Citrus Bergamot for Cholesterol Management: Understanding Its Benefits
UpdatedSeptember 5, 2024
Managing cholesterol levels effectively is crucial for maintaining cardiovascular health and preventing heart disease. Globally, approximately 39% of adults have raised total cholesterol, contributing to substantial health issues. In 2019, high non-HDL cholesterol accounted for 98.6 million disability-adjusted life years (DALYs) and an estimated 4.4 million deaths
Despite the importance of cholesterol control, many people face challenges with traditional cholesterol-lowering medications like statins, which can cause side effects such as muscle pain, digestive problems, and an increased risk of diabetes. These side effects create significant barriers for those seeking safe and effective ways to manage their cholesterol.
Natural alternatives have emerged as promising solutions. Citrus Bergamot has been extensively studied for its unique ability to positively influence lipid profiles. Rich in polyphenols, Citrus Bergamot can reduce bad cholesterol (LDL) and triglycerides while boosting good cholesterol (HDL).
Recognizing the potential of this natural remedy, we have meticulously researched and compiled a list of the top Citrus Bergamot supplements. Each selected product supports cholesterol management and enhances overall cardiovascular health without the harsh side effects of conventional medications.
Citrus Bergamot Supplement for Cholesterol
Citrus bergamot, a citrus fruit native to southern Italy, has garnered attention for its potential to improve cardiovascular health, particularly in reducing cholesterol levels. Here is some clinical evidence supporting the efficacy of Citrus bergamot supplements in managing cholesterol, drawing from multiple studies and clinical trials.
Clinical Applications and Evidence
One study highlights that Citrus bergamot contains a variety of phytochemicals, such as brutieridin and melitidin, which are linked to cholesterol reduction. In multiple clinical trials, these compounds have been shown to lower total cholesterol and low-density lipoprotein cholesterol (LDL-C), suggesting bergamot's potential as an alternative treatment for hypercholesterolemia.
A randomized, double-blind, placebo-controlled study involving 60 patients with mixed hyperlipidemia found significant reductions in total cholesterol, LDL-C, and triglycerides after 30 days of bergamot polyphenol fraction (BPF) supplementation. HDL cholesterol levels also increased, indicating an overall improvement in lipid profiles.
Similarly, one study observed notable reductions in total cholesterol, LDL-C, and triglycerides and an increase in HDL cholesterol in a six-month open-label trial with 80 subjects. This study further supported bergamot's role in lipid management and its potential as a complementary treatment alongside statins.
Mechanism of Action
The cholesterol-lowering effects of bergamot are attributed to several mechanisms. One study investigated these mechanisms in HepG2 and Caco-2 cells, finding that bergamot extract (BFE) and its components, particularly neohesperidin, decreased HMG-CoA reductase levels and increased AMP-kinase phosphorylation.
These actions suggest that bergamot lowers cholesterol through pathways distinct from those targeted by statins, potentially offering an alternative for patients intolerant to statins.
One body of research proposed that bergamot polyphenols might inhibit pancreatic cholesterol ester hydrolase (pCEH), further improving lipid profiles in hyperlipidemic patients. This inhibition disrupts cholesterol synthesis, providing a multi-faceted approach to managing cholesterol levels.
Comparative Studies with Statins
One previous study compared the effects of BPF with rosuvastatin, a common statin. The study found that both treatments significantly reduced total cholesterol and LDL-C. Combining BPF with rosuvastatin enhanced the lipid-lowering effects without additional side effects, suggesting that bergamot could be used synergistically with statins.
Benefits and Limitations of Bergamot Supplementation
Bergamot supplements offer several advantages, particularly for patients who experience adverse effects from statins. The natural polyphenols in bergamot provide antioxidant and anti-inflammatory benefits, contributing to overall cardiovascular health.
Additionally, bergamot has been well-tolerated in studies ranging from 30 days to six months, with minimal side effects reported.
However, the studies reviewed also indicate some limitations. The designs of the clinical trials varied, with some using open-label formats that might introduce bias. Additionally, the preparation, extraction, and standardization of bergamot supplements differed across studies, leading to variability in the results.
Best Citrus Bergamot Supplement for Cholesterol
We have researched the top Citrus Bergamot supplements and selected them based on their effectiveness, safety, and consumer satisfaction. These supplements are noted for their potential to improve cardiovascular health by managing cholesterol levels.
Eleva Nutrition's Citrus Bergamot Extract 25:1 and Citrus Bergamot Complex + Bioflavonoids Bundle provides a comprehensive approach to supporting cardiovascular health and overall well-being. Made from a potent 25:1 citrus bergamot extract, sourced primarily from Italy and France, this supplement is rich in polyphenols, offering 20% more than other leading brands.
The bundle includes both Citrus Bergamot Extract 1000mg capsules and Citrus Bergamot Complex 1000mg capsules, each enhanced with a citrus bioflavonoid complex and black pepper extract for improved nutrient absorption.
Pros
- High polyphenol content (50% polyphenols) supports antioxidant activity and cardiovascular health.
- Natural black pepper extract aids in the absorption of key nutrients, enhancing effectiveness.
- Clean label with no fillers, GMOs, gluten, or other additives, suitable for vegans.
- Provides a full-spectrum effect through both citrus bergamot powder and extract.
- Family-owned small business emphasizing quality and purity in their products.
Cons
- Requires consistent daily use to maintain benefits, which may be a commitment for some users.
- Some individuals may prefer different forms of supplementation (e.g., liquid or powder).
- Individual results may vary, particularly regarding how quickly benefits are noticed.
NutriFlair Organic Citrus Bergamot 1400mg offers a potent blend of bergamot essential oil and citrus bioflavonoids designed to support heart health naturally. Each capsule contains 1400mg of citrus bergamot extract, derived from 25:1 concentrate, ensuring maximum effectiveness.
This supplement is formulated without fillers, preservatives, soy, or gluten, aligning with NutriFlair’s commitment to purity and quality. It is manufactured in the USA in a facility adhering to strict cGMP standards and undergoes third-party testing for purity and potency.
Pros
- Natural ingredients sourced from 100% pure citrus bergamot, free from additives and GMOs.
- High potency with 1400mg per serving, providing robust cardiovascular support.
- Contains citrus bioflavonoids and bergamot essential oil, potent antioxidants that aid in maintaining healthy lipids and supporting the body's natural defenses.
- Fast-absorbing formula for quick effectiveness, suitable for daily use.
- Backed by NutriFlair's satisfaction guarantee, ensuring customer confidence and product quality.
Cons
- Some users may find the large capsule size difficult to swallow.
- May not be suitable for individuals with citrus allergies.
- Higher potency may require adjustment for those sensitive to strong herbal extracts.
- Occasional availability issues due to popularity may occur.
NAOMI BergAmore 1000 is a meticulously crafted dietary supplement designed by award-winning cardiologist Naomi Whittel to support cardiovascular health. Each capsule contains a potent blend of Italian citrus bergamot extract enriched with 7 key polyphenols and vitamin C.
This formulation is scientifically proven to promote healthy cholesterol levels, support cardiovascular function, and enhance overall metabolic wellness. It stands out for its clinically validated effectiveness, fast-acting results, and commitment to quality ingredients sourced from Italy.
Pros
- Clinically shown to support healthy cholesterol levels and cardiovascular function.
- Formulated with a high potency of citrus bergamot extract and 7 key polyphenols for enhanced efficacy.
- Supported by gold-standard clinical trials demonstrating its effectiveness within just 30 days.
- Manufactured in the USA in an FDA-regulated facility, ensuring quality and purity.
- Non-GMO, gluten-free, and vegan, making it suitable for various dietary preferences.
- Developed by Naomi Whittel, a renowned wellness advocate and author, known for her innovative approach to health.
Cons
- May require consistent daily use to maintain benefits.
- Individual results may vary in terms of cholesterol level improvements.
- Capsule form may not be preferred by those who have difficulty swallowing pills.
BergaMet Bergamot Citrus Supplement offers a potent blend of Italian citrus bergamot extract enriched with 80% polyphenols per serving. Manufactured in the USA by BergaMet North America, this dietary supplement is designed to support cardiovascular health and overall well-being. Each bottle contains 120 capsules, providing a convenient supply for daily use.
Pros
- Contains 1200mg of citrus bergamot extract per serving with 80% polyphenols, ensuring a high concentration of beneficial compounds.
- Supported by multiple clinical studies demonstrating its effectiveness in promoting healthy cholesterol levels and cardiovascular function.
- Vegan-friendly and free from gluten, dairy, soy, and artificial additives, catering to various dietary preferences and restrictions.
- Manufactured in a certified facility in the USA, ensuring quality control and adherence to rigorous standards.
- Favorable customer reviews highlight its efficacy in supporting cholesterol management and overall heart health.
Cons
- Some users may experience mild side effects such as gastrointestinal discomfort or headaches, although these are infrequent.
- Requires daily consumption to maintain benefits, which may be a consideration for those preferring less frequent dosing.
Secret Element Citrus Bergamot Extract 1000mg offers a potent solution for maintaining cardiovascular health and supporting immune function. Each capsule contains pure bergamot extract, rich in polyphenols and antioxidants, aimed at promoting healthy cholesterol levels and overall heart wellness.
Manufactured in the USA under strict quality standards, this supplement is designed to enhance cellular energy production and combat oxidative stress, contributing to a balanced and vibrant lifestyle.
Pros
- Supports cardiovascular health with a high concentration of bergamot polyphenols.
- Enhances immune function and provides antioxidant protection against free radicals.
- Formulated for maximum bioavailability, ensuring effective absorption and utilization.
- Vegan, gluten-free, and made from natural ingredients, suitable for various dietary preferences.
- Produced in a cGMP-certified facility in the USA, ensuring purity and potency.
Cons
- Some users may find the capsules large and difficult to swallow.
- Requires daily intake of two capsules, which may be inconvenient for some individuals.
- Results in terms of cholesterol management can vary among users.
- May not be suitable for those allergic to citrus fruits or with specific dietary restrictions beyond vegan and gluten-free diets.
Organic Cadane Citrus Bergamot Extract Capsules offer a potent blend designed to support cardiovascular health and overall wellbeing. Each capsule contains a high concentration of ingredients like Citrus Bergamot, Berberine, Olive, Guggul, Garlic, Pine Bark, and Black Pepper.
This combination aims to provide users with comprehensive health benefits, including cholesterol management and immune system support. Manufactured in GMP and ISO-certified facilities, the product ensures quality and potency.
Pros
- Contains a powerful blend of Citrus Bergamot, Berberine, Olive, Guggul, Garlic, Pine Bark, and Black Pepper for enhanced health benefits.
- Each capsule delivers a high potency equivalent to 10300mg per serving, ensuring effective dosage with just one capsule daily.
- Supports cardiovascular health and helps in maintaining healthy cholesterol levels.
- Manufactured in GMP and ISO-certified facilities, ensuring high quality and purity.
- Suitable for vegetarians, with capsules made from vegetarian sources.
- Comes with a 4 months supply, offering good value for money with economical pricing per serving.
Cons
- Taste may not be appealing to all users due to the natural flavors of its herbal ingredients.
- While effective for many, results may vary depending on individual health conditions.
- Some users may find swallowing capsules daily inconvenient compared to liquid forms.
- Contains garlic, which may cause minor breath odor in some individuals.
Final Words
Among the top Citrus Bergamot supplements reviewed, NutriFlair Organic Citrus Bergamot stands out due to its exceptional potency and commitment to purity. This supplement offers 1400mg of bergamot per serving and a robust cardiovascular support system.
Its formulation is free from additives and preservatives, aligning with those who prioritize natural, high-quality ingredients. Furthermore, including essential oils and bioflavonoids enhances its antioxidant capabilities, making it a powerful tool for maintaining healthy cholesterol levels.
If you're looking for a natural way to support your heart health and manage cholesterol effectively, consider trying NutriFlair Organic Citrus Bergamot. Explore the benefits of this top-tier supplement and take a proactive step towards a healthier cardiovascular system.
FAQs on Citrus Bergamot Supplement for Cholesterol
Are there any people who should avoid taking Citrus Bergamot?
People who are pregnant, nursing, or have certain allergies should avoid Citrus Bergamot.
What are the potential side effects of Citrus Bergamot supplements?
Potential side effects include muscle cramps, heartburn, dizziness, and headaches.
References
- Nauman, M. C., & Johnson, J. J. (2019). Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers. Integrative Food, Nutrition, and Metabolism, 6(2), Article e1000249. https://doi.org/10.15761/IFNM.1000249
- Mollace, V., Scicchitano, M., Paone, S., Casale, F., Calandruccio, C., Gliozzi, M., Musolino, V., Carresi, C., Maiuolo, J., Nucera, S., Riva, A., Allegrini, P., Ronchi, M., Petrangolini, G., & Bombardelli, E. (2019). Hypoglycemic and hypolipemic effects of a new lecithin formulation of bergamot polyphenolic fraction: A double-blind, randomized, placebo-controlled study. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(2), 136-143. https://doi.org/10.2174/1871530319666181203151513
- Toth, P. P., Patti, A. M., Nikolic, D., Giglio, R. V., Castellino, G., Biancucci, T., Geraci, F., David, S., Montalto, G., Rizvi, A., & Rizzo, M. (2016). Bergamot reduces plasma lipids, atherogenic small dense LDL, and subclinical atherosclerosis in subjects with moderate hypercholesterolemia: A 6-month prospective study. Frontiers in Pharmacology, 6, Article 299. https://doi.org/10.3389/fphar.2015.00299
- Huang, Y., Tocmo, R., Nauman, M. C., Haughan, M. A., & Johnson, J. J. (2021). Defining the cholesterol lowering mechanism of bergamot (Citrus bergamia) extract in HepG2 and Caco-2 cells. Nutrients, 13(9), Article 3156. https://doi.org/10.3390/nu13093156
- Musolino, V., Gliozzi, M., Carresi, C., Maiuolo, J., Mollace, R., Bosco, F., Scarano, F., Scicchitano, M., Maretta, A., Palma, E., Iannone, M., Morittu, V. M., Gratteri, S., Muscoli, C., Fini, M., & Mollace, V. (2017). Lipid-lowering effect of bergamot polyphenolic fraction: Role of pancreatic cholesterol ester hydrolase. Journal of Biological Regulators and Homeostatic Agents, 31(4), 1087-1093. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29254319
- Gliozzi, M., Walker, R., Muscoli, S., Vitale, C., Gratteri, S., Carresi, C., Musolino, V., Russo, V., Janda, E., Ragusa, S., Aloe, A., Palma, E., Muscoli, C., Romeo, F., & Mollace, V. (2013). Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. International Journal of Cardiology, 170(2), 140-145. https://doi.org/10.1016/j.ijcard.2013.08.125