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Balancing Brain Health with Probiotics: A Breakthrough Study in Older Adults

Written by Andrew Le, MD

UpdatedJuly 22, 2024

Healthy older adults may enhance their cognitive functions through the intake of a specific multi-species probiotic, as suggested by a remarkable study (Source).

It's common to experience cognitive decline with age, but a groundbreaking double-blind randomized placebo-controlled crossover trial indicates that a probiotic mix containing Lactobacillus rhamnosus and Bifidobacterium lactis might help mitigate this.

Spanning between July 2020 and April 2022, the trial involved 33 participants consuming either a placebo or the probiotic daily for ten weeks, followed by a four-week washout before the second condition started. Researchers looked at several measures including cognitive function, memory, and emotional state.

Surprisingly, after the intervention, significant improvements were observed across several cognitive and emotional functions. The probiotic group saw increased cognitive function and memory scores plus a notable decrease in depressive symptoms. Planning and problem-solving skills, selective attention, cognitive flexibility, and inhibitory ability also saw a boost.

What makes these results truly significant is the limited existing research that supports the notion of probiotics being an effective therapy for cognitive decline. However, the study emphasizes the importance of more scientific evidence to solidify probiotics' role as a viable intervention strategy.

For further details and a link to the trial, visit ClinicalTrials.gov under the identifier NCT04828421. The study's correspondence is handled by Lola Rueda-Ruzafa (lrr606@ual.es) and involves a team of researchers hailing from the University of Almeria and other research centers in Spain.

This study not only shines a light on the gut-brain axis' potential but opens new avenues for maintaining cognitive functions in our later years through dietary strategies.

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References

Ruiz-Gonzalez, C., Cardona, D., Rueda-Ruzafa, L., Rodriguez-Arrastia, M., Ropero-Padilla, C., & Roman, P. (2024). Cognitive and Emotional Effect of a Multi‑species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double-Blind Randomized Placebo-Controlled Crossover Trial. Probiotics and Antimicrobial Proteins. https://doi.org/10.1007/s12602-024-10315-2