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Top 13 Best Nattokinase Supplements

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Written by Andrew Le, MD.
Medically reviewed by
Last updated November 5, 2024

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Nattokinase is an over-the-counter cob digesting enzyme from natto which is a fermented soybean product origination from Japan. Despite it not being scientifically accepted as a cure for any ailment, it has become widely used in recent years, especially because of the perceived health benefits it has as a clot prevention agent for the circulation of blood in the body. Thus, more individuals are in search of the top nattokinase supplement to use for boosting up their way of life.

Most significantly in the selection of a nattokinase supplement, special attention should be paid to the concentration or the strength of the supplement being purchased. They can range anywhere from 50mg of nattokinase up to 2,000 mg of it per serving in different supplements. The effectivity of nattokinase also depends on the potency of the enzyme, and this will have to be evaluated.

We’ve reviewed many different nattokinase products and explored various companies, and have defined the cream of the crop. In the following article, I will present an overview of the positive effects normally associated with nattokinase and guide features to bear in mind when shopping for the supplement. We will also reveal our recommended nattokinase supplement brands/sites after the whole assessment.

Top 3 Best Nattokinase Supplements

  1. Utzy Naturals Nattokinase
  2. Nutricost Nattokinase 2,000FU, 120 Capsules
  3. Bio Absorb Nattokinase Supplement

Here, we’ve reviewed the most discussed nattokinase supplements whose availability we’ve confirmed using extensive research. Nattokinase is an enzyme that is separated from natto a well-known Japanese food product made from soybean jelly. It has various prospects that are advantageous in promoting cardiovascular health, blood vessels, and decrease inflammation. Consequently, given a base of numerous choices one can make, it becomes quite a daunting task to make the right selection.

Utzy Naturals Nattokinase

The Editor's Choice

This anti-aging product is Utzy Naturals Nattokinase, which comes with 60 capsules in a bottle, a worthy investment for a healthy heart. It has positive effects on my circulation health which boosts my daily energy levels. In line with my transparency and quality, I appreciate Utzy’s commitment to purity. Of course, effects can differ, but for this supplement, they remained true to the dedication and provide top-notch cardiovascular care.

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On this quest to promote health and wellness awareness, I came across this product from Utzy Naturals called Nattokinase with incredible benefits for my everyday supplement regimen. Being vegan and gluten-free, it paints a perfect image of the organic supplement that I’m willing to immerse myself in with all the specifics in check.
Pros:

  • Vegan-friendly, gluten-free, and suitable for my dietary preferences
  • Supports cardiovascular health and circulation
  • Each bottle contains a substantial 60 capsules
  • Manufactured with a focus on purity and potency
  • Non-GMO formulation aligns with my commitment to natural supplements

Cons:

  • Individual results may vary, and it's advisable to consult with a healthcare professional.


Because the containers come with 60 capsules each, I am making a long-term investment in the wellbeing of my heart by taking Utzy Naturals Nattokinase. I have found this supplement to be very helpful in terms of my circulatory needs which is very essential in day to day functioning.

Utzy Naturals’ commitment to efficacy and safety can be seen in the Nattokinase supplement it has produced. I especially love how this brand practices honest labeling on their products and focus on the quality of the ingredients they use. This aligns superbly well with the fact that I consider supplements that are effective and natural in the best way to go.

It is for this reason that while results may differ from person to person, Utzy Naturals Nattokinase serves as a testament to the company’s dedication to providing a superior product designed to support the health of the cardiovascular system.

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Nutricost Nattokinase 2,000FU is one of those best available options for consumers, who prefer to take a quality nattokinase supplement.

Pros

  • Provides 2,000FU of nattokinase per serving
  • Comes with 120 servings per bottle
  • Non-GMO, gluten-free, and vegetarian-friendly

Cons

  • May not be suitable for those with blood clotting disorders
  • Some users might experience mild side effects
  • Not suitable for children under 18 years old

So far, Nutricost Nattokinase 2,000FU has taken few weeks on us and we actually appreciate the experience. Indeed, as the label also shows, it has about 160 fu/ serving of nattokinase which is good for the heart. It is also important to note that the product is free of GMOs, has no gluten and is vegan, so it will fit into almost anyone’s nutritional program.

Just to note, it is also imperative to establish the fact that this supplement may not be safe to use for those who have blood clotting conditions. Furthermore, there may be certain adverse reactions including mild from nausea to headache. You should always get in contact with a doctor if you are thinking about beginning a new supplement program.

Lastly, considering the powdered forms of nattokinase, we believe Nutricost Nattokinase 2,000FU is a good option for anyone who wants to improve their cardiovascular health and purchase a nattokinase supplement of high quality.

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We highly recommend Bio Absorb Nattokinase Supplement for anyone seeking a potent, long-term solution to support cardiovascular health.

Pros

  • High potency (2,000 FUs)
  • Economical 400-day supply
  • Non-GMO, vegetarian-friendly
  • Sourced from traditional natto extract

Cons

  • Capsule size may be large for some
  • Contains only nattokinase, no additional heart-health ingredients

Each Bio Absorb Nattokinase Supplement capsule contains 100 mg of nattokinase enzyme and offers the consumer 2,000 FUs for healthy blood circulation. Derived from natto, a Japanese food item that has been associated with positive effects for the heart, it is non-GMO and vegan friendly.The packaging comes with 400 capsules, and with the recommended dosage, it means that the supply will last one more year. Bio Absorb’s focus on clean-label sourcing guarantees the highest levels of purity and quality for every capsule.

Nattokinase by Bio Absorb is highly effective in enhancing circulation and the health of the cardiovascular system. The regular users have reported increased blood circulation in their bodies and no more feeling of drowsiness. Its high FU level, contribute to supporting blood viscosity and natural blood clot’s dissolving, thus it is suitable for heart patients.

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When it comes to maintaining heart health and optimal blood pressure, we’ve found FORCE FACTOR Nattokinase 2000 FU to be a standout choice. This supplement supports blood circulation and cardiovascular health with its potent nattokinase formula.

Pros

  • High potency of 2000 FU per serving
  • Non-GMO and vegan-friendly
  • Gelatin-free vegetable capsules
  • Supports healthy blood circulation and blood pressure

Cons

  • Higher price point compared to some other nattokinase supplements
  • Limited information on long-term effects

FORCE FACTOR Nattokinase 2000 FU boasts several key features. Each bottle contains 90 vegetable capsules, which are free from gelatin, making them suitable for vegans. The nattokinase used in this supplement is derived from fermented soybeans, ensuring a high-quality and natural approach to supporting cardiovascular health. The supplement is designed to promote healthy blood circulation and maintain healthy blood pressure levels.

We’ve noticed that incorporating FORCE FACTOR Nattokinase 2000 FU into our routine has had a positive impact on our overall heart health. We’ve experienced improved circulation and a feeling of well-being, which aligns with the product’s claims. The absence of gelatin and use of vegetable capsules are added bonuses, making it a great option for those with dietary restrictions.

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If you are interested in using a supplement that can support the cardiovascular health of the human body, we highly recommend that you purchase the Double Wood Supplements Nattokinase Supplement.

Pros

  • Supports circulatory system health
  • Derived from fermented soybeans for natural ingredients
  • Two month supply for convenience

Cons

  • May contain trace amounts of soy, not suitable for those with soy allergies
  • No added flavors, may have a strong taste
  • May not be suitable for everyone, always consult with a healthcare professional

The Double Wood Supplements Nattokinase Supplement is totally effective for all people who wish to improve the health of circulatory system. This product is extracted from fermented soybeans and contains nattokinase an enzyme that might tend to support the circulation by reducing the plasma amount of specific proteins involved in circulation.

This supplement comes packed in a bottle with enough capsules to last for 2 months if used as directed and the amount of capsules take in a single time is 120. However, as this flavouring is extracted from soy, it must be noted that there could be a slight hint of soy in it as well. Soy lecithin is used in this supplement and therefore, individuals with soy intolerance should avoid this supplement.

A component that supplements the recipe itself may have a very distinct, or no added flavor at all to it. It is essential to see a doctor before they start supplementing with it since it might not be safe for everyone.

All in all, the Double Wood Supplements Nattokinase Supplement is quite suitable for individuals in need of the enzyme to maintain the heart health.

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Doctor’s BEST Nattokinase Supplement is one of the best natural products that can be used to support heart and circulatory health.

Pros

  • Promotes better circulation and healthy blood flow.
  • Non-GMO and vegan ingredients.
  • Contains pure nattokinase enzyme with Vitamin K2 removed.

Cons

  • May cause dizziness if taken before a meal.
  • Not eligible for international shipping.
  • Label images may vary.

It comes from Doctor’s BEST Nattokinase Supplement that is an enzyme extracted from natto – a kind of fermented soy food historically consumed in Japanese households. It’s derived from the natto soybean fermentation and it is free from Vitamin K2 and hence it is safe to be taken by anybody who wants to promote his/her heart and circulatory health without harm.

Unfortunately, the company does not disclose the amounts of nutrients present in this product, but it has no artificial components as it is made of vegan and non-GMO constituents to be a natural supplement. Consequently, through the research done it has been seen that Nattokinase is capable of supporting regular blood circulation thereby helping to enhance the health of the heart and circulatory system. Better circulation and a healthy heart are among other benefits accorded to those who take this vegan formula.

One must remember of individual difference and if you have weak blood pressure, then this issue may arise in case you decide to take Nattokinase before meal. It is advised to have it in the evening as this can cause dizziness especially after waking up from bed.

In conclusion, for those who have an interest in a viable and natural product to support heart and circulatory health, Doctor’s BEST Nattokinase Supplement should be highly considered.

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The Clean Nutraceuticals Nattokinase Supplement is our top choice on this list for anyone seeking an all-in-one solution to their dietary needs.

Pros

  • The blend of Nattokinase, Serrapeptase, and Lumbrokinase is carefully sourced and selected for maximum effectiveness, delivering 4000 units of nanokinese per serving.
  • The supplement is fortified with a variety of nutritional ingredients, such as coq10, bromaline, calcium, sofora japonica, turmeric, Vitamin B6, Vitamin C and papaya enzyme, making it a comprehensive nutritional solution.
  • The product is made in the USA and meets the highest quality standards, ensuring that you receive a premium product that stands up to our promise of quality, integrity, and efficacy.

Cons

  • Some users may not like that the supplement contains additional ingredients beyond the enzymes, although they are beneficial for overall health.
  • It may take time to see the benefits of this supplement, and lab tests may be needed to confirm.
  • The product label may be blurry or sideways, which can be frustrating.

Using this Nattokinase supplement for several weeks and we can confidently say that the quality of our health improved vastly. The enzymes are strong and argonomic, and the supplement is enhanced by other compounds to give us a holistic product that address our nutritional needs.

It is user centric and convenient to use the packaging and can easily be incorporated into the user’s lifestyle. We would like to thank the company and the manufacturer for delivering a product that is Made in USA; Our company is keen on sourcing quality and deserving products that will not disappoint our clients in any way.

Thus, based on all the highlighted and discussed factors, it is safe to say that the Clean Nutraceuticals Nattokinase Supplement is one of the best options for a high quality, effective and trustworthy supplement.

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Best Naturals’ Nattokinase Supplement, in particular, is the best nattokinase supplement that you should purchase if you are in the market for a highly effective supplement.

Pros

  • Third-party lab tested for purity and quality
  • Vegetarian capsules with 100mg of nattokinase per capsule
  • Non-GMO and gluten-free

Cons

  • May not be suitable for those with certain dietary restrictions
  • Some users may experience side effects such as dizziness or brain fog
  • Results may vary from person to person


The fact that this product was GMO free, free from gluten content and that it was a pure product was another aspect that impressed us. Actually, the vegetarian capsules ensure it is within the reach of many different specialties. We also noticed high quantity of nattokinase per capsule inclusive of regular dosages to enhance on the effectiveness of the product.

However, there are contradictions to these findings small side effects such as dizziness and brain fog might be experienced in some users and it is not suitable for users with special diet. Further, the efficacy of the treatment is likely to be different in different patients, which produces varied outcomes.

In conclusion, we think that the purchasers should consider their options and conclude that the Best Naturals Nattokinase Supplement may be a good addition to their daily dietary supplements.

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As a naturally sourced supplement used to encourage optimal cardiovascular and blood circulation, Yasumako Lumbrokinase Supplement should do the trick.

Pros

  • The powerful 3-in-1 potency formula with lumbrokinase, nattokinase, and red yeast rice provides comprehensive support for cardiovascular and blood circulation health.
  • The pure ingredients and optimal absorption make it easy to incorporate into your daily routine.
  • The quality and satisfaction guarantee from Yasumako offer peace of mind for your purchase.

Cons

  • The price may be higher than other supplements on the market.
  • It may take some time to see noticeable results.
  • It may not be suitable for those with certain medical conditions or taking certain medications.

Using yasumako Lumbrokinase Supplement for these past few weeks have tremendously helped in the enhancement of blood circulation and over all cardiovascular systems. Lumbrokinase together with nattokinase and red yeast rice are all synergistic in their effects forming a regimen that is simply and effectively adaptable into our busy lifestyles. It is easy to swallow the capsules and there is no adulteration from ice creams implying that the ingredients are pure hence easily absorbed by the body.

This may be comparatively expensive than other supplements each of the market but we stated earlier that the quality and effectiveness of this supplement makes it worth all the shots. results may not be as soon as you expected, however, we firmly believe in this product’s effectiveness. Nevertheless, one must understand that this supplement may not be beneficial for every person and more so for those who are undergoing some medical treatments or have other health complications.

All in all, Yasumako Lumbrokinase Supplement is a great solution for those interested in enhancing blood circulation and overall cardiovascular health through natural supplements.

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The Complete Natural Products Nattokinase Capsules can be recommended to any individual who needs a natural supplement for circulation and general health treatment.

Pros

  • Made from pure Natto Enzymes with no fillers
  • Clinically researched to help support healthy circulation
  • Natural and non-GMO, vegan and gluten-free

Cons

  • May thin the blood a bit
  • Label does not appear to have a GMP stamp or 3rd party la
  • Price/value is okay

By using the Complete Natural Products Nattokinase Capsules, we discovered that they work effectively for circulation support as well as overall health treatment. It is said that the capsules are free from any additives or fillers and that it contains all natural Natto Enzymes that have been examined in scientific studies. Also, it lacks any meat or dairy derivatives and has no gluten which makes it suitable for people who have special dietary requirements requiring natural products.

However, one should be informed that, in fact, the product may tend to slightly thicken the blood, and thus, it is crucial to note this side effect. Further, there is no impressed statement from GMP or 3rd party laboratory; and the strategically position price/value is fair.

In conclusion, we recommend the Complete Natural Products Nattokinase Capsules for individuals who desire the natural supplements to assist in the overall health treatments as well as healthy circulation.

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To get a sound and efficacious nattokinase supplement, we must suggest using the NusaPure Nattokinase supplement.

Pros

  • Provides 800mg and 4000 FU per serving, making it a highly potent supplement.
  • Vegan/Vegetarian, NON-GMO and Gluten Free, making it a great option for those with dietary restrictions.
  • Manufactured in the USA in a cGMP registered facility with high standards, ensuring quality and safety.

Cons

  • May not be suitable for those with blood clotting disorders without consulting a healthcare provider.
  • Some users may experience mild side effects such as headache or stomach discomfort.
  • May not be suitable for those taking blood thinning medications.

Lastly, we noted they it was easy to include the NusaPure Nattokinase supplement in our diet and that we observed improvements. This potency was much higher compared to those other nattokinase supplements which we have used earlier and that is why it was so effective. It was vegan vegetarian, NON-GMO and gluten-free which made it more appealing to anyone who has tight restrictions on what they allow themselves to eat. Further, they are manufactured in the cGMP-registered facility with stringent standards hence we felt certain about the quality and safety of the product.

The supplement is useful, but it is advisable to consult the doctor before using it if you are suffering from blood clotting disorders or if you are on blood thinning medications. One should carefully evaluate all possible side effects of the product, which, nevertheless, some users may encounter, like headache or upset stomach If any, we did not observe them personally. In conclusion, we feel that the NusaPure Nattokinase supplement is in fact one of the most effective nattokinase supplements out there.

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These enzymes assist in maintaining cardiovascular needs and blood circulation and thus, SOLARAY Nattokinase and Serrapeptase Supplement 30 Count could also be the best choice for you.

Pros

  • Supports healthy cardiovascular function
  • Helps to improve blood flow
  • Contains serrapeptase for extra support

Cons

  • Capsules may be difficult to swallow for some people
  • May not be suitable for those with bleeding disorders
  • Some users reported that the bottle did not contain the promised 30 pills


For the past few weeks now, we have been incorporating the SOLARAY Nattokinase and Serrapeptase Supplement 30 Count in our daily diets, and the results are amazing concerning the flow of blood in our bodies. The capsules are small and in a few cases are easy to swallow because they have that enteric coating to ensure that the formula gets to the small intestines without being damaged by stomach acids.

Together nattokinase and serrapeptase is quite powerful and we think this supplement does wonders for the health of our cars, our cardiovascular system. We also consider the reliability of SOLARAY as a company as well as the fact that the product is their own manufacturing, which has been tested in the lab for effectiveness and free from impurities.

Nevertheless, we would like to mention the fact that several users mention that the bottle, actually contains less than 30 pills. Also, some people may find it challenging to swallow the capsules which may result in a choking hazard. Also, for those with bleeding disorders, it is advisable to seek the advice of a doctor when using this supplement.

In conclusion, we highly believe that every candidate who is eager to boost his/her cardiovascular health and circulation should give SOLARAY Nattokinase and Serrapeptase Supplement 30 Count a shot.

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In essence if you need a natural supplement that plays a role in heart and circulatory health, then you should consider PHARMAKON Nattokinase.

Pros

  • Organic fermented soybean extract
  • Contains up to 300 types of health-promoting active compounds
  • Money-back guarantee

Cons

  • Only 90 capsules instead of advertised 120
  • No organic certification listed
  • May cause gas, bloating, and diarrhea in some individuals

PHARMAKON Nattokinase has been on our diet for some weeks now and ever since we took it, there has been tremendous enhancement in our health conditions. This Nutrients supplement is derived from fermented soy beans; it has not undergone rigorous processing so as to retain a harmonious blend of all the natural products in the extract, thus making it as natural-food supplement that can be taken in the morning without much he, being a food supplement it fits easily into our daily diet.

Yet there is no doubt that PHARMAKON Nattokinase can contain up to 300 types of health-promoting active compounds where Nattokinase of clearly the most potent. Due to its ability to improve circulation and maintain healthy blood vessels it is ideal for any one who would like to maintain his or her circulatory system without necessarily having to use drugs.

We also would like to note that the company provides a money guaranty, which is always helpful when choosing a service to cooperate with. Just in case we aren’t happy with what we have ordered we can be certain to be fully refunds our money.

That being said we did see a couple of peculiarities about this product which we will outline as follows: Firstly, there are only 90 capsules in this pack while the manufacturer boasts of 120, secondly it is expensive compared to other brands that offer almost the same product. Also, there is no word concerning the organic certification, therefore we are not completely convinced that it is actually organic. Lastly, there are some people who develop symptoms such as gas, bloating of the stomach and diarrhea as a result of consuming this supplement.

In conclusion, we would like to recommend PHARMAKON Nattokinase to anyone who is interested in purchasing a natural product that acts as a supplement to maintain healthy heart and blood vessels. It is therefore crucial to be aware of the possible risks associated with purchasing an iPad before going out to buy one.

Buying Guide

In evaluating the best nattokinase supplement there are some factors to consider. Here are some features to look for:

1. Potency

It is also important to note that the effectiveness of commercial nattokinase preparations may differ depending on the dosage they contain. Search for a formula with a high concentration, preferably with a 2000 FU (fibrinolytic units) per capsule. This will also help flush the bloodstream with effective nattokinase dose, ensuring its safety and efficacy.

2. Purity

Ensure you are not linking the supplement to added preservatives and other unhealthy ingredients. Ensure that the product contains natural and untamed raw materials at their best quality.

3. Dosage

Consult with the label on this product to ensure that the doctor advanced a proper dosage. It is evident that some of the product may may call for more than one capsule daily intake while others may warrant only a single capsule intake per day. Just ensure that the particular product you have settled to use is one that you prefer and or is compatible with your lifestyle.

4. Price

Price of Nattokinase supplements may differ from country to country or even within the country depending on purity. To summarize, look for a product that you can afford but then again do not just settle for anything that is cheap.

5. Brand Reputation

Finally, check out the brand of the supplement and its compatibility with your goals. It is best to get your service from a reputable company that is known for the high quality of service it offers to its clients. Customers should look at the descriptions of other customers in order to learn about the efficiency of the product.

6. Third-Party Testing

Purity and potency stand out as two of the most salient attributes you will come across; ensure that the product has been tested for these two by a third party. This is because you will be in a position to determine that you are getting the right quality product with no negative component to it.

Hence, you will be in a position to select the appropriate nattokinase supplements for use after meeting the following factors.

Frequently Asked Questions

1. Is nattokinase effective in clearing arteries?

Nattokinase also has been proven to be an anticoagulant, which working to help expand blood vessels and prevent formation of blockage causing blood clot, thus improving circulation. While it may have other medical uses, there is scant evidence to suggest that it effectively dissolves blood clots and clears blockages. However, more research and clinical trials are required to analyze the kind of value that it has, in this particular field.

2. What is the recommended dosage for nattokinase supplements?

Some brands and formulations of nattokinase supplements may be dosed differently from others and therefore, it is advisable to consult the instructions of the specific brand tha Another precaution that can be taken is paying attention to what the manufacturer has stated, and to consult a docotor before using the supplement.

3. What is the best time of day to take nattokinase supplements?

There are no contraindications to the use of nattokinase supplements, and their action does not depend on the time of day. While some people have it for breakfast, others may have it in the evening or before going to bed. Reliability changes depend on the dosing time during the day, and it is crucial to maintain an approximate schedule.

4. How do I choose the best nattokinase supplement?

If one would opt to take a nattokinase supplement, then they must be very careful in choosing a good brand that comes with a good quality of nattokinase. Choose products that contain information on the third party testing of the purity and potency of the person. Another factor that should not be overlooked is the quantity, and format of the supplement coupled with Medical history and drug Interactions.

5. Is nattokinase worth taking for kidney health?

Specifically, available literature on the use of nattokinase for improving kidney functions is scarce in the current literature. However, lithium orotate has demonstrated positive effects in some studies, but to fully check its impact more research has to be carried out. Due to this, it would be advisable to talk to a doctor of one’s choice before undertaking any course of supplement intake especially if one has kidney disorders or any other disease.

6. Where can I find the best deals on nattokinase supplements?

Combining the benefits of nattokinase and serrapeptase in the form of supplements is widely available at health stores, online shops, and through health care professionals. Though it may seem obvious, the recommendation is to always check price and reviews of the product that one wants to buy. There are cases where specific retailers will make offers that allow buying the product at a cheaper price per unit for a large quantity, or subscribe to the product and pay less per use.

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The stories shared below are not written by Buoy employees. Buoy does not endorse any of the information in these stories. Whenever you have questions or concerns about a medical condition, you should always contact your doctor or a healthcare provider.
Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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