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Top 9 Best Alpha Lipoic Acid Supplements

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Written by Andrew Le, MD.
Medically reviewed by
Last updated August 26, 2024

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Alpha lipoic acid is a fatty acid that is synthesized in the body and is involved in the production of energy. It is also a very effective antioxidant that also assists in defending the body’s cells against harm due to free radicals. Alpha lipoic acid supplements have recently become a topic of interest because of the reported health benefits such as better glycemic control and anti-inflammatory properties.

It matters for us that we take note of several fundamental factors when it comes to considering the best alpha lipoic acid supplements. As a result, it is significant to start by determining which supplement contains a high-quality, pure alpha lipoic acid. There is always a potential that some of the supplements in the market contain a lower-quality or synthetic form of the said compound and would not be as beneficial.

Another aspect, which is equally important, is the daily dose. Alpha lipoic acid is, for the most part, neutrally balanced, but if taken in large amounts, it can lead to undesirable manifestations of side effects such as stomachache or skin rash. When selecting the best supplement containing alpha lipoic acid, it is essential to check the amount of the ingredient that is safe enough for health consumption.

To be able to offer you the best, we invested hours to make a detailed comparison between the different alpha lipoic acid supplement products.

Top 3 Best Alpha Lipoic Acid Supplements

  1. Nutricost Alpha Lipoic Acid Supplement
  2. Amate Life ALA/ALC High Potency Formula
  3. FORCE FACTOR Alpha Lipoic Acid 600mg Capsules

To offer you the choices of alpha lipoic acid supplements, we vhave looked into some of the products in the market and come up with the most effective one. Alpha lipoic acid is also a powerful antioxidant desirable to help the body fight against stress due to its capacity to generate free radical and inflammation. It can also enhance blood sugar level regulation in the body as well as nerve function. Therefore, we have taken factors like quality, potency, purity, and customer reviews into account when coming up with the following list of alpha lipoic acid supplements.

Nutricost Alpha Lipoic Acid Supplement

The Editor's Choice

Boost your health with Nutricost’s Alpha Lipoic Acid supplement. Enhance your wellness path with high strengths, veggie veggie pills, and independent third-party verified potency. As it is made in an FDA registered, GMP-compliant facility you are sure to receive only the best. Embrace being among millions of people who have embraced the power of vitality – welcome to the road to health!

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In the case of Alpha Lipoic Acid supplements, we would like to share that the Nutricost Alpha Lipoic Acid Supplement is an excellent choice due to its potency and quality.

Pros

  • Provides 600mg of high-quality alpha lipoic acid per serving
  • Vegetarian capsules and 3rd party tested
  • Made in a GMP compliant, FDA registered facility

Cons

  • Some users may experience mild side effects such as stomach upset or skin rash
  • May not be suitable for those with certain medical conditions or taking certain medications
  • Some users may find the capsules difficult to swallow

Since being introduced to the Nutricost Alpha Lipoic Acid Supplement we have been using it for few weeks and it has led to improved health and body wellness. It was observed that the supplement contains a high amount of alpha lipoic acid, which is a beneficial ingredient for the human body.

The vegetarian capsules are easy to swallow and we like considering the fact that the supplement is tested by a third party for quality and for the absence or presence of impurities. We also like the fact that the product is manufactured in a facility that is GMP complaint as well as FDA registered so that we are assured of taking a safe and effective supplement.

Some people may feel nauseous or itch due to the effects of this supplement but other than that, we have not seen unpleasant effects in the use of this supplement. That said, Roveda advises anyone considering the use of this or any other supplement to first consult their healthcare provider if they suffer from an ailment or are on medication.

In conclusion, Nutricost Alpha Lipoic Acid Supplement is one of the best products on the market and we provide our best recommendation to anyone who is in search for the product.

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If you’re looking for a potent antioxidant boost and an energy lift, the Amate Life ALA/ALC High Potency Formula is an excellent choice. This dietary supplement combines Alpha Lipoic Acid and Acetyl-L-Carnitine HCl to help fight free radicals, support cognitive function, and improve overall vitality for both men and women.

Pros

  • Powerful antioxidant support
  • Boosts energy and cognitive function
  • Suitable for men and women
  • High-quality, effective formula
  • Easy-to-swallow capsules

Cons

  • Slight aftertaste
  • Benefits may take time with regular use

Amate Life ALA/ALC High Potency Formula offers a blend of 600mg Alpha Lipoic Acid and 300mg Acetyl-L-Carnitine HCl in each serving. This combination works to protect cells from oxidative damage, improve brain function, and promote healthy energy metabolism. Designed for both men and women, this supplement comes in a 60-capsule bottle, providing a 30-day supply of effective antioxidant support and energy enhancement.

We’ve experienced a noticeable increase in our energy levels and mental clarity since adding this supplement to our routine. The combination of Alpha Lipoic Acid and Acetyl-L-Carnitine HCl has helped us feel more alert and revitalized. While the slight aftertaste took some adjusting, the results have been worth it. With consistent use, the Amate Life ALA/ALC High Potency Formula delivers a sustained boost in vitality and cognitive function, making it a great addition to our health regimen.

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We highly recommend the FORCE FACTOR Alpha Lipoic Acid 600mg Capsules for anyone seeking a high-quality ALA supplement.

Pros

  • High potency with 600mg of ALA per capsule
  • Vegan-friendly and gelatin-free
  • Promotes cardiovascular and cellular health
  • Easy-to-swallow vegetable capsules

Cons

  • Only 60 capsules per bottle, which may not last long
  • Slightly higher price compared to other options

FORCE FACTOR Alpha Lipoic Acid 600mg Capsules deliver 600mg of potent alpha lipoic acid in each serving. This vegan, gelatin-free formula is crafted to support cardiovascular and cellular health by providing strong antioxidant protection. The 60 vegetable capsules are designed for easy digestion and are ideal for those with dietary restrictions. These capsules help improve circulation and promote healthy blood sugar levels, making them a well-rounded addition to our wellness regimen.

Since incorporating FORCE FACTOR Alpha Lipoic Acid into our routine, we’ve noticed enhanced energy and improved overall well-being. The cardiovascular benefits are evident, and the supplement has been gentle on our stomachs. Although the bottle only lasts a month, the superior potency and quality of the product outweigh the cost. If you’re looking for reliable ALA support for heart health and cellular protection, this is one of the best options we’ve tried.

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This great Alpha Lipoic Acid supplement, NOW Supplements Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine®, Extra Strength, 120 Veg Capsules is one you will surely want to check out.

Pros

  • This supplement is extra strength, containing more alpha lipoic acid per capsule than most other supplements on the market.
  • It's made by a reputable company that's been in business since 1968.
  • It's certified kosher, dairy-free, egg-free, gluten-free, nut-free, soy-free, and vegan/vegetarian.

Cons

  • Exposure to heat or sunlight may lead to melting/damage of the product, so it's important to be available during the product delivery.
  • The capsules may be difficult to swallow for some people.
  • Natural color variation may occur in this product.


Recently we started taking this alpha lipoic acid supplement and we can say it works wonder in just few weeks. Getting enough sleep has contributed towards better health outcomes as we experience more energy and less inflammation. Also, we have not complained that it contains natural ingredients and is not tested on animals and has no agents like soy, dairy, or gluten.

What I would like to draw attention to is that they are relatively large capsules, which might be a problem in the case of people who will struggle to swallow the given quantities of the preparation. Furthermore, it is not suited for areas that are exposed to heat or sunlight as it might melt or be damaged in the process and requires availability upon receipt of the product.

All in all, we believe that NOW Supplements, Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine®, Extra Strength, 120 Veg Capsules is a great product and would strongly recommend it to anyone who wants to take alpha lipoic acid supplement.

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This great Alpha Lipoic Acid supplement, NOW Supplements Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine®, Extra Strength, 120 Veg Capsules is one you will surely want to check out.

Pros

  • Helps promote the body's antioxidant defenses and protect against oxidative stress
  • Triple strength formula for maximum effectiveness
  • Non-GMO, gluten-free, and vegan

Cons

  • No returns, so be sure you want the lower than recommended dosage of 600mg
  • Some users experienced heartburn when taking without food
  • May not work for everyone

Recently we started taking this alpha lipoic acid supplement and we can say it works wonders in just few weeks. Getting enough sleep has contributed towards better health outcomes as we experience more energy and less inflammation. Moreover, what we really enjoy is the fact that it is an all-natural product and does not contain any of the most common allergens.

What I would like to draw attention to is that they are relatively large capsules, which might be a problem in the case of people who will struggle to swallow the given quantities of the preparation. Furthermore, it is not suited for areas that are exposed to heat or sunlight as it might melt or be damaged in the process and requires availability upon receipt of the product.

All in all, we believe that NOW Supplements, Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine®, Extra Strength, 120 Veg Capsules is a great product and would strongly recommend it to anyone who wants to take alpha lipoic acid supplement.

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If you want a pure, highly potent Alpha Lipoic Acid that is stabilized and has excellent absorption rate, then IMMUNOVITES stabilized R-Alpha Lipoic acid is the supplement that is right for you.

Pros

  • The product contains TRUE net weight of 600mg per serving.
  • It is stabilized and has high potency.
  • It has up to 40x more absorption.

Cons

  • It is a bit pricey compared to other alpha-lipoic acid supplements.
  • Some users may experience stomach upset when taking the supplement.
  • It is not suitable for people with thyroid problems.

Now for few weeks we are using IMMUNOVITES Stabilized R-Alpha Lipoic Acid, and found a lot of changes for better in our health region. It is in a forms that can easily be ingested in the body and we did not have any side effects after taking the supplement.

Product: A nutrient supplement that fosters healthy neuropathy, glucose, level regulation, and supplies a power anti-oxidant response. It also has protective roles on the nervous system hence useful for diabetic neuropathy and tingling of hands and feet.

I must however say that one of the things that I found good about this product is that it does not contain S-alpha lipoic acid, which I came to discover is only a useless and slowing product. The bar ordered “S”-Alpha Lipoic Acid is actually “STABILIZED (Na) R-Alpha Lipoic Acid” and the facts behind the dietary supplement facts box do not include “S”-Alpha Lipoic Acid.

In our estimation, it is the best supplement to use when one would want to use a stabilized and highly potent form of alpha lipoic acid. Unfortunately, it costs a little on the higher side but I recommend it given that it generally has a positive impact on our health.

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If you are searching for a supplement that can help in the functioning of the liver, enhance the brain’s performance, and safeguard the nerves, Thorne Alpha-Lipoic Acid has got you covered.
Pros

  • Thorne Alpha-Lipoic Acid has important nerve protective effects.
  • It supports liver health.
  • It helps maintain mental sharpness.

Cons

  • The supplement can have a strong taste.
  • The serving size is one capsule, but the directions say to take 2 to 3 times a day.
  • It may not be suitable for people with certain allergies or dietary restrictions.

I have used Thorne Alpha-Lipoic Acid and indeed it has been beneficial in enhancing my wellness status. We acknowledge the fact that Thorne products do not use genetically modified material and its products do not contain gluten, artificial preservatives, stearates, wheat, rye, barley, eggs, nut or GMO’s and is sourced from natural products only.

We also care about the reputation, Thorne is known to be a company with a good reputation, which cares about the quality and the science behind all the supplements. For your information, Thorne products are used by 45 000 health care providers and 100 and over professional teams and U.S. Olympic teams. This makes Thorne the only supplement manufacturing company that has a direct working relationship with Mayo Clinic when it comes to wellness studies and information creation. Their products are produced in Summerville,South Carolina.

In conclusion, if you are in search of a good, safe, and effective alpha-lipoic acid supplement that can serve to help your liver and boost your brainpower to boot while helping to shield your nerves, then Thorne Alpha-Lipoic Acid could just do the trick.

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If you are searching for an alpha lipoic acid supplement, you might want to look into NOW Supplements Alpha Lipoic Acid.

Pros

  • Supports glutathione production
  • Can function in both water and fat environments
  • Recycles antioxidant vitamins C and E

Cons

  • May arrive warm during summer months
  • Contains rice flour
  • Some may prefer a higher dosage

NOW Supplements Alpha Lipoic Acid has been in circulation for a while now and we have been using it for some weeks now and we can say it has not disappointed. I may also speak for all of us that we have been experiencing better physical health and think that this supplement keeps us healthy.

Another thing which we found interesting about this product is that it optimized the production of glutathione. Vit C helps the body to eliminate toxins and reduce the effects of free radicals in cells while glutathione is another antioxidant responsible for defending cells against damages caused by free radicals. NOW Supplements Alpha Lipoic Acid can be beneficial for supplementing our body with glutathione which is an essential component for a healthy and vibrant body.

One thing that we found nice about this supplement is that it can operate in both aqueous and lipid solutions. This means that it can assist in the elimination of dangerous free radicals in the aqueous phase as well as lipid phase in the cell. This makes it a unique and effective nutrient capable of shield cells in different parts of the body.

Last, we are glad that this supplement has potentially of the ability to recycle antioxidant vitamins C and E, suggesting that this preparation can help prolong the activity of the mentioned vitamins, which is always beneficial for the body and the state of health.

All in all, NOW Supplements Alpha Lipoic Acid is a perfect antioxidant for anyone who wants a supplement of alpha lipoic acid.

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All in all, Natrol Alpha Lipoic Acid Time Release Tablets are highly recommended for those who want a potent antioxidant supplement.

Pros

  • Provides antioxidant protection that helps cells in the human body rejuvenate
  • Neutralizes free radicals, which makes it a powerful antioxidant
  • Reduces oxidative stress, which helps to protect against age-related damages

Cons

  • May cause upset stomach issues in some individuals
  • Pills are larger than other brands
  • May not work for everyone


Natrol Alpha Lipoic Acid Time Release Tablets is a fast acting antioxidant that works in synergy with other supplements taking an active part in the antioxidant defense system fighting against oxidative damage due to aging and environmental factors. It is designed with controlled release technology that allows the slow and steady methodical release of ALA in the body within 12 hours giving a plasma antioxidant and energy boost. unlike most antioxidants vitamins such as Vitamin C & E, Natrol Alpha Lipoic Acid active both in water and fat environments and, therefore, is more powerful.

Since we have used this supplement before we know that it can help to reduce the amount of damage that the cells in our body receive from oxidation. As we have been using this supplement, we have observed increased vitality and improvement in some aspects of our general health.

A possible drawback to using Natrol Alpha Lipoic Acid Time Release Tablets is that it may trigger stomach discomfort in some people. However, it should also be noted that the pills are of a much larger size than those used in other brands and this can be a problem for some people who will find it hard to swallowing large pills. The last point is the fact, which every man who takes the described supplement knows, unfortunately it doesn’t work for everyone.

In conclusion, Natrol Alpha Lipoic Acid Time Release Tablets is a product we strongly recommend for anyone who needs a great source of antioxidants that could prevent and reduce damages caused by aging and regenerate deceased cells.

Buying Guide

If you are choosing the best supplement that contains alpha lipoic acid, there are some important things that you have to consider. Here are some features to look for when selecting a product:

Form and Dosage

Alpha lipoic acid products can be taken in capsules, tablets, and powder forms for those who require supplement intake. Those that come in capsules and tablet form are convenient to swallow and may be taken in more than one strength. While it is more convenient to take liquids, powders can be sprinkled on food or booze and take longer to kick in but they are portable and preferred by most people.

It is also important to take time and identify the correct dosage of the supplement to be consumed. It suggested for human consumption of this antioxidant that it is taken between 300mg and 600mg per day. In some cases volume can be taken, but for this it is necessary to consult with the doctor and find out the right amount of vitamins.

Purity and Quality

There are many alpha lipoic acid supplements available on the market today in the form of pills, and when choosing one, it is important to use one that is pure and has quality. Concentrate mostly on supplements made in a factory that adheres to the GMP rules and has been endorsed by a third party.

This can be achieved by ensuring that the supplement is in its natural form while there are other forms like synthetic alpha lipoic acid. Neutral Alpha lipoic acid is more active when derived from natural sources, and is easily absorbed in to the human body.

Additional Ingredients

While alpha lipoic acid is basic, certain brands that synthesize this compound may include other substances, vitamins, minerals, or other antioxidant forms. However, as with any additional ingredients, it is crucial to determine that their incorporation in the product does not have adverse consequences and is efficient.

After that it is worth to check the label for any other ingredients and make a research whether they are actually needed or are beneficial for you in any case.

Price

Whenever people are shopping for a product, price is always an important factor especially with a supplement. Therefore while choosing the supplement it’s not only of high standard but also within the prescribed budget.

Make a comparison and use the amount in pictures as well as read reviews to have the best value of your money.

If these factors are taken in consideration, one will be in a position to select an alpha lipoic acid supplement that is safe, effective, as well as catering for the individual’s requirements.

Frequently Asked Questions

What is the best form of alpha-lipoic acid to take?

There are several forms of alpha lipoic acid, but the best one to use is the called R-ALA (R-Alpha Lipoic Acid). This one is the naturally occurring form of alpha-lipoic acid and is more potent than the synthetic compound- S-ALA (S-Alpha Lipoic Acid).

Which form of lipoic acid is best for neuropathy?

We know that the right form of lipoic acid in managing neuropathy is R-ALA (R-Alpha Lipoic Acid). There is evidence that points to its effectiveness in relieving nerve dysfunction and pain and numbness relating to complications of diabetes well.

How much alpha lipoic like acid is recommended for neuropathy?

For neuropathy, alpha-lipoic acid is given in dosages ranging between 600 and 1800 mg daily. Initially, small dosages of the drug should be administered, and then, the dosage should be gradually increased to avoid side effects.

What to avoid when taking alpha-lipoic acid?

It is recommended not to take alpha-lipoic acid with food since it may decrease its absorbability. It should not be taken by pregnant and breastfeeding women or those who have thiamine deficiency disorders.

Alpha Lipoic Acid reviews for neuropathy

Some evidence indicates that alpha-lipoic acid is beneficial in treating diabetic neuropathy because it can enhance the nerve function of affected body parts and decrease the pain and numbness to which diabetic patients are prone. Though it has some promising effects, it might not suit everybody, it is thus recommended that one should seek medical advice before integrating any new supplement.

Alpha Lipoic Acid brand reviews

Different brands of alpha-lipoic acid can be purchased or availed in the market today. The most common ones include Doctor’s Best, Jarrow Formulas, as well as NOW Foods, among others. While selecting the aluminum extrusions, it is suggested that one should select a right brand and look for third-party certification for quality assurance.

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Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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