methylfolate supplement to support their cognitive and overall health.

Pros

  • Take The Right Kind Of Folate - Our bodies have a reduced ability to convert folic acid to 5-MTHF, the activated form of folate. This supplement provides the bioavailable form of folate, L-Methylfolate, for direct absorption and support.
  • Bioavailable Mood Support - L-Methylfolate is the only form of folate to cross the blood-brain barrier, making it a more active and effective brain supplement for mood support.
  • Cardiovascular, Nerve, & Mood Support - Methylated folate is essential for the production of neurotransmitters like serotonin, norepinephrine, and dopamine, as well as overall nerve and cardiovascular maintenance.

Cons

  • Capsule Size - Some users may find the capsule size to be larger than they prefer.
  • Price - This product is a bit more expensive compared to other methylfolate supplements on the market.
  • Dosage - The recommended dosage is 1 capsule per day, which may not be enough for some individuals who require a higher dose.

This supplement is a great choice for anyone looking for a high-quality, physician-recommended methylfolate supplement. The product is free of fillers, binders, preservatives, and artificial colors and flavors, making it a pure and potent supplement. We appreciate the company's commitment to quality and purity, as well as their use of third-party testing to ensure the efficacy of their products.

The supplement is easy to take and has no unpleasant aftertaste or side effects. We have noticed improved mood and cognitive function since starting to take this supplement. The product is also vegetarian and gluten-free, making it suitable for a wide range of dietary needs.

Overall, we highly recommend this product for anyone looking for a high-quality methylfolate supplement to support their cognitive and overall health.


MD.LIFE L-Methylfolate 7.5 mg - Active Folate 5 Mthfr Support Supplement Professional Strength Methyl Folate - Essential Amino Acids & Brain Supplement- 30 Vegan Capsules 30 Count (Pack of 1)

MD.LIFE L-Methylfolate 7.5 mg - Active Folate 5 Mthfr Support Supplement Professional Strength Methyl Folate - Essential Amino Acids & Brain Supplement- 30 Vegan Capsules 30 Count (Pack of 1)

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If you're looking for a reliable methylfolate supplement for MTHFR, MD.LIFE L-Methylfolate 7.5 mg is a great option.

Pros

  • This supplement contains active folate that works by providing your body with the necessary ingredients to properly utilize folic acid.
  • Methylfolate 7.5 mg is essential for the production and maintenance of new cells, making it a great choice for those looking for synthesis and repair support.
  • This supplement is third-party tested for purity, ensuring the highest level of quality and compliance with safety and performance standards.

Cons

  • The unflavored capsule may be difficult to swallow for some.
  • Some users may experience mild side effects such as nausea or headaches.
  • This supplement may not be suitable for those with certain medical conditions or taking certain medications.

We've had a positive experience with MD.LIFE L-Methylfolate 7.5 mg. The active folate in this supplement has helped us feel more energized and focused, while also supporting our mood and hormone levels. We appreciate that this product is third-party tested for purity, giving us peace of mind about the quality of the supplement. However, we do wish that the capsule was easier to swallow and that the supplement was more suitable for those with medical conditions or taking certain medications. Overall, we would recommend MD.LIFE L-Methylfolate 7.5 mg to anyone looking for a reliable methylfolate supplement for MTHFR.


NatureGenX Methylation Protect w/Active B12 with L-5-MTHF for MTHFR Support Supplement, Natural Cherry Methylfolate B12 Sublingual, Gluten-Free (60 Tables)

NatureGenX Methylation Protect w/Active B12 with L-5-MTHF for MTHFR Support Supplement, Natural Cherry Methylfolate B12 Sublingual, Gluten-Free (60 Tables)

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If you want a natural and effective supplement for MTHFR support, NatureGenX Methylation Protect w/Active B12 with L-5-MTHF is the way to go.

Pros

  • Provides the most stable, bioavailable, and active form of folate and vitamin B12
  • Ideal for those with MTHFR Gene Mutation
  • Boosts your energy and supports complete cellular health

Cons

  • The taste may not be for everyone
  • May not work for everyone
  • A bit pricey

This supplement is designed to help you be your best self every day by boosting your focus, energy, and healthy adrenal function. The MTHFR gene is responsible for how much methylfolate is produced in the body, and this supplement is ideal for those with MTHFR Gene Mutation. Attaching methyl groups to a compound protects that compound from damage and helps support the production of new compounds in the body, promoting complete cellular health, mood balance, and cardiovascular health.

NatureGenX Methylation Protect w/Active B12 with L-5-MTHF 1000 mcg does not have to be converted, so it starts working immediately, making Methylcobalamin the most stable and bioavailable form of vitamin B12 to boost your energy. These nutrients are part of a unique formula and work together to achieve optimal total-body health. Our B12 and folate supplements are gluten-free and free of artificial colors and flavors. Quality and based in the USA.

In conclusion, if you're looking for a natural and effective supplement for MTHFR support, NatureGenX Methylation Protect w/Active B12 with L-5-MTHF is definitely worth considering. It provides the most stable, bioavailable, and active form of folate and vitamin B12, and it's ideal for those with MTHFR Gene Mutation.


MD.LIFE L-Methylfolate 5 mg

MD.LIFE L-Methylfolate 5 mg

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If you're looking for a potent methylfolate supplement to support your mood, brain, and overall health, MD.LIFE L-Methylfolate 5 mg is worth considering.

Pros

  • This supplement contains active folate that works effectively without the need for the MTHFR enzyme.
  • Methylfolate 5 mg is essential for the production and maintenance of new cells, making it great for synthesis and repair.
  • MD.LIFE L-Methylfolate 5 mg is third-party tested for purity, ensuring the highest level of quality and safety.

Cons

  • The capsules are unflavored, which may not be appealing to some users.
  • This supplement contains a high dose of methylfolate, which may not be suitable for everyone.
  • Some users may experience mild side effects such as nausea or headaches.

We've been using MD.LIFE L-Methylfolate 5 mg for a few weeks now, and we've noticed some positive changes in our mood and energy levels. The capsules are easy to swallow, and we appreciate that the product is made and packaged in the USA.

If you're looking for a professional-strength methylfolate supplement to support your overall health, we recommend giving MD.LIFE L-Methylfolate 5 mg a try. However, we suggest consulting with your healthcare provider before adding any new supplements to your routine.


Intelligent Labs 1MG 5-MTHF Methylfolate

Intelligent Labs 1MG 5-MTHF Methylfolate

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If you're looking for a high-quality methylfolate supplement for MTHFR, we highly recommend Intelligent Labs 1MG 5-MTHF Methylfolate.

Pros

  • Pure 5-MTHF for MTHFR issues
  • 4th generation activated folate for better absorption
  • Quatrefolic acid for trademarked supplement 5-MTHF

Cons

  • Capsules may vary in fill levels
  • May not work for everyone
  • Some users may experience side effects

We have personally used this supplement and have noticed significant improvements in our energy levels and overall well-being. The pure 5-MTHF and 4th generation activated folate make it an excellent choice for those with MTHFR issues. The Quatrefolic acid is a trademarked supplement that is chemically similar to metafolin or l-methylfolate calcium, but the methylfolate is bound to glucosamine instead of calcium, making it better absorbed by the body.

One potential downside is that the capsules may vary in fill levels, which can affect the dosage. Additionally, not everyone may experience the same benefits, and some users may experience side effects such as headaches or nausea.

Overall, we highly recommend Intelligent Labs 1MG 5-MTHF Methylfolate for anyone looking for a high-quality methylfolate supplement for MTHFR. With 120 capsules per bottle and a 4-month supply, it's an excellent value for your money. Plus, you can rest assured that you're getting a pure and high-quality supplement that is manufactured in an NSF GMP recognized facility in the United States.

Buying Guide

When choosing the best methylfolate supplement for MTHFR, there are a few things to consider to ensure you are getting a high-quality product that meets your needs. Here are some factors to keep in mind when making your selection:

Form of Methylfolate

Methylfolate supplements come in different forms, including capsules, tablets, and powders. Capsules and tablets are the most common forms, and they are easy to take and convenient for on-the-go use. Powders can be mixed with water or other liquids, which may be a good option for those who have difficulty swallowing pills. Consider your personal preference and lifestyle when choosing the form of methylfolate that works best for you.

Dosage

The dosage of methylfolate supplements can vary widely, so it's important to choose a product that provides the right amount for your needs. The recommended dosage will depend on factors such as age, sex, and health status. Be sure to consult with a healthcare professional to determine the appropriate dosage for you.

Quality and Purity

It's important to choose a methylfolate supplement that is high-quality and pure. Look for products that are made by reputable manufacturers and have undergone third-party testing to verify their purity and potency. You can also check for certifications such as Good Manufacturing Practices (GMP) to ensure that the product meets strict quality standards.

Other Ingredients

Check the label for any other ingredients in the supplement, such as fillers, binders, or artificial colors and flavors. Some people may have sensitivities or allergies to certain ingredients, so it's important to choose a product that is free from any potential allergens or irritants.

Price

Methylfolate supplements can vary in price, so it's important to consider your budget when making your selection. Keep in mind that higher-priced products may not necessarily be of higher quality, so be sure to do your research and compare products to find the best value for your money.

By considering these factors, you can choose a high-quality methylfolate supplement that meets your needs and supports your health.

Frequently Asked Questions

What is the recommended dosage of methylfolate for MTHFR mutation?

The recommended dosage of methylfolate for MTHFR mutation varies depending on the severity of the mutation. It is best to consult with a healthcare professional to determine the appropriate dosage.

What are the benefits of taking a 5-MTHF supplement?

Taking a 5-MTHF supplement can help support healthy methylation and DNA synthesis. It may also help improve mood and cognitive function.

Can individuals with MTHFR gene mutation take methylfolate?

Yes, individuals with MTHFR gene mutation can take methylfolate. In fact, it is often recommended as a way to support healthy methylation.

What is the difference between L-5-Methyltetrahydrofolate and folic acid?

L-5-Methyltetrahydrofolate is the active form of folate that the body can readily use. Folic acid, on the other hand, needs to be converted into L-5-Methyltetrahydrofolate before the body can use it.

Are there any recommended multivitamins for individuals with MTHFR mutation?

There are various multivitamins available that are specifically formulated for individuals with MTHFR mutation. It is important to look for a multivitamin that contains the active form of folate, such as L-5-Methyltetrahydrofolate.

What are the benefits of taking L-5-Methyltetrahydrofolate over L-Methylfolate?

L-5-Methyltetrahydrofolate is the active form of folate that the body can readily use. L-Methylfolate, on the other hand, needs to be converted into L-5-Methyltetrahydrofolate before the body can use it. Therefore, taking L-5-Methyltetrahydrofolate may be more effective in supporting healthy methylation.

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