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Written by Andrew Le, MD.
Last updated August 15, 2024

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Introduction

Fly bites are a common annoyance that can turn a pleasant time outdoors into an itchy, uncomfortable ordeal. These tiny insects may seem harmless, but their bites can cause more than just minor irritation. In this guide, we'll explore fly bites, covering everything from the types of flies that bite to the diseases they can transmit. We'll look at the causes and types of fly bites, examine the symptoms and reactions they cause, discuss prevention and treatment methods, and help you identify different biting flies.

Causes and Types of Fly Bites

Flies bite for a simple reason: they need blood to reproduce. Female flies of certain species need a blood meal to develop their eggs. This is what drives them to seek out humans and animals as potential food sources. While male flies typically feed on nectar and other plant juices, the females are responsible for those annoying bites.

Let's take a closer look at some common types of biting flies:

Mosquitoes

Mosquitoes are perhaps the most well-known biting flies. These small insects can transmit serious illnesses like Zika, West Nile virus, and malaria. 3,4 Their bites often cause small, itchy bumps that can become painful, swollen welts in some people, a condition known as "skeeter syndrome". 4 Mosquitoes are found worldwide and are most active during dawn and dusk.

Deer Flies and Horse Flies

Deer flies and horse flies are larger and known for their painful bites. Deer flies are about 1/4 to 1/2 inch long with dark bands on their wings and often gold or green eyes. 3,5 Horse flies are usually entirely black, though some species called "greenheads" have shiny green eyes. 5,8 Both use sharp mouthparts to cut the skin and feed on blood, which can be very painful. 3,5 These flies are commonly found near wooded areas and water sources.

Stable Flies

Stable flies look like house flies but have a pointed proboscis (nose) for sucking blood. 8 They typically bite livestock but will also go after humans, especially around the ankles. 2,8 Their bites can be painful and may cause itchy, red bumps. 2 Stable flies are particularly common around livestock areas and can be found in various parts of the United States, including New Jersey, Lake Michigan shorelines, the Tennessee Valley, and the Florida panhandle. 34

Black Flies

Black flies, also known as buffalo gnats, are small, hump-backed flies that have a painful bite. 2,6 While they don't transmit diseases in the United States, their bites can cause severe allergic reactions in some people, including swelling, bleeding, and intense itching. 6,5 Black flies are most active during the day and are commonly found near streams and rivers where their larvae develop. 35

Sand Flies

Sand flies are small, hairy flies found in tropical and subtropical regions. 1,3 Their bites can be painful and may cause red bumps or blisters. 3 In some parts of the world, sand flies can transmit leishmaniasis, a parasitic disease that causes skin sores. 1,3 Sand flies are typically found in warm, humid environments and are most active during twilight hours.

Biting Midges

Biting midges, often called no-see-ums or punkies, are tiny flies with surprisingly painful bites. 2,2 These insects are usually no larger than 1/32 of an inch and are often found near water sources. 2,14 Biting midges are typically near coastal areas and can easily enter homes through window and door screens because they are so small. 32,33

Risk factors for fly bites depend on the species. Some flies, like mosquitoes, are found worldwide, while others have more limited ranges. 9,12 Factors that can increase the risk of fly bites include:

  • Time of day: Many biting flies are most active during dawn and dusk. 4,9
  • Water: Many species breed in or near water sources. 7,14
  • Outdoor activities: Hiking, camping, and working outdoors can expose you to more flies. 9,10
  • Climate: Warm, humid conditions are preferred by many biting fly species. 11,13

Understanding these factors can help you better prepare for and avoid potential fly bites.

Symptoms and Reactions to Fly Bites

Fly bites can cause a range of symptoms depending on the type of fly involved and your personal reaction. Most fly bites cause minor discomfort, including:

  • Pain
  • Itching
  • Swelling
  • Redness

However, the severity and specific symptoms can vary based on the fly species and your sensitivity. Let's explore the reactions to different types of fly bites:

Mosquito Bites

Mosquito bites typically cause small, itchy bumps. In some people, these bites can develop into larger, more painful welts. This severe reaction, known as "skeeter syndrome," can cause significant swelling and discomfort. 4

Deer Fly and Horse Fly Bites

Deer fly and horse fly bites can cause intense pain. The bite site often becomes red, swollen, and itchy. In some cases, these bites can cause large, itchy welts that last for several days. 1,3

Black Fly Bites

Black fly bites can cause a range of reactions, from a small puncture wound to a swollen bump the size of a golf ball. 36,4 Severe reactions, collectively called "black fly fever," may include headache, nausea, fever, and swollen lymph nodes. 6,38

Sand Fly Bites

Sand fly bites can be painful and may cause red bumps and blisters. In some cases, these bites can cause skin inflammation (dermatitis). 3,16

Biting Midge Bites

Biting midge bites, despite the tiny size of the insect, can be surprisingly painful. They often cause small, intensely itchy red bumps. 28,29

Stable Fly Bites

Stable fly bites are often painful but rarely cause allergic reactions. They typically target the ankles and lower legs, causing red, itchy bumps. 1

While most fly bites cause only minor discomfort, some people may experience more severe reactions. These can include:

  • Allergic reactions: Some people may develop severe allergic reactions to fly bites, ranging from mild irritation to life-threatening anaphylaxis. Symptoms of a severe allergic reaction can include:
  • Difficulty breathing
  • Swelling in areas away from the bite site
  • Dizziness or weakness
  • Hives 15,17
  • Infection: Scratching fly bites can lead to secondary bacterial infections. Signs of infection include increased redness, warmth, swelling, and pus at the bite site. 3,22
  • Disease transmission: While most fly bites in the United States don't transmit diseases, some flies can spread pathogens. For example, deer flies can occasionally transmit tularemia, a bacterial infection that causes skin ulcers, fever, and headache. 3
  • Serum sickness: In rare cases, insect bites can trigger serum sickness, an unusual reaction that occurs hours or days after the bite. Symptoms may include fever, joint pain, flu-like symptoms, and hives. 17,18

It's important to note that personal reactions can vary. Some people may experience only mild discomfort from fly bites, while others may have more severe reactions. If you experience severe symptoms or signs of infection following a fly bite, seek medical attention promptly.

Preventing and Treating Fly Bites

Prevention is always better than cure when it comes to fly bites. By being proactive, you can reduce your risk of being bitten and avoid the discomfort and potential health risks caused by fly bites. Here are some effective ways to prevent fly bites:

Personal Protection

  • Use insect repellents: Apply EPA-approved insect repellents with ingredients like DEET, Picaridin, or oil of lemon eucalyptus. 28 These repellents are effective against a wide range of biting flies.
  • Wear protective clothing: When outdoors, especially in areas with many flies, wear long-sleeved shirts, long pants, and closed-toe shoes. 20,21 Some flies are attracted to dark colors, so wear light-colored clothing.
  • Use mosquito netting: When camping or sleeping outdoors in areas with high fly populations, use mosquito netting around your sleeping area and over strollers and infant carriers.
  • Avoid peak biting times: Many biting flies are most active during dawn and dusk. Limit outdoor activities during these times in areas with flies. 4,9
  • Stay away from breeding sites: Avoid areas near standing water, marshes, or dense vegetation where flies often breed and congregate.

Environmental Control

  • Get rid of standing water: Many fly species, including mosquitoes, breed in standing water. Remove or regularly empty items that collect water around your home, such as birdbaths, old tires, and flower pots. 23,24
  • Keep your surroundings clean: Properly dispose of organic waste and keep your yard clear. This can help reduce fly populations around your home. 23,24
  • Use screens: Install and maintain screens on windows and doors to prevent flies from entering your home. 23,24
  • Use fly traps: In areas with high fly populations, fly traps or sticky paper can help catch flies.
  • Encourage natural predators: Some birds, bats, and beneficial insects feed on flies. Creating a habitat that attracts these natural predators can help control fly populations.

Despite your best efforts, you can still get fly bites. When you do, prompt and proper treatment can help relieve symptoms and prevent complications. Here's how to treat fly bites:

  • Clean the bite area: Wash the affected area thoroughly with soap and water to reduce the risk of infection. 3,22
  • Apply a cold compress: Use a cold compress or ice pack to reduce swelling and numb the area. This will help alleviate pain and itching. 3,19
  • Use over-the-counter treatments: Antihistamines can help reduce itching and swelling. Topical treatments like calamine lotion or hydrocortisone cream can provide itch relief. 3,19
  • Avoid scratching: While it can be tempting to scratch the bite, this can increase the risk of infection. Try to resist the urge and use the treatments mentioned above instead.
  • Monitor for signs of infection: Keep an eye on the bite area for signs of infection, such as redness, warmth, or pus. If you get these symptoms, seek medical attention.
  • Consider natural remedies: Some people find relief from fly bites using natural remedies like aloe vera, tea tree oil, or a paste made from baking soda and water.

In most cases, fly bites will heal on their own within a few days. However, if you experience severe symptoms or signs of infection, seek medical attention promptly. This is particularly important if you develop symptoms of a severe allergic reaction or if you think you may have contracted a fly-borne disease.

Remember, prevention is key when it comes to fly bites. By taking proactive measures to protect yourself and control fly populations in your environment, you can reduce your risk of bites and enjoy outdoor activities with greater peace of mind.

Fly Bites and Associated Diseases

While most fly bites are merely annoying, some can transmit diseases to humans and animals. Here's an overview of some diseases associated with different types of biting flies:

Mosquito-Borne Diseases

Mosquitoes carry numerous diseases, including:

  • West Nile virus: This viral infection can cause fever, headache, and in severe cases, neurological complications. 6,37
  • Zika virus: This virus causes mild symptoms in adults but can lead to serious birth defects if a pregnant woman is infected. 6,37
  • Malaria: Although rare in the United States, malaria is a serious and sometimes fatal disease caused by parasites spread through mosquito bites. 6,37

Deer Fly and Horse Fly-Borne Diseases

Deer flies can transmit tularemia, also known as "rabbit fever." This bacterial disease can cause skin ulcers, fever, and headache. 48,49 In recent years, tularemia has spread more in the United States, with clusters of cases reported in some regions. 50,51

Sand Fly-Borne Diseases

Sand flies are known to transmit leishmaniasis, a parasitic disease that can cause skin sores and, in some forms, affect internal organs. 45,46 While leishmaniasis is more common in tropical and subtropical regions, there have been recent reports of cases in the southern United States, particularly in Texas, Florida, Oklahoma, and Arizona47.

Black Fly-Borne Diseases

While black flies in the United States don't typically transmit diseases to humans, they can carry a parasitic worm that causes river blindness in other parts of the world. 39,40

Biting Midge-Borne Diseases

In some regions, biting midges can spread viruses like bluetongue to livestock. 43,44 While these diseases mainly affect animals, they can have significant economic impacts on agriculture.

Conclusion

Fly bites, while often seen as mere nuisances, can pose health risks in certain situations. Understanding the different types of biting flies, their habitats, and the diseases they can potentially transmit can help you prevent and control them.

By taking personal protective measures, supporting public health initiatives, and staying informed about fly-borne disease risks in your area and when traveling, you can significantly reduce your risk of experiencing complications from fly bites. Remember, while the risk of contracting a serious disease from a fly bite in the United States is generally low, it's always better to err on the side of caution and take preventive measures. Stay informed, stay protected, and enjoy the outdoors safely.

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Dr. Le obtained his MD from Harvard Medical School and his BA from Harvard College. Before Buoy, his research focused on glioblastoma, a deadly form of brain cancer. Outside of work, Dr. Le enjoys cooking and struggling to run up-and-down the floor in an adult basketball league.

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