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Understanding Antiviral Medications for Viral STDs: Effects, Resistance, and Management

Antiviral Medications for Viral STDs
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Written by Andrew Le, MD.
Medically reviewed by
Last updated May 29, 2024

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Navigating a sexually transmitted disease (STD) is daunting enough. Receiving a diagnosis for a viral STD, however, presents an even more complex challenge. Antiviral medications are the go-to solution for managing most viral STDs. They don’t cure the infection, but they can help manage your condition by controlling the symptoms and preventing it from spreading. You’ll need to work with a healthcare provider to navigate your infection and follow the instructions in the letter. Read on to learn and understand everything you need to know about antiviral treatment for viral STDs.

Key Takeaways

  • Viral Sexually Transmitted Diseases (STDs) require the use of antiviral medications for management, unlike bacterial and parasitic STDs that can be treated with antibiotics.
  • Antiviral medications work by stopping the replication cycle of viruses, thus preventing the virus from multiplying in the body.
  • While antivirals can minimize symptoms and reduce the chances of transmitting the virus, they do not completely cure viral infections.
  • Commonly prescribed antiviral drugs such as Acyclovir, Famciclovir, and Valacyclovir are effective against Viral STDs such as genital herpes, HIV, and hepatitis B and C.
  • What antiviral medication you take and how long you take it depends on the specific viral infection and the individual's health condition.
  • Potential side effects of antivirals range from mild nausea, vomiting, diarrhea, or headache to severe health implications such as kidney problems and allergic reactions.
  • Antiviral resistance, where a virus mutates and becomes less susceptible to antiviral drugs, can be an issue for those with an impaired immune system or long-term antiviral treatment.
  • Regular screening and adherence to prevention measures are essential for detecting and managing STDs effectively.

Viral STDs

Unlike syphilis, gonorrhea, and chlamydia, which are caused by bacteria, the pathogens that cause herpes, HPV, hepatitis, and HIV are viruses—microscopic infectious agents that attach themselves to and take over healthy cells, then replicate and spread. Viral STDs are spread through sexual contact. The virus is dormant in many people, meaning it hasn’t replicated or caused immediate damage. When this happens, you don’t have symptoms, so you can still pass the virus on to another person.

Treating Viral STDs

Sexually transmitted diseases (STDs) caused by viruses present a unique challenge. Most viral STDs don’t have a cure but are lifelong conditions that must be managed with antiviral medications. Some viral STDs, such as Human Papillomavirus (HPV), are not treated at all. HPV, which causes genital warts and can potentially lead to cervical or other types of cancers, often resolves on its own, although doctors prescribe treatment for genital warts and monitor patients for signs of precancer.

Antiviral Medications for STDs

Antiviral medications are used to treat herpes, hepatitis, and HIV infections. They work by stopping the virus from multiplying in your body, giving your immune system a fighting chance to control the virus. Antivirals don’t cure the infection but help manage its symptoms, reduce outbreaks, and lower your risk of transmitting and infecting other people.

Common Antiviral Medications for Herpes

Herpes is one of the most prevalent viral STDs; over 500 million people are estimated to have herpes worldwide. There is no cure for the herpes simplex virus. However, you can manage the symptoms effectively with antiviral medications.

Antivirals primarily help reduce the severity of a herpes outbreak, lessen the frequency of recurrences, and minimize the chances of transmitting the infection to a sexual partner. There are a range of antiviral medications that your primary care provider may recommend, depending on the severity of your symptoms and your overall health. You must speak with health professionals about the most suitable treatment for you.

Acyclovir, Famciclovir, and Valacyclovir are the antivirals prescribed to slow down the growth and spread of the herpes virus, which is responsible for causing not only genital herpes but also cold sores, chickenpox, and shingles. You must take acyclovir as prescribed, usually 2 to 5 times daily for 5 to 10 days.

HIV/AIDS

The most feared viral STD is the Human Immunodeficiency Virus (HIV), which can lead to Acquired Immunodeficiency Syndrome (AIDS). Specifically, HIV is a retrovirus, so the medicines that are central to keeping the virus under control are collectively known as antiretroviral therapy (ART). They also prevent HIV from developing into AIDS, which is more severe. Retrovirals can’t cure HIV/AIDS, but they keep the virus from replicating, so they keep the viral load in the body low, giving the immune system a chance to rebuild and keep you healthy. The proper dosage and medication depend on the stage of your condition, which you and your doctor will determine together. Some of the prescribed medications used to treat HIV and AIDS include: enfuvirtide (T20), emtricitabine, tenofovir, abacavir, rilpivirine, etravirine, efavirenz, dolutegravir, elvitegravir, tipranavir, lopinavir/ritonavir, darunavir, maraviroc, and ibalizumab.

Retroviral medications are not just reactionary; some are preventative. PrEP is taken before sexual encounters with an HIV-positive person to reduce the risk of contracting HIV, and PEP medications are used after an unsafe sexual encounter to reduce the likelihood of infection.

Viral Hepatitis

Viral hepatitis is a group of diseases that cause liver inflammation and often spread through sexual contact. The exact treatment depends on whether it's Hepatitis A, B, or C, which can all be transmitted sexually, and on the severity of the infection. Interferon alpha-2b or pegylated interferon, adefovir, entecavir, tenofovir, and lamivudine are prescribed to manage hepatitis infections.

Can Antivirals Cure Viral Infections?

While bacterial infections can be cured outright with antibiotics, most viral infections can't be eradicated using antivirals. This is because viruses embed themselves into the host cell's DNA, making them hard to target without harming the host cells. Antivirals aim to control the symptoms and prevent the virus from multiplying, thus giving your body's immune system the upper hand.

Can Antivirals Prevent the Spread of Viral Infections?

Yes, antivirals can significantly reduce the chances of transmitting the virus. For instance, in the case of genital herpes, using antiviral medications suppresses the virus, thereby reducing the likelihood of sexual partners contracting the infection. However, they're not 100% foolproof. Correct and consistent use of protection during sexual activity is always advised as an additional measure.

How do you Take Antiviral Medications?

Antiviral medications are available in various forms and can be taken orally, topically (applied to the skin), or through an IV (injected into a vein). Remember, ensure that you follow your healthcare provider's instructions thoroughly.

How Long do you Need to Take Antiviral Drugs?

The length of treatment varies depending on the specific viral infection and the individual's health condition. While some cases might require a single dose of an IV drug, others may necessitate intake of oral medication for a week or longer. In chronic ill conditions like HIV, daily use of antivirals might be recommended for a lifetime to effectively control the virus.

What are the Potential Side Effects of Antivirals?

Just like any other medication, antiviral drugs can also have side effects. These commonly include nausea, vomiting, diarrhea, or headache. However, note that side effects vary widely depending on the specific antiviral and your overall health. Make sure to consult your healthcare professional if any side effects interfere with your daily life.

What is Antiviral Resistance?

Antiviral resistance happens when viruses mutate (change form) and become less susceptible or resistant to the drugs designed to kill them. Overuse or incorrect use of antiviral drugs can fuel the onset of antiviral resistance. It's crucial to take medication exactly as prescribed to avoid contributing to this growing health challenge.

Viral STDs warrant strategic management using antiviral medications, effective counseling, and consistent adherence to prevention measures. Unveiling the layers of antiviral medications helps you understand their role and importance in controlling viral infections. Being well-informed is your first step toward maintaining sexual health, reducing transmission risks, and keeping viral infections at bay.

What is Antiviral Resistance?

Antiviral resistance can significantly impede treating viral infections, occurring when a virus mutates, making your antiviral medication less effective. Antiviral resistance is not common, but it has been documented in patients with herpes and those with HIV who are undergoing suppressive therapy and have been on long-term treatment with Acyclovir, Valacyclovir, and Famciclovir.

If you encounter recurring outbreaks despite treatment, it may indicate antiviral resistance, and your doctor may suggest a viral culture for phenotypic sensitivity to determine if resistance is indeed the cause.

Regular STD testing for prevention

Regular STD testing is a critical part of sexual health, especially if you’re sexually active. Early detection is fundamental in managing STDs effectively. Early detection of any STDs not only helps safeguard your health but also prevents you from spreading the infection to your sex partner(s) and promotes a healthier community.

Conclusion

Antiviral medications are a powerful tool in your fight against viral STDs. But they’re not without their drawbacks. Side effects can range from mild to severe, and there’s always the risk of antiviral resistance. That's why you should communicate with your healthcare provider, get tested regularly, and make informed decisions about your sexual health. Managing STDs is a journey that, with the proper support, knowledge, and proactive steps, you can navigate successfully.

Frequently Asked Questions

Can viral STDs be cured with medication?

Viral STDs/STIs caused by a virus cannot be cured. However, their symptoms can be managed effectively with medication. Conversely, bacterial STDs/STIs can be cured entirely through appropriate antibiotic treatment.

Which STD is managed with antiviral medications?

Herpes, HPV, and HIV are three STDs often managed through antiviral medications. Daily suppressive therapy with an antiviral drug can help reduce the frequency of herpes outbreaks.

Which 3 sexually transmitted diseases have no cure?

Three incurable STDs include HIV, genital herpes, and human papillomavirus (HPV). While these infections cannot be cured, they can be managed to reduce symptoms and transmission risks.

Can you go to jail for not telling someone you have HPV?

Yes, under willful or reckless exposure laws, it's a crime to engage recklessly in high-risk conduct without informing your partner about your STD infection. These laws apply even when transmission of the STD doesn't occur, but the person knowingly had an STD.

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Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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