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What is the cost of treating mononucleosis infections?

Mononucleosis, often called "mono" or "the kissing disease," is a common viral infection that can significantly impact a person's daily life. While many are familiar with its symptoms, the costs associated with diagnosing and treating mono are less well-known. This comprehensive guide aims to shed light on the financial aspects of managing mononucleosis, from initial diagnosis to full recovery. We'll explore the various severity levels of the infection, break down the costs of different diagnostic methods, tests, medications, and potential procedures, and provide strategies to optimize your treatment plan for both cost and efficiency. Whether you're a patient seeking affordable care options or a healthcare provider looking to offer cost-effective solutions, this article will equip you with the knowledge to navigate the economic landscape of mononucleosis treatment. By the end, you'll have a clear understanding of what to expect financially when dealing with mono, empowering you to make informed decisions about your health and your wallet.
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Written by Andrew Le, MD.
Medically reviewed by
Last updated August 20, 2024

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Severity Levels of Mononucleosis Infection

Mononucleosis, often called "mono," can present with varying degrees of severity. Understanding these levels can help patients and healthcare providers determine the most appropriate course of action for diagnosis and treatment.

Mild Mononucleosis

Mild cases of mono are the most common and typically don't require extensive medical intervention.

  • Symptoms: Fatigue, sore throat, swollen lymph nodes
  • Risk factors: Recent exposure, age 15-24
  • Diagnosis: Self-diagnosis or virtual doctor consultation
  • Tests: Basic blood tests may be recommended but aren't always necessary
  • Treatments: Rest, hydration, over-the-counter pain relievers

Moderate Mononucleosis

Moderate cases may require medical attention to manage symptoms and prevent complications.

  • Symptoms: Fever, severe sore throat, significant fatigue
  • Risk factors: Compromised immune system, prolonged exposure
  • Diagnosis: In-person doctor visit recommended
  • Tests: Blood tests, including complete blood count and mono spot test
  • Treatments: Supportive treatment, increased rest, possibly prescription medications

Severe Mononucleosis

Severe cases are rare but can be serious, potentially requiring hospitalization.

  • Symptoms: Extreme fatigue, severe throat swelling, jaundice
  • Risk factors: Severely compromised immune system, complications like splenic rupture
  • Diagnosis: Emergency room visit often necessary
  • Tests: Comprehensive blood work, imaging studies (e.g., ultrasound for spleen enlargement)
  • Treatments: Possible hospitalization, IV fluids, steroids, close monitoring

Summary Table: Severity Levels

Severity LevelCharacteristicsDiagnosisLabs/ImagingTreatment
MildFatigue, sore throat, swollen lymph nodesSelf-diagnosis or virtual consultationBasic blood tests (optional)Rest, hydration, OTC pain relievers
ModerateFever, severe sore throat, significant fatigueIn-person doctor visitBlood tests (CBC, mono spot)Supportive care, increased rest, possible prescriptions
SevereExtreme fatigue, severe throat swelling, jaundiceEmergency room visitComprehensive blood work, imaging studiesPossible hospitalization, IV fluids, steroids, monitoring

Understanding these severity levels can help patients make informed decisions about seeking medical care and can guide healthcare providers in developing appropriate treatment plans. It's important to note that symptoms can progress, so what starts as a mild case may develop into a moderate or severe case, requiring adjustments in care and treatment.

Getting a Diagnosis

Getting an accurate diagnosis for mononucleosis is crucial for proper treatment. There are several options available, ranging from self-diagnosis to emergency room visits. Let's explore each option in detail, including costs and efficiency.

Self-diagnosis

Self-diagnosis is the most cost-effective option but may not be reliable for all cases of mononucleosis.

  • Cost: $0
  • Time: Immediate
  • Appropriate for: Mild symptoms in otherwise healthy individuals

While self-diagnosis doesn't incur any direct costs, it's important to note that misdiagnosis could lead to delayed treatment and potentially higher costs in the long run.

Virtual doctor consultation

Virtual consultations have become increasingly popular, offering convenience and cost-effectiveness.

  • Teladoc:
    • With insurance: As low as $0 per visit
    • Without insurance: $89 per visit
  • MDLive:
    • With insurance: $0 to $82 for urgent care
    • Without insurance: $82 for urgent care
  • OptimalMD: Free with OptimalMD membership ($47/month for the entire family)

Time: Same day or next day appointment, typically lasting 15-30 minutes

Virtual consultations are appropriate for mild to moderate symptoms and can be an excellent first step in diagnosing mononucleosis.

In-person doctor visit

For more thorough examinations, an in-person visit might be necessary.

  • Primary care physician:
    • With insurance: Copay typically ranges from $15 to $50
    • Without insurance: National average of $171, ranging from $68 for minor problems to $234 for complex issues
  • Urgent care centers:
    • With insurance: Copay typically ranges from $25 to $75
    • Without insurance: $100 to $150
  • OptimalMD: Free with OptimalMD membership

Time: 1-3 days for appointment, 15-30 minutes for visit

In-person visits are suitable for moderate symptoms or when physical examination is necessary.

Emergency room visit

For severe symptoms or complications, an emergency room visit may be necessary.

  • Emergency Room:
    • With insurance: Average of $1,082, but can vary widely based on insurance plan and services provided
    • Without insurance: Average of $1,220, ranging from $623 to $3,087

Time: Several hours wait, 1-2 hours for evaluation

Emergency room visits are appropriate for severe symptoms such as extreme fatigue, severe throat swelling, or jaundice.

Summary Table: Assessment Options

ModalityAppropriate SeverityPrice without InsurancePrice with InsuranceEfficiency
Self-diagnosisMild$0$0Immediate
Virtual consultation (Teladoc)Mild to Moderate$89As low as $0Same/Next day
Virtual consultation (MDLive)Mild to Moderate$82$0-$82Same/Next day
Primary care visitMild to Moderate$68-$234 (avg. $171)$15-$50 copay1-3 days wait
Urgent care visitMild to Severe$100-$150$25-$75 copaySame day

This table provides a quick overview of the diagnosis options, their appropriate use cases, costs, and efficiency. It's important to choose the right option based on the severity of symptoms and individual circumstances. While emergency care is the most expensive, it's crucial for severe cases. For mild to moderate symptoms, virtual consultations or urgent care centers often provide a good balance of cost and efficiency.

Imaging and Laboratory Tests

Imaging and laboratory tests are crucial for accurately diagnosing mononucleosis and assessing its severity. The costs and efficiency of these tests can vary significantly depending on the provider and payment method. Let's explore the options:

Complete Blood Count (CBC)

A CBC is often the first test ordered when mononucleosis is suspected. It can reveal an elevated white blood cell count, particularly lymphocytes.

  • LabCorp: $29.00 (cash price)
  • Quest Diagnostics: $29.00 (cash price), additional $79 for in-home collection if available
  • Hospital-based lab: Typically $100-$200 (before insurance)
  • Free with OptimalMD membership

Time: Results usually available in 1-2 business days.

Monospot Test

The Monospot test is a rapid blood test specifically designed to detect mononucleosis.

  • Urgent Care centers: $22-$197 (cash price, varies by location)
  • Primary care physician: Typically $50-$100 (before insurance)
  • Free with OptimalMD membership

Time: Results available in 15-30 minutes.

Epstein-Barr Virus (EBV) Antibody Test

This test is more specific for diagnosing mononucleosis caused by the Epstein-Barr virus.

  • LabCorp: Price not available (contact for pricing)
  • Quest Diagnostics: $59.15 (cash price)
  • Hospital-based lab: Typically $200-$400 (before insurance)
  • Heavily discounted with OptimalMD membership

Time: Results typically available in 2-3 business days.

Liver Function Tests

Liver function tests are often performed to check for any liver involvement in mononucleosis.

  • LabCorp: $36.00 - $113.99 (cash price)
  • Quest Diagnostics: Price not available (contact for pricing)
  • Hospital-based lab: Typically $100-$300 (before insurance)
  • Free with OptimalMD membership

Time: Results usually available in 1-2 business days.

Ultrasound (for severe cases)

In severe cases of mononucleosis, an ultrasound may be ordered to check for spleen enlargement.

  • Hospital Radiology Department: $445 - $839 (cash price, varies by location)
  • Outpatient imaging center: Typically $200-$400 (before insurance)
  • Heavily discounted with OptimalMD membership

Time: 30-60 minutes for the procedure, results often available the same day.

When considering these tests, it's important to note that prices can vary significantly based on your location, the specific provider, and your insurance coverage. Always check with your insurance provider to understand your coverage and potential out-of-pocket costs. For those without insurance, many facilities offer cash discounts or payment plans.

Here's a summary table of the imaging and laboratory tests for mononucleosis:

Summary Table: Diagnostics

TestSeverity LevelPrice without InsurancePrice with InsuranceEfficiency
Complete Blood Count (CBC)All$29 - $200$0 - $50 copay1-2 days
Monospot TestMild to Moderate$22 - $197$0 - $50 copay15-30 minutes
EBV Antibody TestAll$59 - $400$0 - $100 copay2-3 days
Liver Function TestsModerate to Severe$36 - $300$0 - $50 copay1-2 days
Abdominal UltrasoundSevere$200 - $839$50 - $250 copaySame day

Remember, with an OptimalMD membership ($47/month for the entire family), many of these tests are available for free or at heavily discounted rates, potentially leading to significant cost savings for families dealing with mononucleosis.

Prescription Medications

Prescription medications play a crucial role in managing more severe cases of mononucleosis infection. While most cases of mono are treated with supportive care, certain situations may require prescription interventions. Let's explore the options, their costs, and providers:

Corticosteroids (e.g., Prednisone)

Corticosteroids may be prescribed to reduce inflammation in severe cases, particularly when there's significant throat swelling.

  • Brand name (Rayos):
    • Cash price: $200 - $300 for a typical 5-day course
    • With insurance: $30 - $50 copay
    • With discount card: $150 - $250
  • Generic Prednisone:
    • Cash price: $10 - $40 for a typical 5-day course
    • With insurance: $5 - $15 copay
    • With discount card: $5 - $20
  • Free with OptimalMD membership

Providers:

  • CVS Pharmacy
  • Walgreens
  • Walmart Pharmacy
  • Rite Aid

Time: 5-10 day course

Antiviral Medications

While not typically prescribed for mononucleosis, in some cases, antiviral medications might be considered for severe or prolonged symptoms.

  • Brand name (Zovirax):
    • Cash price: $800 - $1000 for a typical course
    • With insurance: $50 - $100 copay
    • With discount card: $600 - $800
  • Generic Acyclovir:
    • Cash price: $20 - $70 for a typical course
    • With insurance: $10 - $30 copay
    • With discount card: $8 - $40
  • Free with OptimalMD membership

Providers:

  • CVS Pharmacy
  • Walgreens
  • Walmart Pharmacy
  • Rite Aid

Time: 7-10 day course

Pain Relievers (Prescription Strength)

For severe pain associated with mononucleosis, doctors may prescribe stronger pain relievers.

  • Brand name (Ultram):
    • Cash price: $150 - $200 for a typical 7-day course
    • With insurance: $30 - $50 copay
    • With discount card: $100 - $150
  • Generic Tramadol:
    • Cash price: $10 - $40 for a typical 7-day course
    • With insurance: $5 - $15 copay
    • With discount card: $8 - $30
  • Free with OptimalMD membership

Providers:

  • CVS Pharmacy
  • Walgreens
  • Walmart Pharmacy
  • Rite Aid

Time: As needed, typically prescribed for 3-7 days

It's important to note that while these medications can be effective in managing symptoms, they should only be taken under the guidance of a healthcare professional. The decision to prescribe any of these medications will depend on the severity of the mononucleosis infection and the individual patient's needs.

Summary Table: Prescription Medications

MedicationSeverity LevelPrice Without InsurancePrice With InsuranceEfficiency
Prednisone (Generic)Moderate to Severe$10 - $40$5 - $15 copay5-10 day course
Acyclovir (Generic)Severe$20 - $70$10 - $30 copay7-10 day course
Tramadol (Generic)Moderate to Severe$10 - $40$5 - $15 copay3-7 day course
OptimalMD MembershipAll Levels$47/month for familyN/AVaries

Note: All medications listed are free or heavily discounted with OptimalMD membership. Brand name medications are typically significantly more expensive than their generic counterparts.

Over-the-Counter Treatments

Over-the-counter (OTC) treatments play a crucial role in managing the symptoms of mononucleosis infection. These treatments are generally affordable and easily accessible, making them a cost-effective option for patients with mild to moderate symptoms. Let's explore the various OTC options, their costs, and where to find them.

Pain relievers (e.g., Acetaminophen, Ibuprofen)

Pain relievers are essential for managing fever and discomfort associated with mononucleosis. Let's look at the costs for two common options:

1. Acetaminophen (e.g., Tylenol)

  • Brand name (Tylenol Extra Strength):
    • National average: $15-$20 for 225 count
    • Walmart: $19.97 for 225 count
    • Amazon: $4.47 (count not specified)
    • CVS Pharmacy: $4.29 to $23.99 (count varies)
  • Generic Acetaminophen:
    • Average retail price: $8.86
    • With GoodRx coupon: $3.15 (64% off retail)

2. Ibuprofen (e.g., Advil)

  • Brand name (Advil):
    • National average: $10-$15 for 100 count
    • Walmart: $7.64 to $12.78 (count varies)
    • Walgreens: $5.99 to $21.99 (count varies)
    • CVS Pharmacy: $11.99 for 100 count
  • Generic Ibuprofen:
    • Typically 20-40% cheaper than brand name
    • Estimated range: $6-$10 for 100 count

Throat lozenges

Throat lozenges can provide temporary relief for sore throat symptoms associated with mononucleosis.

  • Brand name (Cepacol):
    • National average: $6-$8 for 16 lozenges
    • Walgreens: $5.99 for 16 lozenges
    • Amazon: $5.99 for 48 lozenges (3-pack)
    • CVS: $7.99 for 16 lozenges, or 2 for $12.00
  • Generic throat lozenges:
    • Typically 10-30% cheaper than brand name
    • Estimated range: $4-$6 for 16 lozenges

Oral rinses

Oral rinses can help soothe a sore throat and maintain oral hygiene during mononucleosis infection.

  • Chlorhexidine Gluconate (prescription strength):
    • National average: $10-$16 for 16 oz (473 ml)
    • Discounted price: $6.00-$7.38 for 16 oz
    • Generic version: As low as $2.01 for 16 oz
  • Over-the-counter oral rinses (e.g., Listerine, store brands):
    • Brand name: $5-$8 for 16 oz
    • Generic/store brand: $3-$5 for 16 oz

Summary Table: OTCs

ModalitySeverity LevelPrice without InsurancePrice with Insurance/DiscountEfficiency
Acetaminophen (Tylenol)Mild to Moderate$15-$20 (brand)$8-$9 (generic)$3-$5 (with coupon)High
Ibuprofen (Advil)Mild to Moderate$10-$15 (brand)$6-$10 (generic)N/A (OTC)High
Throat LozengesMild to Moderate$6-$8 (brand)$4-$6 (generic)N/A (OTC)Moderate
Oral RinsesMild to Moderate$5-$8 (OTC)$10-$16 (prescription)$2-$7 (prescription)Moderate

This table provides a quick overview of the OTC treatments available for mononucleosis, their appropriate use cases, pricing with and without insurance or discounts, and their general efficiency in managing symptoms. Remember that while these treatments can help alleviate symptoms, they do not cure the underlying viral infection. Always consult with a healthcare provider for proper diagnosis and treatment recommendations.

Procedures

In severe cases of mononucleosis, certain medical procedures may be necessary to manage complications or provide supportive care. The two main procedures associated with mononucleosis treatment are IV fluid administration and, in rare cases, tonsillectomy.

IV Fluid Administration

IV fluid administration is often necessary for patients with severe mononucleosis who are experiencing dehydration or having difficulty swallowing due to severe throat pain.

  • National Average: $200 - $1,000 per treatment
  • With Insurance: Costs can vary significantly based on your plan, but typically, you'll be responsible for a copay or coinsurance. This could range from $20 to $200 per treatment.
  • Without Insurance: Expect to pay the full amount, which could be $200 - $1,000 or more per treatment.

Examples of providers and their prices:

  1. IV League Hydration (New York, NY)
    • Basic IV Hydration: $159
    • Premium IV Hydration: $199
  2. Hydration Room (Los Angeles, CA)
    • Basic Hydration: $175
    • Deluxe Hydration: $225
  3. IVitamin (Chicago, IL)
    • Standard Hydration: $149
    • Premium Hydration: $199

Efficiency: IV fluid administration typically takes 1-4 hours per session, with immediate effects on hydration levels.

Tonsillectomy

In rare cases where mononucleosis leads to severe, recurring tonsillitis or airway obstruction, a tonsillectomy may be recommended.

  • National Average: $3,425 - $8,984
  • With Insurance: Depending on your plan, you may be responsible for a copay (typically $250 - $500) or coinsurance (20% - 30% of the total cost).
  • Without Insurance: You may be required to pay the full amount, which could range from $3,425 to $8,984 or more.

Examples of providers and their prices:

  1. Memorial Hermann Health System (Houston, TX)
    • Cash Price: $5,300
  2. UCLA Health (Los Angeles, CA)
    • Cash Price: $6,800
  3. Mayo Clinic (Rochester, MN)
    • Cash Price: $7,500

Efficiency: A tonsillectomy is typically an outpatient procedure lasting about 30-45 minutes. However, full recovery can take 10-14 days.

Summary Table: Procedures

ProcedureSeverity LevelPrice Without InsurancePrice With InsuranceEfficiency
IV Fluid AdministrationSevere$200 - $1,000 per treatment$20 - $200 copay1-4 hours per session, immediate effects
TonsillectomySevere (rare cases)$3,425 - $8,984$250 - $500 copay or 20-30% coinsurance30-45 minute procedure, 10-14 days recovery

It's important to note that these prices are estimates and can vary based on location, specific provider, and individual circumstances. Always consult with your healthcare provider and insurance company for the most accurate cost information for your specific situation.

Optimizing for Cost

When seeking the most cost-effective treatment for mononucleosis infection, consider the following strategies for each severity level:

Mild Mononucleosis

  1. Self-diagnosis using reputable online resources
  2. Virtual doctor consultation if symptoms persist
  3. Over-the-counter generic pain relievers and throat lozenges
  4. Rest and hydration at home

Moderate Mononucleosis

  1. Virtual doctor consultation for initial assessment
  2. In-person visit at a primary care physician or urgent care center (avoid ER)
  3. Basic blood tests (CBC and Monospot) at an independent lab facility
  4. Generic prescription medications if necessary
  5. Continue with OTC treatments and rest

Severe Mononucleosis

  1. Urgent care or ER visit (based on symptom severity)
  2. Comprehensive blood work at the care facility
  3. Generic prescription medications
  4. Outpatient IV fluid administration if possible
  5. Follow-up with primary care physician for ongoing management

Cost-Saving Tips:

  • Compare prices for lab tests and imaging at different facilities
  • Ask for generic medications when possible
  • Utilize telemedicine services for follow-up consultations
  • Check with your insurance provider about in-network options and coverage
  • Consider urgent care centers instead of emergency rooms when appropriate
  • Take advantage of pharmacy discount programs for medications

By following these cost-optimized approaches, patients can receive appropriate care for their mononucleosis infection while minimizing out-of-pocket expenses. Remember that early intervention and proper care can prevent complications and potentially reduce overall treatment costs in the long run.

Optimizing for Efficiency

When time is of the essence, optimizing the treatment process for mononucleosis can help patients recover faster and minimize disruption to their daily lives. Here are efficient strategies for each severity level:

Mild Mononucleosis

  1. Virtual doctor consultation for quick diagnosis
    • Time saved: Eliminates travel and waiting room time
    • Cost: Typically lower than in-person visits
  2. At-home rapid mono test kit
    • Time saved: Immediate results without lab wait times
    • Cost: May be more expensive than lab tests
  3. Over-the-counter treatments delivered same-day
    • Time saved: Avoid trips to the pharmacy
    • Cost: Potential delivery fees

Moderate Mononucleosis

  1. Urgent care center visit for same-day diagnosis and testing
    • Time saved: Faster than waiting for primary care appointment
    • Cost: May be higher than regular office visit
  2. Comprehensive blood panel including mono test and liver function
    • Time saved: All tests done at once
    • Cost: May be more expensive initially but saves repeat visits
  3. Electronic prescription for corticosteroids if needed
    • Time saved: Medication ready for pickup upon leaving clinic
    • Cost: No additional cost

Severe Mononucleosis

  1. Emergency room visit for immediate care
    • Time saved: Immediate attention and comprehensive care
    • Cost: Highest cost option but necessary for severe cases
  2. On-site ultrasound and lab work
    • Time saved: All diagnostics completed in one visit
    • Cost: Bundled with ER visit
  3. Admission for IV fluids and monitoring if necessary
    • Time saved: Continuous care without need for return visits
    • Cost: Significant but may prevent complications

General Efficiency Tips

  1. Utilize patient portals for quick communication with healthcare providers
  2. Opt for electronic health records to streamline information sharing
  3. Choose pharmacies with drive-through or delivery options
  4. Use telemedicine for follow-up appointments when possible

By prioritizing efficiency in the diagnosis and treatment of mononucleosis, patients can minimize the impact on their daily lives and potentially speed up recovery time. However, it's important to note that the most efficient options may not always be the most cost-effective, and a balance should be struck based on individual circumstances and severity of the condition.

Balancing Cost and Efficiency

When treating mononucleosis infection, it's crucial to find a balance between cost-effectiveness and efficiency. Here are recommended approaches for each severity level:

Mild Mononucleosis

  • Start with self-diagnosis and over-the-counter treatments
  • If symptoms persist, opt for a virtual doctor consultation
  • Use generic pain relievers and throat lozenges
  • Focus on rest and hydration to speed recovery

Moderate Mononucleosis

  • Begin with a virtual doctor consultation for initial assessment
  • If recommended, follow up with an in-person visit and basic blood tests
  • Choose generic medications when possible
  • Consider at-home monitoring with regular virtual check-ins to avoid unnecessary office visits

Severe Mononucleosis

  • Seek immediate medical attention through an emergency room visit
  • Undergo necessary comprehensive testing (blood work and imaging)
  • Accept hospital admission if recommended to prevent complications
  • Follow up with a primary care physician post-discharge to monitor recovery and adjust treatment as needed

For all severity levels, consider these cost-efficient and time-saving strategies:

  • Utilize telemedicine when appropriate to reduce travel time and costs
  • Request generic medications and over-the-counter alternatives when possible
  • Follow treatment plans diligently to prevent complications and additional medical visits
  • Maintain open communication with healthcare providers to adjust treatment plans as needed, potentially reducing unnecessary tests or medications

By carefully considering both cost and efficiency, patients can receive appropriate care for mononucleosis infection while minimizing financial burden and time spent on treatment. Always consult with a healthcare professional to determine the best approach for individual circumstances.

Conclusion

Mononucleosis infection, while often self-limiting, can vary significantly in severity and treatment needs. Understanding the costs associated with diagnosis and treatment is crucial for patients seeking affordable and effective care. Here are the key takeaways:

  1. Severity matters: The cost of treating mononucleosis can range from minimal for mild cases to substantial for severe cases requiring hospitalization.
  2. Early diagnosis is cost-effective: Identifying the infection early through appropriate testing can prevent complications and reduce overall treatment costs.
  3. Most cases are manageable at home: For mild to moderate cases, rest, hydration, and over-the-counter medications are often sufficient and cost-effective.
  4. Insurance coverage is important: The out-of-pocket costs can vary greatly depending on insurance status and coverage.
  5. Generic medications can save money: When prescription medications are necessary, opting for generic versions can significantly reduce costs.
  6. Virtual consultations offer a balance: For many cases, telemedicine provides a cost-effective and efficient way to get diagnosed and receive treatment recommendations.
  7. Severe cases require immediate attention: While more costly, prompt treatment for severe cases can prevent serious complications and potential long-term health issues.
  8. Prevention is key: Practicing good hygiene and avoiding close contact with infected individuals can help prevent mononucleosis, eliminating treatment costs altogether.

By considering these factors and working closely with healthcare providers, patients can navigate the treatment of mononucleosis infection in a way that balances cost, efficiency, and effectiveness. Remember, while managing costs is important, prioritizing proper medical care is crucial for a full and speedy recovery.

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Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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