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Red Clover Supplements: Menopause Support and Symptom Management

Written by Andrew Le, MD

UpdatedSeptember 5, 2024

Most women experience menopause between the ages of 45 and 55 as a natural part of biological aging. This transition often brings challenging symptoms like hot flashes, night sweats, and mood swings due to a natural decline in estrogen levels. Many women seek relief from these discomforts but are cautious about hormone replacement therapies and their potential side effects.

The struggle with menopausal symptoms can significantly disrupt daily life and overall well-being. The inconsistency in relief from conventional treatments only adds to the frustration, prompting many to search for alternative, natural solutions.

Fortunately, red clover supplements, rich in isoflavones, offer a promising natural remedy for menopausal relief. These products are designed to support hormonal balance and alleviate symptoms. By incorporating these high-quality, safe supplements into your routine, you may find a gentle and effective way to manage menopausal discomfort.

Red Clover Isoflavones: Benefits and Safety for Menopausal Relief

Red clover (Trifolium pratense) contains isoflavones such as genistein and daidzein, phytoestrogens—plant-derived compounds that structurally resemble human estrogen. This similarity allows them to bind to estrogen receptors, potentially exerting estrogen-like effects in the body.

During menopause, the decline in natural estrogen levels can lead to symptoms like hot flashes, night sweats, and mood disturbances. Phytoestrogens from red clover may help mitigate these symptoms by providing a mild estrogenic effect.

While the specific mechanisms are not fully understood, it is believed that red clover isoflavones may balance estrogen levels, providing relief from menopausal symptoms. However, the effectiveness of these supplements can vary significantly depending on individual factors such as the severity of symptoms and the specific formulation of the red clover extract used.

Efficacy in Reducing Vasomotor Symptoms

The most common and distressing symptoms during menopause are vasomotor symptoms, including hot flashes and night sweats. Various studies have explored the efficacy of red clover in alleviating these symptoms.

For instance, one meta-analysis found that red clover supplementation significantly reduced the frequency of hot flashes compared to placebo, particularly in women experiencing severe symptoms.

Another study reinforced these findings, highlighting that women taking red clover experienced fewer hot flashes per day. Despite these promising results, the degree of improvement varied among studies, and not all found significant differences compared to placebo. This indicates that while red clover may benefit some women, its effects are not universally experienced.

Impact on Psychological and Quality of Life Parameters

Menopausal symptoms often extend beyond physical discomfort, affecting psychological well-being and overall quality of life. Red clover has been investigated for its potential to improve these aspects.

One study examined the impact of red clover on quality of life measures, including psychological and physical domains. The results indicated that while the red clover and placebo groups reported improvements, the difference was insignificant, suggesting a potential placebo effect.

However, some studies have reported improvements in mood and reductions in anxiety and stress levels among red clover users, although these findings are inconsistent. The varying results may be due to differences in study designs, dosages, and the populations studied, highlighting the need for further research to clarify these effects.

Safety Profile and Drug Interactions

Safety is a critical consideration for any supplement, especially for those used during menopause. One study assessed the safety of red clover by examining its interactions with common medications metabolized by cytochrome P450 enzymes.

The study concluded that red clover, at 120 mg of isoflavones per day, did not produce clinically significant interactions, suggesting a good safety profile. Additionally, the use of red clover in clinical studies for up to three years has not been associated with severe adverse effects.

However, it is recommended that women consult with healthcare providers before starting red clover supplements, especially if they are pregnant, breastfeeding, or taking other medications, as the long-term safety and interactions with other drugs are not fully established.

Best Red Clover Supplements for Menopause Support

We have researched the top red clover supplements and selected them based on their quality, safety, efficacy, and user reviews. These supplements are renowned for their potential benefits in managing menopausal symptoms such as hot flashes, night sweats, and mood swings by leveraging the isoflavones naturally found in red clover.


Nature’s Way Red Clover Blossom Herb

Nature’s Way Red Clover Blossom Herb

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Nature’s Way Red Clover Blossom Herb offers a natural approach to supporting women's health with its 800 mg per serving capsules. This supplement, derived from red clover blossoms, is traditionally used to promote hormonal balance and overall well-being, particularly during menopause. The product is formulated with high-quality botanicals sourced from optimal growing locations, ensuring the best possible efficacy.

As a trusted brand, Nature’s Way ensures this supplement is non-GMO, gluten-free, and free from artificial additives, making it a safe choice for various dietary needs. The eco-conscious packaging, made from 97% post-consumer recycled materials, reflects the brand's commitment to sustainability.

Pros

  • This product is noted for its high-quality ingredients, sourced from regions where they grow best, ensuring potency and efficacy.
  • It supports women's health, particularly during menopause, by promoting hormonal balance and alleviating symptoms like hot flashes and mood swings.
  • The capsules are vegan and free from common allergens like gluten, soy, and dairy, making them accessible to individuals with dietary restrictions.
  • Nature’s Way has a strong reputation for quality and safety, which is further validated by the product's being Non-GMO Project Verified.
  • The environmentally friendly packaging made from recycled materials underscores the brand’s commitment to sustainability.

Cons

  • Some users report mild side effects such as dizziness or water retention, which may not suit everyone.
  • The natural estrogen-like effects of red clover may not be suitable for people with specific health conditions or those who avoid phytoestrogens.
  • Although generally well-tolerated, the taste and size of the capsules might only be appealing to some.

NOW Supplements offers Red Clover

NOW Supplements offers Red Clover

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NOW Supplements offers Red Clover, an herbal supplement containing 375 mg per serving of the red clover plant (Trifolium pratense). Known for its traditional use in both Eastern and Western medicine, red clover is reputed for its potential to support women's health, particularly during menopause.

The supplement comes in a bottle containing 100 vegan capsules, which are easy to integrate into daily health routines. Packaged by NOW Sports - Nutrition and Wellness, a family-owned company since 1968, this product emphasizes quality assurance through NPA A-rated GMP certification, ensuring thorough examination of the manufacturing process, including laboratory testing for stability and potency.

Pros

  • Red Clover is a natural herb traditionally used to support women's health, making it a popular choice for those seeking natural remedies for menopausal symptoms.
  • The product is vegan, catering to various dietary preferences and restrictions, including those avoiding animal products.
  • NOW Supplements is a reputable brand with a long history of producing high-quality supplements, as evidenced by its GMP certification.
  • The capsules are free from common allergens such as gluten, soy, and dairy, making them suitable for individuals with various food sensitivities.
  • The product is affordably priced, offering good value for the quality and quantity provided.

Cons

  • Some users may experience mild side effects, such as gastrointestinal discomfort when taking herbal supplements.
  • The capsules contain a relatively low dosage of red clover, which may need to be increased for those seeking a higher potency or stronger effects.
  • The product carries a California Proposition 65 warning for potential exposure to chemicals known to cause reproductive harm, which may be a concern for some consumers.

Piping Rock Red Clover Capsules

Piping Rock Red Clover Capsules

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Piping Rock Red Clover Capsules provide a potent herbal supplement featuring a concentrated extract of red clover blossoms. Each capsule delivers the equivalent of 1200 mg of red clover, known for its naturally occurring isoflavones. This product is designed to support overall well-being, particularly in women, by leveraging the traditional benefits of red clover, which has been used in herbal medicine for centuries.

The capsules are manufactured by Piping Rock, a brand committed to quality and purity, with their supplements being non-GMO, gluten-free, and rigorously tested in the lab for potency and safety.

Pros

  • Piping Rock Red Clover Capsules offer a high potency formula, providing a significant dose of 1200 mg per serving, which can benefit those seeking more concentrated herbal support.
  • The product is non-GMO and gluten-free, catering to various dietary restrictions and ensuring a cleaner, more natural supplement choice.
  • Quick-release capsules make it convenient and easy for users to incorporate the supplement into their daily regimen, with the assurance of fast absorption.
  • Piping Rock emphasizes quality. Their products undergo thorough testing for purity and potency, giving consumers confidence in their supplement choices.
  • The supplement is designed to support overall health, particularly beneficial for women's wellness, including potential relief from menopausal symptoms.

Cons

  • Some users might be sensitive to the potent dosage, which could lead to mild side effects such as digestive discomfort.
  • Due to the naturally occurring isoflavones in red clover, the capsules may not be suitable for those with specific health conditions or those avoiding phytoestrogens.

Amazing Formulas Red Clover

Amazing Formulas Red Clover

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Amazing Formulas Red Clover Supplement provides a potent herbal supplement with 430 mg of red clover per serving. Each bottle contains 180 capsules, making it a long-lasting option for those looking to integrate this traditional herbal remedy into their daily health routine. Red clover is known for its natural isoflavones, commonly used to support women's health, particularly during menopause.

The product is manufactured in the USA and adheres to GMP standards, ensuring high quality and safety. It is also non-GMO and gluten-free, catering to various dietary preferences and restrictions.

Pros

  • The supplement offers a significant dose of 430 mg of red clover per serving, which is beneficial for those seeking to address symptoms associated with menopause, such as hot flashes and night sweats.
  • It is manufactured in accordance with Good Manufacturing Practices (GMP), ensuring the product meets high standards of quality and safety.
  • Being non-GMO and gluten-free, it is suitable for individuals with dietary restrictions or those who prefer natural, clean supplements.
  • The capsules are easy to take, providing a convenient way to incorporate the benefits of red clover into daily life.
  • The product is made in the USA, offering an additional layer of quality assurance and supporting domestic manufacturing.

Cons

  • Some users have reported side effects such as nausea and headaches, which may make this supplement unsuitable for everyone.
  • As with many herbal supplements, the results are not immediate and may take some time to manifest, which can be a drawback for those seeking quick relief.

Nature's Answer Alcohol-Free Red Clover Extract

Nature's Answer Alcohol-Free Red Clover Extract

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Nature's Answer Alcohol-Free Red Clover Extract is a liquid herbal supplement designed to support natural mood balance and hormone regulation, particularly for women experiencing menopause. This product uses a cold extraction process to preserve the natural constituents of red clover, a plant known for its isoflavones and other beneficial compounds.

The extract is alcohol-free, making it suitable for those who avoid alcohol. Its concentrated formula provides 2,000 mg of red clover per serving, making it an effective and easy-to-use option for individuals seeking natural support for hormonal changes.

Pros

  • The product offers a potent dose of red clover, with 2,000 mg per serving, making it a strong option for those looking for concentrated herbal support.
  • The cold extraction process preserves the plant's beneficial compounds, ensuring a high-quality extract.
  • Being alcohol-free, it is suitable for individuals who are sensitive to alcohol or prefer to avoid it.
  • The liquid form allows for flexible dosing and easy mixing with water or other beverages, making it convenient for users.
  • Nature's Answer, a reputable brand with a long history, ensures quality through stringent testing and verification processes.

Cons

  • Some users may find the taste of the liquid extract unpleasant, which could deter regular use.
  • Due to its concentrated nature, users must carefully measure doses, which can be inconvenient compared to pre-measured capsules or tablets.
  • There are potential side effects, such as nausea or headaches, which some users have reported.

HawaiiPharm Red Clover Liquid Extract

HawaiiPharm Red Clover Liquid Extract

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HawaiiPharm Red Clover Liquid Extract is a potent herbal supplement that supports various health needs, including detoxification and hormonal balance. Made from certified organic red clover (Trifolium pratense) sourced from Chile, this tincture offers a highly concentrated herb form, ensuring a powerful dosage in each drop.

The product is crafted with a meticulous extraction process that uses organic alcohol, vegetable glycerin, and crystal-clear water, maintaining the integrity and potency of the plant's active compounds. This extract is versatile and can be easily incorporated into water, tea, or juice, providing a convenient way to consume the beneficial properties of red clover.

Pros

  • The product uses certified organic red clover, ensuring a high-quality, natural supplement free from GMOs, gluten, artificial colors, heavy metals, preservatives, pesticides, and fertilizers.
  • The tincture is highly concentrated and offers a powerful dose of red clover, which is beneficial for those looking for effective herbal support.
  • The extraction process respects the plant's natural integrity, using only organic alcohol and vegetable glycerin, enhancing the extract's purity and efficacy.
  • The liquid form allows for flexible dosing and easy incorporation into daily routines, making it convenient for users.
  • The product supports various health benefits, including detoxification and hormonal balance, which can be particularly beneficial for menopausal women or those seeking general wellness support.

Cons

  • The product contains alcohol, which may not be suitable for all users, particularly those avoiding alcohol for health or personal reasons.
  • Some individuals might find the taste of the tincture unpleasant, making it challenging to consume regularly.
  • Some users may need a more relaxed return policy, especially if they are not satisfied with the product after purchase.

Final Words

Among the top red clover supplements reviewed, Nature’s Way Red Clover Blossom Herb is the best choice for menopausal support. This product excels due to its high-quality, non-GMO ingredients and eco-friendly packaging.

It offers 800 mg of red clover per serving, which is a substantial amount that supports hormonal balance and alleviates symptoms like hot flashes and mood swings. The capsules are vegan and free from common allergens, making them accessible to many users.

For those seeking a reliable and natural solution to manage menopausal symptoms, Nature’s Way Red Clover Blossom Herb is an excellent option. Its combination of efficacy, safety, and sustainability makes it a standout choice.

FAQs on Red Clover Supplements for Menopause Support

Is red clover safe to use for all women experiencing menopause?

While generally considered safe, red clover is not recommended for everyone. Women with hormone-sensitive conditions, such as breast cancer or endometriosis, should avoid it due to its estrogen-like effects. Additionally, it is not recommended for pregnant or breastfeeding women.

How long does it take to see benefits from red clover supplementation?

The effects of red clover may take several weeks to become noticeable. Some studies suggest that benefits can be observed after 12 weeks of consistent use, though individual responses may vary​.

Can red clover be used alongside other treatments for menopause?

Red clover can be taken alongside other treatments, but it is important to consult a healthcare provider first. It may interact with other medications, such as hormone replacement therapies and blood thinners, potentially altering their effects​.

References

  • World Health Organization. (2022, October 17). Menopause. WHO. Retrieved from https://www.who.int/news-room/fact-sheets/detail/menopause
  • Abdi, F., Alimoradi, Z., Haqi, P., & Mahdizad, F. (2016). Effects of phytoestrogens on bone mineral density during the menopause transition: A systematic review of randomized, controlled trials. Climacteric, 19(6), 535-545. https://doi.org/10.1080/13697137.2016.1238451
  • Ghazanfarpour, M., Sadeghi, R., Latifnejad Roudsari, R., Khorsand, I., Khadivzadeh, T., & Muoio, B. (2016). Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis. Journal of Obstetrics and Gynaecology, 36(3), 301-311. https://doi.org/10.3109/01443615.2015.1049249
  • Kanadys, W., Barańska, A., Błaszczuk, A., Polz-Dacewicz, M., Drop, B., Kanecki, K., & Malm, M. (2021). Evaluation of clinical meaningfulness of red clover (Trifolium pratense L.) extract to relieve hot flushes and menopausal symptoms in peri- and post-menopausal women: A systematic review and meta-analysis of randomized controlled trials. Nutrients, 13(4), 1258. https://doi.org/10.3390/nu13041258
  • Ehsanpour, S., Salehi, K., Zolfaghari, B., & Bakhtiari, S. (2012). The effects of red clover on quality of life in post-menopausal women. Iranian Journal of Nursing and Midwifery Research, 17(1), 34–40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590693/
  • Chen, L., Choi, J., Leonard, S. W., Banuvar, S., Barengolts, E., Viana, M., Chen, S.-N., Pauli, G. F., Bolton, J. L., & van Breemen, R. B. (2020). No clinically relevant pharmacokinetic interactions of a red clover dietary supplement with cytochrome P450 enzymes in women. Journal of Agricultural and Food Chemistry, 68(47), 12615-12624. https://doi.org/10.1021/acs.jafc.0c05856