Skip to main content
Read about

GABA (Gamma-Aminobutyric Acid) Supplements for Anxiety

Best GABA (Gamma-Aminobutyric Acid) Supplements
Tooltip Icon.
Written by Andrew Le, MD.
Medically reviewed by
Last updated September 19, 2024

Try our free symptom checker

Get a thorough self-assessment before your visit to the doctor.

Anxiety is a pervasive problem that impacted 301 million people in 2019, disrupting daily life and causing significant distress. The constant worrying and physical symptoms like increased heart rate and muscle tension can be overwhelming and debilitating.

Conventional treatments for anxiety, such as prescription medications, can come with undesirable outcomes and the risk of developing dependencies, leaving many individuals seeking alternative, natural solutions.

Fortunately, there is a growing body of research supporting the use of the best GABA supplements as a safe and effective way to mitigate anxiety symptoms. By boosting levels of this crucial inhibitory neurotransmitter, GABA supplements can help promote relaxation, reduce nervous tension, and support a calm, balanced state of mind.

The best GABA supplements have been carefully selected for their quality ingredients, potency, and proven efficacy in providing natural anxiety relief.

Benefits of GABA Supplements

GABA is primarily known for its calming effect on the nervous system, making it a crucial component in managing anxiety and stress levels. GABA supplements are widely used to enhance this natural calming process, providing relief from anxiety, helping to promote relaxation, and enhancing the quality of sleep.

Research indicates that GABA supplements may significantly aid in relaxation and reduce symptoms of anxiety. Studies have shown that GABA (γ-aminobutyric acid) supplements can offer several potential benefits, particularly for mood disorders and anxiety. Research indicates that individuals with major depressive disorders (MDDs) often have reduced levels of GABA in the brain and alterations in the GABAA receptors, which play a crucial role in mediating GABAergic inhibition. GABA is also involved in stress regulation, a key factor in mood disorders. Although evidence supporting the direct action of orally ingested GABA within the brain is limited, emerging research suggests that GABA may benefit the brain and psyche through the gut-brain axis. GABA supplements are popular in Eastern Asia, with many users reporting improvements in stress regulation, mood, and sleep. However, rigorous independent research is still needed to understand its effects fully.

Safety and Side Effects

While GABA supplements are generally considered safe for most people, it is essential to be aware of potential side effects and interactions with other medications.

Common side effects of GABA supplementation can include:

These effects typically occur when supplements are taken in higher than recommended doses or on an empty stomach.

A comprehensive safety review concluded that GABA supplements are well-tolerated by most individuals, with minimal adverse effects reported across numerous studies. The review also emphasizes the significance of following recommended doses to prevent potential adverse effects, emphasizing the necessity of expert advice when utilizing GABA supplements, particularly for individuals with existing health issues or those on other medications.

Best GABA Supplement for Anxiety Relief

We have thoroughly researched and curated a list of the best supplements for GABA, the neurotransmitter crucial for anxiety relief. Selected based on effectiveness, ingredient quality, and user feedback, these supplements excel in promoting relaxation and alleviating nervous tension, offering a natural approach to anxiety relief.

Nutricost Pure GABA

Nutricost Pure GABA 500G Powder offers a potent solution for individuals seeking relief from anxiety. With its pure GABA formulation, this supplement aims to support relaxation and improve sleep quality. Each scoop provides 500mg of GABA, making it easy to customize dosage according to individual needs. Manufactured in a GMP-compliant, FDA-registered facility, Nutricost ensures quality and purity in every bottle.

Pros

  • Nutricost Pure GABA Powder contains no additional ingredients, offering a straightforward and effective solution for anxiety relief.
  • With a scoop included, users can easily adjust their dosage to suit their individual needs, allowing for flexibility in supplementation.
  • Nutricost Pure GABA Powder is formulated without gluten or GMOs, making it suitable for various dietary preferences and restrictions.
  • Manufactured in a GMP-compliant facility and registered with the FDA, Nutricost prioritizes quality and purity in every batch of GABA powder.
  • At $21.95 for a 500-gram bottle, Nutricost Pure GABA Powder offers excellent value for money compared to other anxiety relief supplements on the market.

Cons

  • Some users may find the taste of GABA powder slightly mineral-y, although it is generally considered tasteless when mixed with water.
  • While many users report positive effects on anxiety and sleep, individual responses to GABA supplementation may vary, and some may not experience the desired effects.
  • A few users have noted that the powder does not fully dissolve in water, which could affect the overall consumption experience.
  • Although rare, some individuals may experience side effects such as Central Sleep Apnea or discomfort, as reported by a few users.
Double Wood Supplements GABA

This GABA supplement by Double Wood Supplements stands out as the best option for individuals seeking anxiety relief and improved sleep quality. With each serving providing 1,000mg of GABA, this product supports calmness, relaxation, and healthy sleep habits. GABA, an inhibitory neurotransmitter, is crucial in promoting relaxation and aiding in sleep regulation.

Pros

  • Each capsule contains 1,000mg of GABA, ensuring a potent dose for effective support.
  • With 300 capsules per bottle, it offers a 150-day supply, providing long-term support for sleep and relaxation.
  • Encapsulated and tested for potency and safety in the USA, this supplement meets rigorous quality standards.
  • Vegan-safe, gluten-free, and non-GMO formulation caters to various dietary preferences and restrictions.

Cons

  • Some users may not experience immediate or consistent results in sleep improvement.
  • Users seeking higher GABA doses may require multiple capsules per serving, potentially increasing the overall cost.
  • Being in capsule form, individuals who prefer liquid or powdered supplements may find it less appealing.
OLLY Ultra Strength

OLLY Ultra Strength Goodbye Stress Softgels are a potent solution for those seeking relief from anxiety and stress. These soft gels are expertly formulated with powerful botanicals and nutrients to promote a calm and centered mind.

At the heart of this stress-relief supplement is GABA, paired with L-Theanine, which functions synergistically with GABA to enhance feelings of tranquility and Lemon Balm. These soft gels offer comprehensive stress relief. Additionally, Ashwagandha is included in the formula to provide mood and energy support.

Pros

  • With GABA as a key ingredient, these soft gels offer rapid stress relief within 30-60 minutes of consumption.
  • It is formulated with a carefully selected combination of botanicals and nutrients known for their calming properties, ensuring effective stress management.
  • Each bottle contains 60 soft gels that provide a 30-day supply when taken as directed.
  • OLLY products are made with high-quality ingredients and are free from GMOs, synthetic flavors, and colors.
  • The soft gel format makes these supplements easy to take with water, with a hint of strawberry scent and zero sugar.

Cons

  • While generally well-tolerated, individual responses to supplements can vary, and some users may not experience the desired effects.
FORCE FACTOR GABA 750mg Capsules

FORCE FACTOR GABA 750mg Capsules contain pure gamma-aminobutyric acid (GABA), which is a neurotransmitter known for reducing nervous tension and promoting relaxation. Each capsule is vegan-friendly, non-GMO, and designed to support neurotransmitter health for those experiencing anxiety, stress, or sleep disturbances. With 100 capsules in each bottle, it offers a substantial supply for consistent use.

Pros:

  • Supports calm and relaxation
  • Promotes healthy sleep and focus
  • Vegan and non-GMO
  • High-potency GABA (750mg)

Cons:

  • Some users may need to adjust dosage based on sensitivity
  • Results may vary between individuals

Designs for Health NeuroCalm - 5HTP GABA L-Theanine Supplement for Stress Response

See price on Amazon

After using this supplement for a few weeks, our general mood and stress levels have steadily improved. The relaxing effects are not overpowering, yet they are beneficial nonetheless. Thanks to NeuroCalm, we have also experienced less tension associated with worry and better quality sleep. We can feel secure about what we're putting into our bodies because it's vegan and manufactured with pure ingredients.

Pros:

  • Combines multiple calming ingredients
  • Methylated B12 for better absorption
  • Vegan-friendly and easy to digest
  • Includes chamomile for added soothing effects

Cons:

  • May take a few weeks to notice full effects
  • Higher price point compared to similar products

Thorne PharmaGABA-100

See price on Amazon

Thorne PharmaGABA-100 stands out as one of the best GABA supplements for sleep, fostering a tranquil mental state and promoting rejuvenating sleep. With each capsule containing 100 mg of natural source GABA, this product epitomizes excellence in addressing stress and facilitating relaxation, making it an unparalleled choice for those seeking holistic well-being. Thorne's unwavering dedication to quality permeates every aspect of this formulation, from its meticulously selected ingredients to its meticulous manufacturing standards.

Pros

  • Thorne's commitment to uncompromising quality shines through its rigorous testing and manufacturing protocols, ensuring every capsule's utmost purity and potency.
  • The optimal 100 mg dosage of GABA per capsule strikes a harmonious balance between efficacy and safety, catering to most adults seeking relaxation and enhanced sleep quality.
  • By fostering a serene and focused mental state, Thorne PharmaGABA-100 aids in alleviating stress levels and facilitating deep, restorative sleep, thereby contributing to overall mental and physical wellness.
  • Crafted without gluten, soy, dairy, shellfish, or fish, this formulation accommodates individuals with diverse dietary restrictions or sensitivities, reflecting Thorne's commitment to inclusivity.
  • The vegetarian capsules crafted from hypromellose further broaden the accessibility of this product to a broader audience, aligning with various lifestyle choices and preferences.

Cons

  • While Thorne PharmaGABA-100 offers unparalleled quality, its premium formulation comes at a slightly higher price point than some competing brands.
  • This supplement exclusively comes in capsule form, which may not suit all individuals' preferences, particularly those favoring alternative delivery methods like liquid or chewable supplements.
  • Although uncommon, some users may experience mild side effects such as headaches or grogginess, especially during the initial stages of supplementation. However, these effects typically diminish with continued use.
  • Individuals requiring a higher GABA dosage may find it necessary to consume multiple capsules to achieve their desired therapeutic effect, potentially resulting in increased long-term costs.
NOW Supplements GABA + B-6

NOW Supplements offers a top-notch solution for those seeking relief from anxiety with their GABA 500 mg + B-6 capsules. GABA, a naturally occurring neurotransmitter, promotes relaxation and easing nervous tension within the central nervous system. NOW Supplements combines this essential amino acid with Vitamin B-6, enhancing its effectiveness and supporting overall brain health.

Pros

  • NOW Supplements adheres to strict quality standards, ensuring purity and potency in every capsule.
  • With 500 mg of GABA per serving, it provides a potent dose for effective anxiety relief.
  • The addition of Vitamin B-6 enhances the absorption and utilization of GABA in the body.
  • Suitable for various dietary preferences, including vegetarian, vegan, and kosher diets.
  • Made in the USA by a family-owned and operated company with a history of excellence since 1968.

Cons

  • While effective, some users may find the large size of the capsules challenging to swallow.
  • Individual responses to GABA supplementation may vary, with some users experiencing drowsiness during the day.
  • Requires consistent daily use for optimal results, which may not be convenient for everyone.
Pure Encapsulations GABA

Pure Encapsulations GABA is a top-tier supplement designed to offer unparalleled support for relaxation and the moderation of occasional stress. With its premium GABA amino acids, this product stands out as one of the best options for those seeking relief from anxiety and stress-related symptoms.

Pros

  • Pure Encapsulations is renowned for its dedication to excellence and purity. This supplement undergoes thorough testing to guarantee adherence to the most stringent standards, delivering users a dependable and efficient product.
  • Formulated specifically to support relaxation, this supplement helps users manage stress more effectively, promoting a sense of calm and well-being even in the face of occasional stressors.
  • GABA plays a crucial role in immune health, particularly during periods of mild stress. By moderating occasional stress, this supplement may indirectly support immune function, contributing to overall well-being.
  • GABA is a key neurotransmitter in the central nervous system, regulating cell-to-cell communication. By aiding the proper function of the nervous system, this supplement helps maintain overall health and vitality.
  • Pure Encapsulations products are free from artificial ingredients, common allergens and GMOs, making them suitable for individuals with various dietary restrictions and preferences.

Cons

  • While Pure Encapsulations is a reputable brand, its products may be less readily available in certain regions or stores than more mainstream brands. This could pose a challenge for users seeking immediate access to the product.
Anxie-T - Stress Relief Supplement

Anxie-T is a standout stress relief supplement meticulously crafted to support mood and mental focus. It stands out as the premier GABA supplement for anxiety relief, offering a comprehensive blend of natural ingredients designed to promote calmness and relaxation. With its clinically tested ingredients such as Ashwagandha, Kava Kava, L-theanine, and Theobromine, Anxie-T targets common symptoms of stress, including nervousness, stress-related muscle tension, and sleep problems.

Pros

  • Most users experience the calming effects of Anxie-T within the first day of use, often within 30 minutes, promoting a sense of calm without inducing drowsiness.
  • The recommended dosage of three Anxie-T capsules each morning, with or without food, can be supplemented with an additional capsule at night for improved sleep quality.
  • Anxie-T incorporates premium ingredients sourced from plants and amino acids, including Ashwagandha, Kava Kava, L-theanine, and GABA, which are known for their stress-relieving properties.
  • Rather than relying on multiple supplements, Anxie-T combines key ingredients in one therapeutic dosage, simplifying the process of stress management.
  • Formulated by healthcare professionals, Anxie-T is designed to provide maximum potency and efficacy, ensuring optimal stress relief for users.

Cons

  • Certain users have experienced minor side effects such as stomachaches, headaches, and restless sleep after taking Anxie-T, though experiences vary.
  • While effective, Anxie-T may be slightly more expensive compared to other stress relief supplements on the market.
  • Results may vary depending on individual stress levels and sensitivity to the ingredients, requiring some users to give the supplement a full 30 days to assess its effects accurately.
Jarrow Formulas GABA Soothe

Jarrow Formulas GABA Soothe offers a comprehensive stress relief and relaxation approach with its unique blend of clinically studied ingredients. This supplement features three well-known components: GABA, L-Theanine, and Withania somnifera (Ashwagandha) Extract, all combined in one convenient capsule. Designed to promote calmness and mental focus, it's a go-to choice for individuals seeking support during occasional periods of stress.

Pros

  • With its three clinically studied ingredients, Jarrow Formulas GABA Soothe provides a holistic approach to relaxation and stress relief, addressing multiple aspects of mental well-being in one convenient supplement.
  • This vegan, non-GMO, gluten-free, and dairy-free supplement is formulated without soybeans, eggs, fish, shellfish, peanuts, tree nuts, or sesame, making it suitable for various dietary preferences and restrictions.
  • With just one capsule per day, taken with water or juice on an empty stomach, users can effortlessly incorporate this supplement into their daily routine to support relaxation and resistance to occasional stress.
  • Many customers praise the efficacy of Jarrow Formulas GABA Soothe in helping them manage stress and anxiety, with some users reporting significant improvements in sleep quality and overall well-being.
  • Jarrow Formulas is known for its commitment to scientific research and product quality, providing consumers with confidence in the safety and effectiveness of their supplements.

Cons

  • Although rare, some individuals might encounter mild side effects like drowsiness or gastrointestinal discomfort, especially when initiating a new supplement routine.
Source Naturals GABA Calm

Source Naturals Serene Science GABA provides a powerful solution for persons seeking relief from anxiety and stress. Each capsule containing 750mg of GABA, an essential amino acid and key inhibitory neurotransmitter. This supplement aims to support a calm mind and promote muscle relaxation.

GABA serves as a chemical messenger in the brain, facilitating communication between nerve cells and promoting a sense of tranquility and relaxation. By helping to regulate neuronal activity, GABA may help reduce anxiety and promote mental well-being.

Pros

  • With each capsule containing 750mg of GABA, this supplement offers a potent dose to support relaxation and calmness.
  • GABA is a naturally occurring compound in the body, making it a safe and effective option for those seeking natural anxiety relief.
  • Formulated without dairy, egg, gluten, soy, or wheat, this supplement is well-suited for individuals with dietary restrictions or sensitivities.
  • Free from common allergens such as yeast, this supplement provides a hypoallergenic option for those with sensitivities.
  • With over 35 years of experience, Source Naturals is a trusted name in the supplement industry, committed to quality and efficacy.
  • Manufactured in a Scotts Valley, California facility, this supplement meets strict quality and safety standards.

Cons

  • Some individuals may find the size of the capsules difficult to swallow.
  • While many users experience positive effects, individual responses to GABA supplementation may vary.
  • Due to high demand, this product may occasionally be out of stock or less readily available from certain sellers.

Final Thoughts

Among the best GABA supplements for anxiety relief, Thorne PharmaGABA-100 stands out as the premier choice. Thorne's unwavering commitment to quality and rigorous testing ensures that every capsule delivers pure, potent GABA sourced from natural ingredients. With its optimal 100mg dosage per capsule, Thorne PharmaGABA-100 strikes the perfect balance between efficacy and safety, fostering a serene mental state and promoting deep, restorative sleep.

Whether you're struggling with occasional stress, persistent anxiety, or sleep disturbances, Thorne PharmaGABA-100 offers a natural, holistic solution. By incorporating this best GABA supplement into your daily routine, you can take control of your well-being and experience the calm, focused mindset you deserve.

FAQs on the Best GABA Supplements for Anxiety Relief

How do the best GABA supplements help with anxiety?

GABA reduces the activity of neurons in the brain, potentially leading to a calming effect on the body. This can help address symptoms of anxiety and promote relaxation.

What are the best forms of GABA supplements?

GABA supplements are available in various forms, such as capsules, powders, and liquids. Each form has its own benefits, depending on personal preferences and lifestyle needs​.

What is the recommended dosage for GABA supplements?

Dosages can vary widely but generally range from 100 mg to 800 mg per day, depending on the individual's needs and the specific supplement's instructions​.

Are there natural sources of GABA?

Yes, GABA can be found in fermented foods like yogurt, kefir, and certain vegetables. These natural sources can help increase GABA levels in the body.

Share your story
Once your story receives approval from our editors, it will exist on Buoy as a helpful resource for others who may experience something similar.
The stories shared below are not written by Buoy employees. Buoy does not endorse any of the information in these stories. Whenever you have questions or concerns about a medical condition, you should always contact your doctor or a healthcare provider.
Jeff brings to Buoy over 20 years of clinical experience as a physician assistant in urgent care and internal medicine. He also has extensive experience in healthcare administration, most recently as developer and director of an urgent care center. While completing his doctorate in Health Sciences at A.T. Still University, Jeff studied population health, healthcare systems, and evidence-based medi...
Read full bio

Was this article helpful?

Tooltip Icon.