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Top 10 Best Omega-3 Supplements for Heart Health

Best Omega-3 Supplements for Heart Health
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Written by Andrew Le, MD.
Medically reviewed by
Last updated July 30, 2024

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Omega-3 fatty acids are essential for heart health, yet modern diets often lack these important nutrients, leaving many vulnerable to cardiovascular diseases. These deficiencies can contribute to inflammation and the buildup of arterial plaques.

Omega-3 supplements, available as fish oil, krill oil, and plant-based options, help manage cholesterol levels and improve the elasticity of blood vessels. This subsequently enhances cardiovascular circulation and overall heart health.

Below we have evaluated the best Omega-3 supplements, including information on the various forms and essential types of omega-3 fatty acids your body needs. This article will help guide you through selecting a supplement that aligns best with your lifestyle and dietary preferences.

General Benefits of Omega-3 Supplements for Heart Health

Omega-3 fatty acids are renowned for their remarkable ability to promote heart health. These essential nutrients primarily help reduce systemic inflammation.

Additionally, Omega-3s effectively manage cholesterol levels by increasing high-density lipoprotein (HDL) and reducing triglycerides, thereby preventing the formation of arterial plaques, which are linked to heart attacks and strokes.

Research supports that Omega-3 supplements improve arterial health by enhancing the elasticity of blood vessel walls, which helps maintain healthy blood pressure and circulation​.

Research indicates that omega-3 PUFA improves arterial hemodynamics by reducing arterial stiffness, thereby enhancing cardioprotective properties. Additionally, they positively impact endothelial activation, likely leading to better vascular function. The molecular, cellular, and physiological pathways influenced by omega-3 PUFA contribute to changes in arterial wall properties, potentially interfering with the atherosclerotic process. Despite some uncertainties about the mechanisms and optimal doses, omega-3 PUFA shows promise in improving arterial wall remodeling and cardiovascular outcomes by addressing arterial wall stiffening and endothelial dysfunction.

Further supporting their cardiovascular benefits, another study discussed that omega-3 PUFA enhances endothelial function and promotes vasodilatation by relaxing smooth muscle cells. They also exert antioxidant, anti-inflammatory, and antithrombotic effects, delay plaque development, increase plaque stability, and reduce arterial wall stiffening. While initial results from secondary prevention trials were encouraging, meta-analyses have not confirmed omega-3 PUFA's ability to reduce the risk of coronary heart and cerebrovascular disease. Therefore, further investigation is needed to strengthen the evidence supporting the role of omega-3 PUFA in cardiovascular prevention.

Types of Omega-3 Supplements

Omega-3 supplements come in various forms, primarily from fish, krill, and plant-based alternatives. Each type offers distinct benefits and sources of EPA and DHA, the two crucial types of omega-3 fatty acids:

  • Fish Oil: primarily sourced from fatty fish like mackerel, salmon, and sardines, is rich in EPA and DHA which are the two types of omega-3 fatty acids. It's well-known for its heart-healthy benefits, particularly in supporting cardiovascular health, including reducing triglycerides and improving heart health​​.
  • Krill Oil: Sourced from Antarctic krill, this oil is known for its high absorbability and lower risk of fishy aftertaste. Krill oil contains not only EPA and DHA but also phospholipids and astaxanthin, which provide additional antioxidant benefits​.
  • Plant-Based Omega-3s: Supplements derived from algae or flaxseed are available for those who prefer a vegetarian or vegan option. These usually contain ALA (alpha-linolenic acid), which the body can convert to EPA and DHA at a low rate but are still beneficial for heart health​​.

Considerations When Choosing Omega-3 Supplements

When selecting omega-3 supplements, several vital considerations should guide your choice to ensure safety, efficacy, and suitability to your health needs:

  • Quality and Purity: Choose the best omega-3 supplements that have been through third-party testing to confirm their purity and potency. Reliable organizations such as NSF International, US Pharmacopeia, and ConsumerLab offer certifications that indicate a product has been tested rigorously for contaminants like heavy metals and their nutritional content​.
  • EPA and DHA Content: Omega-3 supplements should primarily contain EPA and DHA, the most beneficial omega-3 fatty acids. Check the label for high concentrations of these, as they are crucial for cardiovascular health, reducing inflammation, and supporting brain function​.
  • Dosage: The recommended daily intake of omega-3 varies, generally between 250-2000 mg of EPA and DHA, depending on health needs. Consult a healthcare provider for personalized advice.
  • Source and Sustainability: Opt for omega-3 supplements made from effective and sustainable sources. Fish oil should ideally come from small, oily fish like sardines or anchovies, which are less likely to be contaminated with mercury. Algal oil is a direct source of DHA and a sustainable choice​​ for plant-based options.
  • Potential Interactions and Side Effects: Be conscious of possible drug interactions, particularly blood thinners, as omega-3 has blood-thinning properties. Some people may also experience mild gastrointestinal issues or a fishy aftertaste with fish oil supplements. High-quality, molecularly distilled fish oil or refrigeration of supplements can help minimize these effects​​.
  • Consult with a Healthcare Professional: If you have health conditions or are taking other medications, it's recommended to seek advice with a healthcare professional prior to beginning a regimen of omega-3 supplements. This can help avoid adverse interactions and ensure the supplement supports your overall health goals​.

Top 10 Best Omega-3 Supplements

When selecting the best Omega-3 supplements for heart health, it's essential to understand the significant impact these nutrients have on reducing inflammation and supporting cardiovascular health.

As you explore the diverse range of Omega-3 products, consider the factors such as the source of the omega-3s, the purity of the product, the balance and dosage of EPA and DHA, and third-party testing. Here's a closer look at some of the best Omega-3 supplements for your heart health:

OmegaWell Fish Oil

OmegaWell Fish Oil by Live Conscious is designed to enhance heart, brain, joints through its high-strength formula containing 800 mg of EPA and 600 mg of DHA. Priced at $26.70 for a 30-day supply, each soft gel capsule delivers these potent omega-3 fatty acids in an easy-to-swallow format.

The product is known for its natural lemon flavor, which helps mitigate the typical fishy aftertaste associated with omega-3 supplements. The fish oil is sustainably sourced, and the capsules are enteric-coated, which assists in better absorption and prevents the fishy burps usually expected from fish oil consumption.

Pros

  • It contains high levels of DHA and EPA, known for cardiovascular, cognitive, and joint health, which makes it the best omega-3 supplements for rheumatoid arthritis.
  • Enteric-coated soft gels enhance absorption and reduce the likelihood of experiencing a fishy aftertaste or burps.
  • The use of natural lemon flavor makes the capsules more palatable.
  • Sustainably sourced, appealing to environmentally conscious consumers.
  • The product is free from common allergens such as soy, dairy, gluten, peanuts, and shellfish, making it suitable for individuals with allergies.

Cons

  • The cost per count ($0.45 per soft gel) is slightly higher than some competitors offering larger quantities or lower prices.
  • Packaged as a 30-day supply, frequent reordering is necessary, which might be inconvenient for some users.
  • Some customers may still experience mild digestive discomfort despite the enteric coating.
  • It is only available in soft gel form, which might not be preferred by those who have difficulty swallowing pills.
Calgee Vegan Omega-3

Calgee Vegan Omega-3 offers a plant-based alternative to traditional fish oil supplements, delivering 450mg of DHA and EPA per serving from algae oil. This product is designed to support cognitive health, immunity, and cardiovascular health.

Each soft gel is formulated to be free from major allergens and does not contain carrageenan, enhancing its appeal to those with dietary sensitivities. The Omega-3 supplement is sustainably sourced, ensuring minimal environmental impact, and is packaged in an eco-friendly pouch.

Priced at $27 for a 60-count supply or $0.50 per soft gel, Calgee provides an ethical and health-conscious option for supplementing these crucial nutrients.

Pros

  • Calgee Vegan Omega-3 is derived from algae, providing a sustainable and fish-free source of essential fatty acids.
  • The product supports brain health, cardiovascular health, and immune system function.
  • It is free from gluten, corn, soy, and shellfish, making it suitable for individuals with these common allergies.
  • The soft gels do not have a fishy aftertaste, which is a frequent concern with fish oil-based omega-3 supplements.
  • The algae oil used in Calgee Vegan Omega-3 is among the richest plant-based sources of Omega-3 available, providing a potent dose of EPA and DHA.

Cons

  • Some users may find the cost of $0.50 per soft gel higher than some non-vegan alternatives that offer similar omega-3 benefits.
  • The packaging, while eco-friendly, may provide a different level of protection and longevity than traditional plastic or glass bottles.
  • A few users report issues with the pill size or taste, although these are minor and not widespread concerns.
  • As a specialized vegan product, it may not be as widely available in all regions or stores, potentially limiting accessibility for some consumers.
Dutch Harbor Omega 3 Fish Oil

Dutch Harbor Omega 3 Fish Oil is a supplement sourced from wild Alaskan cod liver. It's famous for its high levels of omega-3 fatty acids, including EPA, DHA, and DPA. Priced at $54 for 120 soft gels, each capsule is infused with a pleasant lemon flavor to enhance the user experience.

This product is sourced responsibly from the Bering Sea, utilizing sustainable, line-caught fishing methods to ensure environmental preservation. The fish oil is processed using innovative techniques that retain the natural vitamins A and D, crucial for vision, immune function, bone strength, and overall health.

Pros

  • The fish oil is extracted from line-caught Alaskan cod, ensuring high-quality and sustainable sourcing.
  • It contains essential Omega-3 fatty acids like EPA, DHA, and DPA, which benefit heart health, cognitive function, and cellular health.
  • Includes natural forms of vitamins A and D, supporting vision, immune function, and bone health.
  • Innovative processing retains the effectiveness of natural vitamins, often lost in standard extractions.
  • Lemon-flavored soft gels make consumption more enjoyable and help to minimize fishy aftertaste.

Cons

  • Higher price points than some other fish oil supplements might concern budget-conscious consumers.
  • The soft gels may be large for some users, potentially making them difficult to swallow.
  • Although rare, some users might experience digestive discomfort or fishy burps despite the flavoring and coating efforts.
  • The specific benefits of vitamins A and D in the context of fish oil supplementation might not be as significant as those derived directly through diet or standalone supplements.
Perricone MD Omega 3 Supplements

Perricone MD Omega 3 Supplements offer a long-term, 90-day supply of omega-3 fatty acids derived from wild sockeye salmon. These supplements support cardiovascular health, hydrate skin from the inside out, and improve overall wellness.

Marketed at $115.00 for a 90-day supply, these soft gels are made in the USA and exceed both U.S. and international standards for potency and purity of omega-3 supplements. The product leverages the health benefits of DMAE and omega-3 fatty acids to aid in mood elevation, weight management, and enhancing skin health, making it an integral part of a balanced diet and a healthy lifestyle.

Pros

  • Sourced from wild Alaskan salmon oil, ensuring a high-quality and sustainable source of omega-3.
  • It supports cardiovascular health and hydrates the skin, promoting a healthy heart and improved skin condition.
  • It is free from wheat, soy, synthetic colors, flavors, dyes, and sugar substitutes, making it suitable for individuals with specific dietary restrictions.
  • The product is made in the USA and meets rigorous potency and purity standards.
  • Offers additional health benefits such as mood elevation and support in weight management.

Cons

  • The price point of $115 for a 90-day supply may be considered high for some consumers.
  • The large pill size could be difficult for some users to swallow.
  • Like many fish oil products, there is a potential for fishy aftertaste or burps despite quality processing.
  • Limited flavor options are available only in the standard formulation without alternative flavors.
  • The benefits of DMAE in omega-3 supplements are less widely recognized and understood, which might cause hesitation for some potential users.
Nordic Naturals Ultimate Omega

Nordic Naturals Ultimate Omega offers a high-potency omega-3 fish oil supplement in a convenient soft gel form. Each serving contains 1280 mg of omega-3s, including EPA and DHA, essential nutrients for maintaining a healthy heart and brain function.

Priced at $31.49 for a 90-count bottle, these lemon-flavored soft gels are designed to support overall health without the fishy aftertaste typical in other fish oil products. Nordic Naturals prides itself on its commitment to delivering pure and fresh omega-3 oils derived from 100% wild-caught fish, making it a leader in the omega-3 supplement market.

Pros

  • A high concentration of EPA and DHA helps support cardiovascular health and cognitive function.
  • Sourced from wild-caught fish, ensuring sustainability and environmental responsibility.
  • Lemon flavoring helps mask the fishy taste typical of omega-3 supplements.
  • Free from gluten and dairy, catering to those with specific dietary restrictions.
  • Manufactured according to rigorous quality control standards, guaranteeing both purity and potency.

Cons

  • Higher price point compared to some other omega-3 supplements available on the market.
  • Some users may still experience a mild fishy aftertaste despite the lemon flavor.
  • The soft gels are relatively large, which might be difficult for some people to swallow.
  • Frequent users might need more than the 90-count bottle for long-term use, necessitating frequent purchases.
  • It is only available in soft gel form, which might not suit those who prefer liquid or gummy alternatives.
Viva Naturals Omega 3 Fish Oil

Viva Naturals Omega 3 Fish Oil Supplement stands out in the market with its high-potency formula that delivers 2500 mg of fish oil, including significant amounts of EPA (1500 mg), DHA (568 mg), and DPA (50 mg) per serving. This formulation supports heart, brain, skin, and eye health.

The fish oil comes from wild-caught fish such as sardines, anchovies, and mackerel. It undergoes purification to decrease contaminants like mercury and PCBs. Offered at $49.46 for a pack of 180 soft gels, it provides a three-month supply, assuming the recommended daily intake.

Pros

  • The high dosage of EPA and DHA per serving effectively supports cardiovascular and cognitive health.
  • Viva Naturals uses fish oil in the re-esterified triglyceride form, which enhances the body's absorption of omega-3s.
  • The product is purified to remove heavy metals and other potential contaminants, ensuring safety and purity.
  • Certified by IFOS, verifying the quality, concentration, and purity of the fish oil.
  • The soft gels are unflavored, which minimizes any unpleasant fishy aftertaste and makes them easier to consume.

Cons

  • Some users may find the soft gels large and difficult to swallow due to their size.
  • Although the product is unflavored, a few users might still experience residual fishy burps or aftertaste.
  • The higher concentration and triple-strength formulation make this product more expensive than other omega-3 supplements.
  • As with any high-dose fish oil product, there is a potential for minor gastrointestinal side effects in sensitive individuals.
  • While the product boasts high purity and sustainability, the packaging does not specify the exact method of fish oil extraction, which may concern environmentally conscious consumers.
Carlson Fish Oil, 700 mg Omega-3s

Carlson Fish Oil offers potent omega-3 fatty acids that promote heart, brain, vision, and joint health. Each serving contains 700 mg of omega-3s and is crafted from the highest quality, deep, cold-water fish using sustainable methods. This ensures that the fish oil remains fresh from the sea and stored.

Packaged in soft gels with a pleasant orange flavor, this supplement makes daily omega-3 intake enjoyable without the typical fishy aftertaste. The product is available in a 120 soft gel bottle priced at $28.48, making it $0.24 per count. It is also certified by IFOS and IGEN as non-GMO, guaranteeing that it maintains a high standard of purity and potency.

Pros

  • Carlson uses sustainably sourced fish, ensuring environmental responsibility.
  • Each soft gel contains a robust 700 mg of omega-3s, effectively supporting cardiovascular and cognitive health.
  • The orange flavor masks any fishy taste, making the soft gels easy to take without an unpleasant aftertaste.
  • The product is rigorously tested for freshness, potency, and purity and is free from detectable levels of mercury and other contaminants.
  • The soft gels are gluten-free, catering to those with specific dietary needs.

Cons

  • The soft gels might be large for some, potentially making them difficult to swallow.
  • Despite the flavoring, some users may still experience mild fishy burps, which is a common issue with fish oil supplements.
  • The non-returnable policy on this dietary supplement might dissuade first-time buyers from trying the product.
  • Some users might find the cost per bottle slightly higher than other omega-3 supplements on the market.
  • The packaging needs to provide detailed information about the extraction process of fish oil, which might concern users who are interested in the specifics of manufacturing practices.
Barlean's Ideal Omega 3 Fish Oil Supplement

Barlean's Ideal Omega 3 Fish Oil provides a dose of omega-3 fatty acids for maintaining heart, brain, joint, and immune health. Each soft gel delivers 1000mg of fish oil, including 750mg of EPA and 250mg of DHA, sourced from wild-caught pollock. This makes the product the best omega-3 supplements for rheumatoid arthritis.

This pharmaceutical-grade supplement is designed for optimal absorption and efficacy, with a single soft gel providing the necessary nutrients without requiring multiple doses. The product is also IFOS-certified, ensuring purity and sustainability.

The orange-flavored soft gels make consumption a pleasant experience, free from the fishy aftertaste commonly associated with fish oil supplements. Priced at $35.99 for a 60-count bottle or $0.67 per soft gel, it offers a practical option for daily supplementation.

Pros

  • Barlean's fish oil is highly potent, providing 1000mg of omega-3s in a single soft gel, making it convenient for users with a high intake requirement.
  • The supplement supports various aspects of health, including cognitive function, heart health, and inflammatory response, making it versatile.
  • It holds a 5-star rating from IFOS for purity and freshness, ensuring a high-quality product free from harmful contaminants.
  • The orange flavor effectively masks the fishy taste, enhancing user compliance with daily intake.
  • Barlean's is a well-established brand with over 30 years in the dietary supplement industry, reflecting reliability and trustworthiness.

Cons

  • Some users may find the soft gels large and difficult to swallow.
  • Despite the flavoring, occasional fish burps may still occur, which could be off-putting for some users.
  • The cost per bottle might be considered high compared to other omega-3 supplements available on the market.
  • Being a high-potency supplement,
  • It might not be suitable for everyone, particularly individuals who need a lower dosage of omega-3.
  • The non-returnable policy could deter potential buyers who are cautious about trying new supplements.
Life Extension Super Omega-3 EPA/DHA Fish Oil

Life Extension Super Omega-3 EPA/DHA Fish Oil, priced at $26.37, is a high-quality nutritional supplement that combines the heart health benefits of fish oil with the antioxidant support of sesame lignans and olive extract. This potent formula supports cardiovascular health, cognitive function, and an anti-inflammatory response.

Each bottle contains 240 easy-to-swallow soft gels, offering a substantial gluten-free and non-GMO supply. Including Polyphen-Oil Olive extract and sesame seed, lignan extract adds a unique twist, enhancing the supplement's effectiveness in managing inflammation and supporting overall health.

Pros

  • The supplement offers a high concentration of EPA and DHA, providing more omega-3s in fewer soft gels, which simplifies dosage.
  • It supports various health benefits, including cardiovascular health, brain function, and anti-inflammatory responses, making it versatile for multiple health needs.
  • The product is IFOS certified, ensuring it meets high standards for purity and potency and is free from harmful levels of contaminants.
  • Life Extension is a reputable brand with extensive experience, enhancing user trust in the supplement's quality and efficacy.
  • The soft gels are convenient to take and are formulated to minimize fishy aftertastes and burps, improving user compliance.

Cons

  • Some users may find the soft gels too large, which can be a challenge for those with difficulty swallowing pills.
  • There have been occasional reports of the product having a fishy smell, which might be off-putting for some users despite the quality of the oil inside.
  • The cost per bottle might be considered high compared to other omega-3 supplements, although the quality and dosage may justify the price.
  • The product's comprehensive benefits might lead to high expectations that are not always met, depending on individual health conditions and body responses.
Sports Research Antarctic Krill Oil Omega 3

Sports Research Antarctic Krill Oil Omega 3 Soft gels, priced at $27.86, offer a high-quality omega-3 supplement from sustainably harvested Antarctic waters.

Each soft gel delivers a potent 1000mg dose of Pure Antarctic Krill Oil, which contains higher concentrations of omega-3 fatty acids (EPA & DHA), Choline, Phospholipids, and Astaxanthin than other brands on the market. The krill used in this product is fully traceable from sea to bottle, ensuring both sustainability and premium quality.

Pros

  • Contains a high concentration of omega-3, beneficial for heart, brain, and joint health.
  • Superior absorption due to phospholipid-bound omega-3s, which integrate well with the body's cells.
  • No fishy aftertaste, a common issue with fish oil supplements, thanks to the phospholipid form of omega-3s.
  • Certified sustainable by the MSC, non-GMO verified, and gluten-free that caters to various dietary needs and preferences.
  • Made in a cGMP-compliant facility in the USA, ensuring high manufacturing standards.

Cons

  • Krill oil products can cause digestive discomfort if taken without meals or in high doses.
  • Allergic reactions are possible for those sensitive to shellfish, as the product contains krill.
  • Some users may find the capsules large or difficult to swallow.

Wrapping Up

The advantages of omega-3 fatty acids for heart health are well-documented, making supplements a valuable addition to many diets.

Among the top products, OmegaWell Fish Oil stands out with its high-strength formula and natural lemon flavor, offering significant cardiovascular benefits in an easily absorbable form.

For those preferring a plant-based option, Calgee Vegan Omega-3 provides a high-quality algae alternative, ensuring health and environmental sustainability.

Both products exemplify the effectiveness and safety needed for enhancing heart health through omega-3 supplementation.

FAQs on the Best Omega 3 Supplements

What are the differences between fish oil and krill oil supplements?

Fish oil is the most common source of omega-3s and contains high levels of both EPA and DHA. Krill oil, on the other hand, is known for its potentially higher absorbability and lower risk of fishy aftertaste because the omega-3s in krill oil are bound to phospholipids, enhancing their easy absorption.

What are the benefits of the best omega-3 supplements?

The best omega-3 supplements are known for supporting improving brain function, cardiovascular health, and reducing inflammation. High-quality omega-3 supplements can also help maintain healthy skin and joint mobility.

Are there any side effects associated with the best omega-3 supplements?

While the best omega-3 supplements are safe for most people, they can cause minor side effects such as fishy aftertaste, gastrointestinal discomfort, or mild allergic reactions, mainly if you are sensitive to fish or shellfish.

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Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
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