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Top 9 Best Anti Itch Creams

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Written by Andrew Le, MD.
Medically reviewed by
Last updated July 29, 2024

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Itching can be very uncomfortable and often people can suffer from it irrespective of how old or young they are or regardless of their sex. Some of the major causes of itching include; bug bites and sting, allergy, different skin conditions, and skin dryness. There are several remedies for itching, for which anti-itch creams take the day since they are convenient to use and efficient.

These creams relieve the condition since they have an effect of actuating the nerve endings in the skin thus decreasing the extent of itching. They also include substances that have moisturizing and anti-inflammatory effect on the skin, which enhances its calmining effect and decreases redness.

We dedicated considerable time and effort to offer a comparison of the top anti-itch creams to find out which ones are safe, effective and offer superb itch relief. Here are best anti-itch creams on the market.

Top 3 Best Anti-Itch Creams

  1. Cortizone-10 Maximum Strength Anti-Itch Cream with Soothing Aloe
  2. Truremedy Naturals - Remedy Balm with Tea Tree Oil
  3. Benadryl Extra Strength Anti-Itch Cream

We know the frustration and the inconveniences that come with the itchy skin. This is why we have compiled a list of the top anti-itch creams that would help you to effectively get rid of the itch. These creams will help you ease that itch you’ve had for the longest time.

Cortizone-10 Maximum Strength Anti-Itch Cream with Soothing Aloe

Editor's Choice

Receive fast and powerful itch and skin discomfort relief with Cortizone-10 Maximum Strength Anti-Itch Cream. Helps provide rapid, lasting relief without the need for a prescription This product is enriched with aloe, recommended by a dermatologist.

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This six-ounce tube is ideal for people seeking a product that immediately stops itching that is caused by eczema, psoriasis, poison oak, ivy, sumac, and many more, and this product is none other than Cortizone-10 Maximum Strength Soothing Aloe Anti-Itch Cream.

Pros

  • Itching is responded to by initially administering a contact to work on the skin inflammation.
  • Contains 1% hydrocortisone, the maximum strength over-the-counter itch reliever.
  • Gives quick itch relief in under 10 minutes and the formula lasts for hour.

Cons

  • May cause allergic reactions in some users.
  • Not suitable for children under 12 years old.

Lately, we used Cortizone-10 Maximum Strength Soothing Aloe Anti-Itch Cream and we were satisfied with the sped up effect of this medication. The cream begins to sooth itching as soon as it gets on the skin and is made from 1% Hydrocortisone, the maximum strength cream that can be purchased over the counter without a prescription. We also liked that it treats itch in under 10 minutes and lasts for hours, making it great for use in the event that one is on the move.

However, over application of this cream can thin down the skin hence the application should be done as recommended. It is also contraindicated in children below the age of twelve and may provoke an allergic reaction.

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If you are seemingly in search of a quality anti-itch cream that guarantee quick and extended relief, then the Truremedy Naturals – Remedy Balm with Tea Tree Oil is the best bet.

Pros

  • The localized nature of the balm’s application is advantageous since it can be easily applied to the site of inflammation.
  • Due to its portable and small package bottle of balm, one can easily fit it in their bag and get access to it always when in need.
  • Tea tree oil is an antifungal that has been used previously to decrease inflammation and itching linked too a psoriasis flare.

Cons

  • Potential skin sensitivity.
  • it is not a cure for psoriasis.

As users of Truremedy Naturals’ Remedy Balm with Tea Tree Oil, it would be impossible not to rave about the product. Starting from the common boo-boos of scraped knees and elbows to the itch of bug bites and general skin rashes, this balm has made itself almost indispensable in our daily routine. Tea tree oil, together with other natural products used in the making of this conditioner, gives users a refreshing and calming feel after application of the conditioner. It is produced as a solution for many skin problems due to its capacity to relieve redness and inflammation of the skin.

Also, worth knowing about the company is that they focus on the quality and purity of the products. Realizing that this balm does not contain toxic components and artificial colors or preservatives, is rather comforting especially when we apply it on the tender skin of our babies or during the night.

The texture is silky and does not include any substance of grease; therefore, unlike most body lotions it can be absorbed very rapidly. Whether out in the wilderness or dealing with typical life incidents at home, this Truremedy Naturals Remedy Balm has been a beast of relief regardless of the hour in which it is required.

Order Benadryl Extra Strength Anti-Itch Cream Now!

If you need quick aid from pain and itching resulting from insect bites, burns, sunburn, and other skin rashes, then Benadryl Extra Strength Anti-Itch Cream is among the best remedies you can go for.

Pros

  • Gives swift and cooling relief from the pains and itching
  • It contains 2% diphenhydramine HCI topical analgesic to ensure that the patient gets adequate relief.
  • Known for the healing of oozing, weeping, poison ivy, poison oak, and poison sumac rash

Cons

  • May not work for severe itching
  • Can cause drowsiness in some users

We have used Benadryl Extra Strength Anti-Itch Cream for itching due to skin rash, and insect bites, and it works very efficiently with quick results. The sensation of coolness is calming and bid helps in relieving itchiness, and pain in the affected region.

The cream is easy to apply and it penetrates the skin quickly without leaving behind an oily feeling. It is also nice to have with you especially when going for a camping, going for a hike or even walking with the family.

Although it is not ideal for extreme itching, it is very useful for less severe itching and pain. But it should be noted that for some people it may act as a sedative, which is why it must be used carefully.

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When you are considering an anti-itch lotion that can give you quick relief and that relief will last for a while, give the CeraVe Anti-Itch Moisturizing Lotion with Pramoxine Hydrochloride a try.

Pros

  • Gives quick and lasting relief in ten minutes and lasts for eight hours
  • A light textured product that penetrates the skin readily to moisture it through giving it a silky fee
  • It is gentle, yet effective for brightening the skin and is formulated with 3 essential ceramides to help maintain the skin’s natural barrier.

Cons

  • It is a bit expensive
  • Does not work on severe eczema

This lotion is dermatologist endorsed and the satisfaction is almost immediate and lasts for 8 hours amid usage. This gel is of a water-like consistency that sinks into the skin without leaving behind any oily residue. It is enriched with 3 Ceramide that effectively help in rebuilding and strengthening skin’s natural barrier.

Pramoxine Hydrochloride 1% that works as an anti-itching agent helps in giving a quick and long-lasting temporary relief from itch. In addition, the lotion includes the following ingredients; Niacinamide to reduce irritation, and Hyaluronic Acid to maintain the skin’s moisture.

CeraVe Anti-Itch Moisturizing Lotion is gentle and hypoallergenic thus can be used on the face, body, and hands for relieving itchiness. This lotion is free from fragrances, steroids and it is non-comedogenic thus suitable for delicate skin.

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Cortizone-10 Maximum Strength Ultra Soothing Anti-Itch Cream guarantees fast itch relief in case you have seborrheic dermatitis, itchy skin, skin rash or insect bites and so on.

Pros

  • Gives a quick cessation to itch and inflammation
  • Includes 10 moisturizers and one aloe to renew skin and make it soft.
  • The formula is non irritating, fragrance-free, and dye-free.

Cons

  • Not recommended for severe skin conditions
  • May not be effective for all types of itch

We have used Cortizone-10 Maximum Strength Ultra Soothing Anti-Itch Cream in cases of simple rashes as a result of insects’ bites and the product is effective in reducing itchiness as well as inflammation. The cream mainly has hydrocortisone which is 1% cream, and this is the maximum strength anti-itch formula that is over the counter.

This is one of the significant features of this cream since it consists of 10 moisturizers aloe for the skin’s healing function. It is also for maximum strength, nonirritating, fragrance-free and dye-free making it suitable for those with sensitive skin.

When used for rash and itching due to skin irritations this cortizone 10 maximum strength ultra soothing anti-itch cream is effective but it might not be appropriate for severe skin conditions. Long-term application also results in skin thinning thus it should be applied under prescription. Also it may not work for all form of itch.

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CeraVe Itch Relief Moisturizing Cream is a perfect cream for those persons who seek to find an anti-itch treatment that will start working instantly and for a long time.

Pros

  • Brings quick and near-instantaneous relief for symptoms and the duration lasts for up to 8 hours.
  • Formulated with 1% Pramoxine Hydrochloride for rapid and sustained temporary relief of itchiness.
  • Fragrance-free, steroid-free, and non-comedogenic.

Cons

  • May not be effective for severe cases of itching
  • Some users find it too thick

We recently tried this anti-itch cream and were happy with the fast results that the cream gave us. It’s luxurious, unleaded and smooth formula penetrates the skin readily and leaves it silky, without an oily appearance. It is also inoffensive and mild meaning that it can be used on the face, the entire body, and hands to help reduce itching for a while.

This cream is equipped with 1% Pramoxine Hydrochloride ; the active anti-itch ingredient that delivers fast and long-lasting itch relief. The product also has three effective forms of ceramides which helps to rebuild this protective skin barrier and has an emollient based cream that feels quite luxurious on the skin.

We also like the fact that this cream has no perfume, has no steroid, and does not clog the pores of the skin. Further, it is endorsed by the National Eczema Association and remains made from three central ceramides (1, 3, and 6-II to help reconstruct the skin’s barrier.

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If you need an effective anti-itch cream, which can give you a pretty long-lasting effect, CeraVe Hydrocortisone Anti-Itch Cream will do that.

Pros

  • Most effective 1% cortisone cream for scratching due to skin conditions.
  • It contains the necessary ceramides that are needed to reconstruct the functioning CER layer of the skin.
  • Non-scented and gentle to skin, this product has been granted the NEA Seal of Acceptance.

Cons

  • Small 1 ounce tube may not last long
  • May not work for severe or chronic itching

We tested CeraVe Hydrocortisone Anti-Itch Cream and were pleased with it ability to help stop itching related to minor skin inflammation and irritation, insect bites, and effects of sunburn. The cream has active ingredient of 1 % hydrocortisone which is effective in easing skin flare-ups and itching of extra dry skin and eczema.

One of the best strengths of this product is that it contains ceramides which help to rebuild the skin’s barrier. This cream also has hyaluronic acid to boost the skin’s ability to maintain its moisture and niacinamide for the skin/calming effect. It is non-scented, gentle and does not clog the pores and thus we found this factor quite useful.

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If you are in search of a good, realiable anti-itch cream, count on Benadryl Original-Strength Itch Stopping Anti-Itch Cream.

Pros

  • Alleviates most outdoor itches and irritation.
  • Relieves itching which may be due to insect bites, mild burns, and irritation.
  • The formula contains1% diphenhydramine hydrochloride; a topical pain reliever for the management of pain.

Cons

  • May not work for severe itching
  • Tends to leave a white residue on the skin

We have applied this cream while on a camping trip and while hiking and it has been very effective in relieving the itching of the bites as well as the minor skin inflammations most of the times within a short span of time. It is used for solving the problems of oozing and weeping associated with poison ivy, poison oak, and poison sumac, and that’s why it is a must-have item when one is outdoors.

The formula consists of one percent, diphenhydramine hydrochloride, topical analgesic pain reliever, and 0. 1% zinc acetate skin protectant which can be used as a treatment for a damaged skin. We understand that this cream is for children aged 2 and above making it suitable for use by children hence suitable for families.

Even though the cream is relatively effective in the usual cases of itching, it may not be so appropriate to use when the itching is severe. However, there was also observed that it often has a Bleaching effect on the skin and if a large amount of solution is used it will leave a white powder residue on the skin. Lastly, if it is applied in large quantities, it causes drowsiness hence should be used under recommendation of the doctor.

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If you were intending to purchase an effective anti-itch cream there is no better product than the Aquaphor Itch Relief Ointment.

Pros

  • Gives you long-lasting relief for as long as 12 hours
  • It has been clinically tested and can easily relieve itchiness caused by indoor as well as outdoor activities.
  • It is mild for the sensitive or inflamed skin and provide the maximum strength comfort probability.

Cons

  • May not be effective for all types of skin irritation
  • It is a bit expensive

We have actually tried this ointment on our skin on mosquito bite relief, bug bite relief and poison ivy relief which really works. The 1% hydrocortisone anti-itch ointment has an instant relief from itch and irritation due to skin reaction, insect bites, psoriasis, skin rashes, eczema, and poison ivy.

The gentle formula of the product does not contain any fragrances and parabens and the product is suitable for anyone including kids with sensitive skin over the age of two. Although it is an ointment, it is very easily spreadable and gets easily absorbed in the skin without leaving the skin feeling greasy and is indeed very silky and does provide a onetime long lasting relief to the skin.

Overall, if you are still struggling in finding an effective anti-itch cream that will provide prolonged scratch’s relaxation, then Aquaphor Itch Relief Ointment should be your first choice.

Buying Guide

Active Ingredients

It is the active ingredients in an anti-itch cream that determine the efficacy of the cream. You need to look for creams with additives like hydrocortisone, pramoxine or, menthol for the best results. The following are some of the ingredients that can help with itchiness, inflammation, and pain. Always take a look at the ingredients list and look out for any possible allergens or irritant. Be sure to read the labels paying attention to possible allergens and other skin irritant

Formulation

These anti-itch creams have different forms; there are lotions, gels and ointments. Depending on which part of the body you will apply the cream, select an formulation that is easy to apply and does not leave the skin oily. For instance, a lotion may be more appropriate for all over the body while ointment is more suitable for point like areas.

Strength

Purchasing an anti-itch cream is quite important but the strength of the cream is very vital to consider. A stronger cream may work well and give better relief than a relatively weaker product, but this comes with a disadvantage of having more side effects. Just in case religious an over the counter cream with a higher strength you should always advise a doctor before using one.

Additional Features

There are certain creams that can have other properties such as moisturizers and skin protectants added to them for treating itchy skin. It may prove to be useful when one has dry or sensitive skin or when one finds that their skin easily gets irritated. It is important that you take time to read the labels to be on the lookout for any other extras that could be useful to you.

Price

Price is a factor that is always considered especially when it comes to the acquiring of any product. Anti-itch creams might be available at very different prices, that’s why, you should take into consideration price factor and afford to buy a certain product. Do not be deceived by high prices thinking that you are getting a better product in the process. Find a product that you require and one that can be afforded in terms of its price.

Frequently Asked Questions

What is the best cream for extreme itching?

As for the extreme itching, it is necessary to select the cream with a strong anti-itch ingredient, for example, hydrocortisone. Among the best creams for severe itching are Cortizone-10 Maximum Strength Anti-Itch Cream with Soothing Aloe, Truremedy Naturals - Remedy Balm with Tea Tree Oil, and Benadryl Extra Strength Anti-Itch Cream.

What cream do dermatologists recommend for itchy skin?

Various creams that may be recommended by dermatologists to fight itchiness may include Cortizone-10 Maximum Strength Anti-Itch Cream with Soothing Aloe, Truremedy Naturals - Remedy Balm with Tea Tree Oil, and Benadryl Extra Strength Anti-Itch Cream.

Which anti-itch cream is best for hives?

While choosing the anti-itch cream to treat hives, one should go for a cream that has diphenhydramine as the active ingredient. These are some of the creams for hives relief; Benadryl Anti-Itch Cream 1 Ounce, Aquaphor Itch Relief Ointment, and CeraVe Hydrocortisone Anti-Itch Cream.

Which anti-itch cream is best for mosquito bites?

Mosquito bites are awful because they become very itchy and there are creams that are very useful for that as well. The creams that give relief from the itching due to mosquito bites are the following: Cortizone-10 Maximum Strength Anti-Itch Cream with Soothing Aloe, CeraVe Hydrocortisone Anti-Itch Cream, and Truremedy Naturals - Remedy Balm with Tea Tree Oil.

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Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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