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Top 8 Best DAO Supplements for Histamine Intolerance

Written by Andrew Le, MD

UpdatedJuly 30, 2024

Histamine intolerance is a common disorder that leads to the development of various symptoms including headache, skin rash, and gastrointestinal disturbances. A common remedy for histamine intolerance is to take DAO supplements. DAO or Diamine oxidase is an enzyme that metabolizes histamine in the human body and thus minimizes the effects of histamine intolerance.

When considering the best DAO supplement for histamine intolerance, there are several factors that one needs to consider. First of all, you need to know that the supplement should contain a high quality and pure form of DAO. Second, try to find a supplement that is very convenient to take and has the least adverse effects. Last but not the least, confirm if the supplement is from a well-known company and if it has undergone through trials to determine its safety and effectiveness.

Top 3 Best DAO Supplements for Histamine Intolerance

  1. Seeking Health Histamine Digest
  2. Bravado Labs Premium Histamine Block Supplement
  3. NATURDAOCOM LEGUMACTIVE

We know that it is irritating and uncomfortable to go through the signs of histamine intolerance like having a headache, rashes, and having stomach aches. That’s why, we have found and compared different DAO supplements to reduce the symptoms and enhance your quality of life. Here are the top DAO supplements for histamine intolerance that we recommend.


Seeking Health Histamine Digest - Formerly Histamine Block,

Editor's Choice

Seeking Health Histamine Digest - Formerly Histamine Block,

Seeking Health Histamine Digest is a reliable and fast-acting DAO supplement to alleviate histamine intolerance symptoms. It's free from common allergens and artificial ingredients. While it may not work for everyone, it's an effective option for managing histamine intolerance, provided you don't have allergies to those specific foods. Give it a try for natural relief.

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If you are suffering from histamine intolerance and seeking a good DAO supplement, then you may try Seeking Health Histamine Digest.

Pros

  • Histamine Digest is an effective DAO supplement that can help alleviate histamine intolerance symptoms like gas, bloating, and upset stomach.
  • The supplement is fast-acting and can be taken no more than 15 minutes before the consumption of histamine-rich foods or drinks.
  • Histamine Digest is free from eggs, fish, gluten, GMO, milk, peanuts, shellfish, soy, tree nuts, wheat, corn, artificial colors, artificial flavors, and artificial preservatives.

Cons

  • Histamine Digest is not designed to allow you to eat foods to which you are allergic, and it will not prevent allergic reactions.
  • The product may not work for everyone, and some users may experience side effects like nausea or headaches.
  • The stability testing for all Seeking Health products can take up to 2 years, so it's not always possible to mark newer releases with an expiration date.

From our own experience, we can state that Histamine Digest is a good and dependable DAO supplement that we have tested. That is, it has no common allergens and artificial ingredient which were nice features and it eased our histamine intolerance complains.

If you are in search of a natural and safe supplement to support your histamine intolerance, then you should try Seeking Health Histamine Digest.


Bravado Labs Premium Histamine Block Supplement

Bravado Labs Premium Histamine Block Supplement

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If you have histamine intolerance and in search of a good DAO supplement, then you can try using Bravado Labs Premium Histamine Block Supplement.

Pros

  • Bravado Labs histamine block helps increase DAO levels, which in turn helps break down histamines commonly found in high levels in alcohol, cheese, certain vegetables, shellfish, smoked meats, and other fermented foods.
  • With this small, 60-capsule bottle, you can add DAO whenever the occasion calls for it. Just take one capsule hours prior to consuming histamine-rich or DAO-blocking food or drink.
  • While other histamine blocking or DAO supplements may require you to take multiple capsules, our Bravado Labs formulation provides the antihistamine power you need with just one capsule.

Cons

  • It may not work for everyone as every individual's body reacts differently.
  • It may take a few days to see the results, so patience is required.
  • It's a bit expensive compared to other DAO supplements in the market.

This product has been in my use for a few weeks now, and I can surely testify that it has been of great help to my histamine intolerance. I don’t sneeze or have a runny nose or any other allergies that are common with those people who are allergic to histamine foods. It is convenient to take and I only have to take one capsule before consuming the histamine triggering food or beverage.

The product doesn’t contain any animal-derived ingredients or dairy and is also gluten-free and free from major food allergens with no GMO ingredients. It is also made in the USA, so this means that you can be assured of quality.

Finally, if you are interested in an effective DAO supplement that can help you reduce histamine intolerance side effects, Bravado Labs Premium Histamine Block Supplement should be given a try.


NATURDAOCOM LEGUMACTIVE

NATURDAOCOM LEGUMACTIVE

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If you’re in search for DAO supplement to help with histamine intolerance, then NATURDAOCOM LEGUMACTIVE is quite beneficial.

Pros

  • With 1,000,000 HDUs / 32,1mg of vegetable protein, it is the most powerful DAO enzyme you can get to reinforce your digestive system.
  • Suitable for vegans and best natural choice if you are going to take it for a long period of time along with your diet.
  • Fast availability tablets in human intestine tested by radiological test.

Cons

  • Avoid if allergic to any of the following ingredients: Cellulose (vegetable source), LEGUMACTIVE (Peas* Pisum Sativum, Lentils* Lens Culinaris), Hydroxypropylcellulose (vegetable source), Stearic Acid (vegetable source) and Silicon Dioxide (mineral).
  • Not recommended for people with eczema rashes.
  • Some users find the dosage too high.

We have been trying NATURDAOCOM LEGUMACTIVE for some time now and we realized we can digest much better. They take tablet form and we did not notice any undesired effects. We also acknowledge the fact that this product does not contain food colors as well as genetically modified organisms.

However, the high dosage might not be a good idea for all people depending on their status. We also observed that they product doesn’t clear rashes of eczema as some of the users described. In conclusion, NATURDAOCOM LEGUMACTIVE can be considered as an effective DAO supplement of natural origin for people with histamine intolerance.


Prodigy Life Premium Histamine Block Supplement

Prodigy Life Premium Histamine Block Supplement

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If you are in search of the best DAO supplement that can help address histamine intolerance, then, Prodigy Life Premium Histamine Block Supplement is a recommended option.

Pros

  • Helps maintain healthy digestion, immunity, and mood
  • Non-GMO, gluten-free, and vegan
  • Money-back guarantee

Cons

  • May not work for everyone
  • Some users may experience side effects
  • May not be effective for severe cases of histamine intolerance

Prodigy Life Premium Histamine Block Supplement is the one that we should have tested, and we are satisfied with the outcome. This supplement holds potent compounds to support digestion, immunity, and even mood in the body. It is also free from GMO, contains no gluten and is vegan which means that it can be used as a substitute for conventional health supplements. Also, the money-back guarantee offers a way of making the purchase safe, as the buyer can get their money back if they do not like the product.

Nevertheless, the reader must bear in mind that the supplement may not be effective in all cases. Some of the side effects reported include stomach upset or headache. Moreover, the supplement may not work effectively for individuals with serious histamine intolerance issues.

In summary, if you are seeking for a good DAO supplement for addressing histamine intolerance Prodigy Life Premium Histamine Block Supplement is a good choice to go for.


Omne Diem Histamine Digest DAO 20,000 HDU - 60 Caps

Omne Diem Histamine Digest DAO 20,000 HDU - 60 Caps

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If you are a histamine intolerance person then, Omne Diem Histamine Digest DAO 20,000 HDU – 60 Caps might be the answer to what you have been searching for.

Pros

  • An Effective Enzyme Solution to Histamine Intolerance and Imbalance.
  • Gluten-free, non-GMO, soy-free, non-dairy, food-grade Diamine Oxidase - with no artificial preservatives or sweeteners.
  • Helps to reduce the reactions of histamine intolerance such as flushing, runny nose, sneezing, and digestive issues.

Cons

  • May not work for everyone.
  • Some customers have reported that it made them feel sick.
  • It might be a bit expensive for some people.

We have tested Omne Diem Histamine Digest DAO 20,000 HDU – 60 Caps and this product helps in the alleviation of symptoms associated with histamine intolerance. It also does not contain any preservatives and it has no added sweeteners and is gluten free, GMO free, soy free and non dairy. It is very convenient to use and after using it our symptoms have improved a lot.

However, we know that it may not suit everyone and some of the customers who have used it have found themselves feeling nauseous. Moreover, one must note that the cost may be relatively high for some individuals.

In conclusion, it would be possible to recommend Omne Diem Histamine Digest DAO 20,000 HDU - 60 Caps for everyone who feels the manifestations of histamine intolerance and seeks for effective remedy.


VitaMonk Histamine Blocker

VitaMonk Histamine Blocker

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If you have issues related to histamine intolerance, we suggest you give VitaMonk Histamine Blocker a try.

Pros

  • Enjoy your favorite foods with confidence
  • Naturally minimize side effects
  • The only complete formula

Cons

  • May not work for everyone
  • Some users reported no major difference
  • May cause allergic reactions in rare cases

It should be noted that this supplement is aimed at histamine intolerance and contains several characteristic components. Thanks to the DAO enzymes, you might be able to consume some foods again one day. The Vitamin C and Bromelain are both antihistamines while Bromelain is an enzyme that has been clinically tested to help support a healthy inflammation response to histamine.

We understand that VitaMonk does not add any synthetics or fillers into their supplements, and we did not note any severe side reactions to this product. Indeed, several users said that it has been the first DAO supplement that they ever took and it has no severe side effects.

We also like that HistaResist also supports the reconstruction of the DAO production, which is responsible for the breakdown of histamine. If you fortify your diet with digestive enzymes, then you stand the best chance of with natural resistance.

Although this product may not be suitable for everyone we advice those with histamine intolerance to try it out. It has aided a lot of people and might be the factor that determines whether your immune system is up and ticking or it allows you to eat in peace.


Histazyme from Amy Myers - Diamine Oxidase Dao Enzyme Supplement Histamine Blocker to Support Healthy Digestion & Food Derived Histamine Intolerance - Dietary Supplement 60 Capsules - 2 Months Supply

Histazyme from Amy Myers - Diamine Oxidase Dao Enzyme Supplement Histamine Blocker to Support Healthy Digestion & Food Derived Histamine Intolerance - Dietary Supplement 60 Capsules - 2 Months Supply

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If you are facing histamine intolerance issues, Histazyme from Amy Myers can be the key to helping you deal with the problem.

Pros

  • Works like a charm to break down ingested dietary histamine
  • Supports a healthy immune and inflammatory response to ingested histamine
  • Clinically proven to break down food-derived histamine in the digestive tract

Cons

  • May not exert its histamine digesting effects systemically or throughout the body
  • More expensive than other DAO supplements on the market
  • Results may vary depending on the severity of your histamine intolerance

So, Amy Myers has developed Histazyme which we have consumed personally and it works by degrading the histamine present in the food consumed thus preventing the histamine accumulation and immune response in the body. It also helps to maintain an immune and inflammatory response to histamine, which is ingested, and may help with headaches, dizziness, flushing in the face, neuropathy, sinus issues, etc.

Further, Histazyme from Amy Myers is histamine-reducing compound in the gastrointestinal tract, which is clinically effective. This means that you can take it before meals to aid in digesting histamine in the gut, but it will not actively digest histamine systemically or throughout the body.

However, one should bear in mind that the effectiveness depends on the level of histamine intolerance. Amy Myers Histazyme may not work as well in those who have a really severe issue with histamine. It is also more costly than other DAO supplements that are available in the market.

All in all, if you have problems with histamine intolerance, we suggest you try Histazyme from Amy Myers. ‘It is approved and guaranteed by Dr. Amy Myers and it may be the answer you have been looking for to keep your symptoms in check and enhance your health.


Healthy Habits Living Histamine Manager

Healthy Habits Living Histamine Manager

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All in all, we highly suggest the Healthy Habits Living Histamine Manager to anyone who is experiencing histamine intolerance. This supplement is a godsend for people who complain of issues like gas, bloating, headaches, sinusitis, and food intolerance.

Pros

  • Contains 18,000 HDU per serving of the active enzyme Diamine Oxidase (DAO) responsible for neutralizing histamine in your digestive tract.
  • Allows you to enjoy histamine-releasing foods and red wine with ease and confidence.
  • Helps increase available DAO during digestion to alleviate histamine reactions.

Cons

  • May not manage or address antibody-related or IgE-related food allergies.
  • Some users may experience negative side effects such as headaches or stomach discomfort.
  • The recommended dosage may not be suitable for everyone.

The Healthy Habits Living Histamine Manager is an enzyme formula containing diamine oxidase (DAO) which has been clinically researched and developed to neutralize ingested histamine in the gastrointestinal tract. It does not contain gluten, GMOs, soy and dairy and it is free from preservatives and artificial sweeteners.

What we observed was that consuming 1-2 capsules up to 15 minutes prior to the consumption of meals or alcohol neutralized histamine reactions, propensity of having a headache, or the typical allergic reactions. It is most useful in consumption of foods containing histamine such as red wine.

Although many people with histamine intolerance may not experience significant improvement after following a low histamine diet, the Healthy Habits Living Histamine Manager aids to raise the concentration of DAO during digestion hence should be used alongside the low histamine diet.

All in all, we confidently recommend the Healthy Habits Living Histamine Manager to anyone seeking better histamine intolerance and freedom to eat and drink their favorite products without uncertainty.

Buying Guide

There are certain criteria you should follow when it comes to choosing the best DAO supplement for histamine intolerance.

Ingredient Quality

To begin with it is necessary to select a supplement that would contain a high quality active substance. Consciously choose products that are derived from natural non GMO sources and do not contain chemicals or preservatives. Also, decide on a supplement that has been tested by a third party for purity and potency of the product.

Dosage

The dosage of DAO supplements that is recommended may vary based on the particular brand and product involved. As with most treatments, be sure to read the label carefully and adhere strictly to the instructions given. Depending on the specific product, you may have to take numerous capsules throughout the day or just one.

Price

DAO supplements are not all the same when it comes to the cost, so you need to decide on which product is affordable to you. It is also important to note that more expensive products are not necessarily better, therefore it is always recommended to compare the prices and make sure to read the comments and reviews of other customers.

Allergens

If you are allergic to something or have a certain diet, it is always wise to check the label for such allergens. Some of the supplements contain elements such as soy, gluten, or dairy, which are allergens to some people.

Customer Reviews

Finally, one should also check references from consumers on the specific product before purchasing it. This can help provide more information on performance of the particular product and whether or not it would be profitable to invest in it. Focus on products with good reviews or a large number of positive feedback from people who used them.

Frequently Asked Questions

What are some effective supplements for managing histamine intolerance?

Some supplements that may be beneficial when histamine intolerance is present are DAO supplements, quercetin, vitamin C, as well as probiotics.

What should I look for when choosing a DAO supplement?

While selecting a DAO supplement, one has to go for the one that contains a pure source of DAO like that derived from porcine kidney. Also it is advisable to select a supplement without allergens and other unhealthy additives in it.

Are there any vegan DAO supplements available?

At the moment, there is no specific vegan DAO supplement available for purchase in the stores. However, there are other supplements that can be beneficial when it comes to histamine intolerance and these include quercetin and Vitamin C.

What are the symptoms of DAO deficiency?

Headache, migraines, fatigue, cognitive impairment, skin rash, gastrointestinal dysfunction, and various others are some of the signs of DAO deficiency. To determine whether you are suffering from histamine intolerance, you should consult a healthcare provider.

Can DAO supplements help alleviate histamine intolerance symptoms?

DAO supplements can help in the treatment of histamine intolerance especially when taken before meals that contain high histamine content. However, it is pertinent to understand that DAO supplements are not suitable for everyone and that they should be taken along with other lifestyle modifications like eliminating high-histamine foods.

When is the best time to take DAO supplements for histamine intolerance?

DAO supplements should be taken 15-30 minutes before meals containing histamine to work effectively against the intolerance. This means that the DAO can be available in the gut to neutralize histamine if it is consumed as a food component before the onset of symptoms.

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