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Top 12 Best Choline Supplements

Written by Andrew Le, MD

UpdatedNovember 13, 2024

Choline belongs to the vitamin B complex family, and it has multiple functions in the body such as in the liver, brain, and muscles. Still, the majority of individuals cannot meet their daily requirement of choline through the food products consumed and this is where one takes products containing choline. There are those supplements which can be taken in order to replenish the body with choline that may be lacking in a person’s diet.

These are some of the options of choline supplements which are available; these include choline bitartrate, alpha-GPC, and citicoline. Every type has different advantages and disadvantages so it is important to decide which one will work best for you.

Top 3 Best Choline Supplements

  1. Nested Naturals Choline Supplement
  2. NOW Choline & Inositol Capsules
  3. PURE SYNERGY Choline Complex

If you're looking to boost your cognitive function, improve your memory, or enhance your overall brain health, choline supplements might be worth considering. Choline is an essential nutrient that plays a crucial role in brain development, nerve function, and metabolism. While choline can be found in certain foods like eggs, liver, and soybeans, many people find it challenging to get enough choline from their diet alone. That's where choline supplements come in.

We've researched and tested various choline supplements on the market to bring you the best options available. Whether you're a student looking to improve your focus or an older adult hoping to support your brain health, we've got you covered. Check out our top picks for the best choline supplements below.


Nested Naturals Choline Supplement

Editor's Choice

Nested Naturals Choline Supplement

Discover Nested Naturals Choline Supplement—a vegan, non-GMO gem supporting brain health & nervous system. Ideal for moms-to-be. Yet, watch for a fishy odor reported by users, misleading labeling (split dosage), and large capsules. Despite quirks, it's a solid option, just mind the caveats before diving in.

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If you are looking for vegan and non-GMO choline supplement then you might want to check out the Nested Naturals Choline Supplement.

A Choline Supplement from Nested Naturals is perhaps one of the best ways to support your nervous system and your brain. It is mostly beneficial for pregnant and breastfeeding mothers because they require additional choline for the well-being of the baby. It can also postively impact your liver health and the way your body breaks down fats in your body.

There are, however, some complaints of users who stated that the supplement produced strong fish smell. Essential information is also not well presented on the label where people are led to believe that they are getting 180 capsules when in fact, the 550 mg dose is divided between two. At last, for this type of Consumers the capsules are fairly large and could be a problem for those who find it hard to swallow pills.

All in all, if you are in the search of choline which is vegan and non-GMO, then the Nested Naturals Choline Supplement is good to go for. It is therefore important to be aware of some negatives likely to be associated with the above purchase .

Pros

  • Supports brain and nervous system
  • Contains 500mg of choline for pregnant and breastfeeding mothers
  • Helps support the liver and metabolism of fatty acids

Cons

  • Strong fish odor
  • Misleading product label
  • Capsules are large

NOW Choline & Inositol Capsules

NOW Choline & Inositol Capsules

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NOW Choline & Inositol Capsules are one of the best choline supplements if you’re seeking a product that contributes to proper nerve impulse conduction and fatty acid processing.

I have been using NOW Choline & Inositol Capsules for several weeks, and I’ve certainly seen an improvement in my memory. My memory has increased, and I have also been able to enhance my concentration when attending to duties at the workplace. I also like that these capsules are Kosher, Non-GMO, and Soy-Free.

Which, brings one into consideration about the fact that the capsules are fairly large and if you are one of those who find it difficult to swallow pills, then consider opting for the other supplements in choline. Also, there are certain side effects that are related to digestion, where users may feel the need to have diarrhoea after taking these capsules as its dosage may build up too much and hence, the best thing to do is to start with a small dose and gradually work your way up to the recommended quantity.

NOW Choline & Inositol Capsules may not be as potent for some people regarding the choline content but I believe they are good and recommended for people who want to support healthy nerve transmission and fatty acid metabolism. In conclusion, I would vouch for these capsules if you happen to be in the market for a choline supplement.

Pros

  • Supports healthy nerve transmission
  • Assists in fatty acid metabolism
  • Kosher, Non-GMO, and Soy-Free

Cons

  • Capsules are relatively large
  • Some users may experience digestive discomfort
  • May not be as effective as other choline supplements for certain individuals

PURE SYNERGY Choline Complex

PURE SYNERGY Choline Complex

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If you are searching for a choline supplement that is made from organic vegetables and sprouts and is fermented to be assimilated as food then the choice is PURE SYNERGY Choline Complex.

Choline Complex is ideal to be taken as supplement to enhance the healthy condition of one’s brain as well as the nervous system. This is also essential during pregnancy for proper brain development in the fetus. Also, it contributes to the proper functioning of the liver besides affecting the formation of bile and fats.

The tablets are organic, non GMO, free from any gluten, they do not contain any animal products and are dairy free. Nevertheless, the tablets are sticky and offer only a poor separation of each one in the aluminium foil. The tablets also have a slight odour of greens and are slightly large in size, approximately 3/4 an inch in diameter.

In conclusion, if you are interested in choline supplement, that is produced using organic materials and that is helpful for cognitive and liver functions then you can purchase a choline complex of pure synergy.

Pros

  • Made with organic vegetables and sprouts, and fermented so it’s absorbed just like food.
  • Promotes healthy cognitive function & supports brain & nervous system health.
  • Supports healthy liver function as well as healthy bile & fat metabolism.

Cons

  • Tablets are sticky and clumped together, making it hard to get one out.
  • Tablets have a slight smell, like greens.
  • Tablets are a little big, about 3/4 inch.

Ritual Natal Choline

Ritual Natal Choline

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If you're an expectant mother searching for a prenatal supplement, Ritual Natal Choline stands out as a noteworthy option. Packed with essential nutrients, this supplement aims to support both maternal and fetal health during pregnancy.

Pros

  • Easy-to-swallow capsules with no aftertaste
  • Choline content for optimal brain development in the fetus
  • Gentle on the stomach, suitable for sensitive pregnant individuals

Cons

  • Slightly higher price compared to other prenatal supplements
  • May not contain all the nutrients found in traditional prenatal multivitamins

One of the main benefits of Ritual Natal Choline is that it comes in easily-digestible capsules with no bad aftertaste. Choline is particularly worthy of notice because it is essential for the proper development of the fetus’s brain. Moreover, it is safe for those groups of people that have sensitive stomachs and pregnant women in particular.

However, one should also be aware of the reasonable fact that the price of this supplement may be higher than in regard to other similar supplements available in this market. Further, Ritual Natal Choline is similar to the traditional prenatal multivitamins, but it only focuses more on the nutrient that is choline and might not offer a collection of vitamins and minerals as extensive as the prenatal multivitamins.

Thus, for the women who are pregnant and are looking for a prenatal supplement that does not have a strict requirement of the type of product, is easy to consume, and will not upset the stomach, it is worthy to consider Ritual Natal Choline.


Jarrow Formulas Citicoline CDP Choline 250 mg Capsules

Jarrow Formulas Citicoline CDP Choline 250 mg Capsules

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This dietary supplement with 250 mg Citicoline will be perfect for people willing to maintain the brain in a good state daily and improve performance as well as memory.

That’s why this supplement is perfect for those who are seeking a moderate but evident enhancement of the thinking process. It is convenient and the recommended dosage pattern of the supplement is one capsule daily or twice a day with meals or as prescribed by your health care provider.

The Citicoline in this supplement improves energy metabolism in the brain in healthy adults and adolescents affecting the performance in attention. As a result, it is also gluten free and may be taken by people who have special diets.

Yet some users of this product complained of developing side effects like irritability, throat mucus, and if it is taken daily may lead to developing a headache. Also, available in the market much more effective goods for lowered cost.

In conclusion, if you are in the market for the best choline supplement for daily brain functions, performance, and memory improvement, Citicoline CDP Choline 250 mg Capsules Jarrow Formulas is a perfect supplement to go with.

Pros

  • Provides daily brain health, performance, and memory support
  • Supports brain energy metabolism and attention performance in healthy adults and adolescents
  • Contains one 120 count bottle of Jarrow Formulas Citicoline CDP Choline 250 mg Capsules for a 60- to 120-day supply

Cons

  • May cause headaches if taken every day
  • Some users reported side effects such as irritability and throat mucus
  • Better alternatives are available for lesser price

NusaPure Choline Bitartrate 650 mg.200 Veggie Capsules

NusaPure Choline Bitartrate 650 mg.200 Veggie Capsules

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If you want to buy a top-grade choline supplement, NusaPure Choline Bitartrate is one of the best products in the market.

All in all, NusaPure Choline Bitartrate appears to be a very good option if you want to get a perfect choline supplement. The 650 mg per serving is enough to receive the effect of choline and that the product is Vegan/Vegetarian friendly, Non-GMO, and Glutne-Free is a plus. And that, it is made in the USA and in the cGMP registered facility, so the quality should be reliable.

With this in mind, some of the capsules can be a little large to ingester, and some users have also reported some minor side effects such as headaches, or upset stomachs. In the same regard, the product’s cost is slightly higher compared to some of the choline products available in the market.

If you want to invest in a good quality choline supplement I would strongly advise ordering NusaPure Choline Bitartrate.

Pros

  • Provides 650 mg per serving, which is a good amount to get the benefits of choline.
  • Suitable for vegan/vegetarian diets, non-GMO, and gluten-free.
  • Made in the USA in a cGMP registered facility, so you can trust the quality.

Cons

  • Some users might find the capsules a bit large to swallow.
  • A few users have reported mild side effects like headaches or stomach upset.
  • The product is a bit more expensive than some other choline supplements on the market.

Standard Process Choline

Standard Process Choline

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If you are looking to purchase a high potency choline supplement formulated to demonstrate sound liver and gallbladder support as well as the nervous system then Standard Process Choline might indeed be what you require.

Standard Process Choline can be recommended to people, who want to take a natural product that has a positive impact on the state of the whole organism. It has choline bitartrate and honey combination that can help in methylation process and has functions like supporting liver and gall bladder health and nervous system.

Herein, there is one possible negative effect of this supplement, namely the increased prevalence of gastrointestinal discomfort in some people. However, some users have stated that they did not feel any changes when they have consumed this product. Last but not the least, this supplement is known to pose some risks for the persons having gallbladder problem, thus, one should consult the doctor before consuming it.

All in all, if you are truly interested to get choline supplements which are of the best quality, then Standard Process Choline is one of the best to try. The importance of balanced nutrition and its positive effect on the human body is beyond doubt, while the natural ingredients provide even more advantages.

Pros

  • Provides support for methylation reactions
  • Supports healthy liver and gallbladder function
  • Supports a healthy nervous system

Cons

  • May cause stomach upset in some individuals
  • Some users report not noticing any significant difference
  • May not be suitable for individuals with gallbladder issues

Double Wood Supplements CDP Choline Supplement

Double Wood Supplements CDP Choline Supplement

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For probably the most effective choline dietary supplement, the Double Wood Supplements CDP Choline Supplement, it can assist with memory formation and retention, working memory, focus, and energy.

This product is made in the USA and has 300mg of CDP Choline which is pharmaceutical grade per capsule. I bought the gluten-free biscuits for my friends, who are now in their 30s and concern about their energy intake.

Overall, if you are in need of a product that can help boost your mental capabilities and could consider taking supplements for the same, then maybe this product is for you. However, the program has been reported to have side effects among some users like headaches and upset stomach, and should not be used especially by patients with some conditions.

In conclusion, if you want to get a high-quality choline supplement that may improve the memory and cognition level, the Double Wood Supplements CDP Choline Supplement is the thing you will not regret to try.

Pros

  • Promotes choline levels effectively
  • Supports memory formation and retention
  • Supports cognitive function

Cons

  • May cause headaches or stomach upset in some individuals
  • May not be suitable for those with certain medical conditions
  • Some users may not experience noticeable benefits

NATURAL STACKS Acetylcholine Brain Food

NATURAL STACKS Acetylcholine Brain Food

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So if you are having issues with mental clarity and focus, NATURAL STACKS Acetylcholine Brain Food will be of great help to you.

NATURAL STACKS Acetylcholine Brain Food is a highly effective and robust nootropic that is meant for increasing the choline levels in your body which in turn helps to produce more of the well known ‘learning molecule’. It includes Alpha-GPC, an ultra-nootropics that helped patients to enhance cognitive abilities clinically, vitamins B1 and B5 to support the ultimate mental sharpness, crucial alertness and concentration.

It has accurate proportions of each component that are used in research that makes the formula efficient and effective. In this sense, it can be appreciated as a tune up that can be done anytime to get the brain off the cloud nine, get rid of brain haze and effectively think and store information.

NATURAL STACKS is the leading brand in brain supplements and the products are the highest quality natural ingredients, clearly labeled, open-source, and are thoroughly tested for purity and strength. You are covered with their happiness guarantee, which means if anything goes wrong, all you need to do is to contact them and they will sort it out for you.

NATURAL STACKS Acetylcholine Brain Food is one of the best choline supplements that can help you improve your mental performance if you want to give it a try.

Pros

  • Helps improve mental clarity and focus
  • Contains high-quality natural ingredients
  • Comes with a 100% happiness guarantee

Cons

  • Expensive compared to other choline supplements
  • May take some time to see noticeable results
  • May not work for everyone

Horbäach Choline Bitartrate

Horbäach Choline Bitartrate

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This brand is recommended if you are searching for a potent choline supplement for your body – Horbäach Choline Bitartrate.

Speaking personally, Horbäach Choline Bitartrate I have used is different compared to the rest because of the potent quality of the supplement. The capsules are easy to swallow and does not leave bad breath in the mouth only that they are a little big in size. I like the fact that this supplement is has no gluten, artificial flavors and sweeteners and is non-GMO. I also enjoyed reading about Horbäach’s policy dealing with the purity and potency of the products they produce.

All the same, it is probable to state I will agree with the assertion that everyone would be bound to benefit from this supplement in equal proportions. Furthermore, it is always recommended to first consult a healthcare professional as with any supplement if you have medical issues or take medications.

All in all, if the consumer wants to obtain a premium quality choline, Horbäach Choline Bitartrate will be an optimal choice. All that is required is that you consult with your healthcare provider before you pop it because each may not be safe or best suited for everyone.

Pros

  • Provides 410 mg of choline per capsule, which is 75% of the daily value
  • Gluten-free, non-GMO, and free of artificial flavors and sweeteners
  • Backed by Horbäach's commitment to purity and potency

Cons

  • Some users may find the capsules difficult to swallow
  • May not be suitable for individuals with certain medical conditions or who are taking certain medications
  • Some users may not notice significant benefits from taking this supplement

Horbäach Choline Inositol Supplement

Horbäach Choline Inositol Supplement

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You will get high quality choline through Horbäach Choline Inositol Supplement if you are in search of a supplement for it.

This supplement is specifically designed and developed with Choline Inositol to give out quick-release capsules and is completely scientific and professional. Due to the active ingredients in lecithin and members of the B-vitamin family, it is beneficial for any person who desires to improve their cerebral and cognitive states.

Also, Horbäach Choline Inositol Supplement has no gluten, wheat, yeast, lactose, artificial sweetener, preservatives, and non-GMO. For this reason, it is ideal for individuals who may have specific diet requirements or individuals who would want to take a very clean and pure supplement.

Of course, taking this supplement might be a problem for the soy allergic people, however, the reactions of most consumers are almost negligible. This is some natural formula that, if taken on a regular basis, should contribute to a better memory, concentration and overall brain functioning.

In conclusion, Horbäach Choline Inositol Supplement is a well-made product that can assist in improving the consumer’s brain functions. It is quite simple to make a conclusion if you want an effective and safe choline supplement this might be your perfect choice.

Pros

  • Choline Inositol: Active compounds naturally found in lecithin and members of the B-vitamin family
  • Scientific Formula: Features 1000 mg Choline Inositol per serving in quick release capsules
  • Expertly Crafted: Our professional formula is backed by our commitment to purity and potency

Cons

  • May not be suitable for those with allergies to soy
  • Some users may experience mild side effects such as stomach upset or headaches
  • Requires consistent use to see optimal results

Klaire Labs CDP Choline 250mg

Klaire Labs CDP Choline 250mg

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If you want a choline supplement to help your memory, attention, and focus, then the Klaire Labs CDP Choline 250mg supplement is the perfect one for you.

Klaire Labs CDP Choline 250mg is the hypoallergenic* formula that this supplement does not contain any allergens including milk/casein, eggs, fish, shell fish, tree nuts, peanuts, wheat, gluten, soy and corn as well as yeast. It has no added colours, taste enhancers or conservatives.

This choline supplement is recommended by healthcare professionals and has been since 1969, and it is created in collaboration with physicians to exhibit maximum results, even in those who are highly sensitive to choline.

If you are in search of a choline supplement that will help with memory, attention, and focus the Klaire Labs CDP Choline 250mg meets it. It provides the biologically active form of choline, and citicoline is one of the most investigated substances aimed at improving memory and cognition. This brain supportive nutrient is a backbone of phosphatidylcholine, glycerophosphatidylcholine as well as acetylcholine hence makes it ideal to those who want to boost their brain’s capacity.

Nonetheless, Klaire Labs CDP Choline 250mg might be a a little expensive to some people and one might need to take more than one capsule in a day if the drug is being taken for health complications. While some people might observe sweating, excessive blinking, or minor headaches, or nausea, this should be a good recommendation for those interested in wanting to boost their cerebral function.

Pros

  • Supplies the bioavailable, active form of choline.
  • Citicoline is among the best-studied agents for supporting memory function and healthy cognition.*
  • This brain supportive nutrient is a precursor of phosphatidylcholine, glycerophosphatidylcholine, and acetylcholine.

Cons

  • It may be a bit pricey for some people.
  • You may need to take more than one capsule a day if you're taking this for medical reasons.
  • Some people may experience mild side effects, such as headaches or nausea.

Buying Guide

When looking for the best choline supplement, there are a few key factors to consider. Here are some features to look for:

1. Type of Choline

Some forms of choline include choline bitartrate, citicoline and alpha-GPCs are the most common brands of choline supplements. Both have advantages and disadvantages, and that means it is advisable to go for the most appropriate one.

Choline bitartrate is probably one of the best-known forms of choline in supplements and can sometimes be the cheapest. Citicoline is more costly, but has potential extra advantage for the health of the brain. Alpha-GPC is also widely used choline supplement that can potentially be beneficial for the brain.

2. Dosage

The daily dose of the choline depends on the type of choline and the needs of the person who takes it. Care must be taken when selecting a supplement since this gives the right dosage for the body.

3. Form

Choline is sold in the pharmaceutical store in capsule, powder and liquid forms. Thus, the best choice belongs to capsules which are preferred by most individuals; powders and liquids are better for those with swallowing problems.

4. Quality

It is advisable to go for superior quality product from the right manufacturer when deciding on the right choline supplement to take. The supplements should be made from natural and premium quality ingredients without any adverse additions.

5. Additional Ingredients

Some choline supplements may contain additional ingredients, such as vitamins, minerals, or other nutrients. While these ingredients may provide additional benefits, it's important to choose a supplement that contains only the ingredients you need and that is free from unnecessary additives.

By considering these factors, you can choose the best choline supplement to meet your needs and support your overall health.

Frequently Asked Questions

1. What is the best form of choline to take?

It should be noted that form of a choline that has to be taken depends on the particular needs and desire of the individual. However, it is worth mentioning that among supplements containing choline, the most common ones are Alpha-GPC, CDP-choline, and choline bitartrate. These forms of choline are readily absorbed and can enter the cross blood-brain barrier therefore affecting the brain.

2. What supplement is best for choline?

As stated, there are two chief choline supplements they are Alpha-GPC and CDP-choline. These types of supplements are also very fat-soluble, and can quickly enter the brain via the bloodstream. In addition, they help boost cognition and memory as revealed by various studies on the subject.

3. Is it good to supplement with choline?

Choline is another nutrient that is more required for several body activities such as liver functioning, development of the brain and nerves. Though some persons may be able to get enough choline from food products, others may need a supplement to provide the daily demand.

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