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Top 7 Best Folate Supplements

UpdatedJuly 23, 2024

Folate is a B vitamin that plays a crucial role in the growth and development of cells in the human body. It is especially necessary for pregnant women since it can minimize the risk of malformations in the baby’s brain and spine. Folate is a B vitamin that is found in foods such as green leafy vegetables, beans, and citrus fruits; however, many people do not get enough folate in their diets. This is where folate supplements come in.

The different forms of folate supplements include folic acid, methylfolate, and folinic acid. Folic acid is the manufactured form of folate and is the most commonly used type of folate in supplements. Methylfolate and folinic acid are active forms of folate and are considered to be better absorbed in the body as compared to folic acid.

Top 3 Best Folate Supplements

  1. Thorne 5-MTHF 1mg
  2. Pure Encapsulations Folate 1000
  3. Jarrow Formulas Methyl Folate Veggie Caps

In order to provide you with the best folate supplement, we have done research and compared different available options on Amazon. We have highlighted the best folate supplements on the market today, based on its efficiency, reliability, and what users have to say about them. Here is a list of the Best Folate Supplements on Amazon and a buying guide to help you choose the right product.


Thorne 5-MTHF 1mg

Editor's Choice

Thorne 5-MTHF 1mg

Discover the champion's choice for folate: Thorne's 5-MTHF 1mg supplement. Trusted by 100+ pro teams and partnered with Mayo Clinic and 11 U.S. Olympic Teams, it's a standout in wellness. Experience easy effectiveness, from cardiovascular support to nerve health. Don't miss out!

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The Thorne 5-MTHF 1mg has been deemed best for anyone who is interested in a folate supplement that enhances the health of the heart, fetus, nerves, and metabolism of homocysteine.

Pros

  • Provides nutritional cofactors for optimal homocysteine metabolism, which supports cardiovascular health.
  • Supports healthy blood vessel and nerve function.
  • Contains active folate supplementation for healthy methylation.

Cons

  • Some users have reported issues with the safety seal on the bottle.

Thorne is a brand that has been chosen by champions and is used by more than 100 professional teams. This supplement is unique in partnering with Mayo Clinic in wellness research and editorial content. Furthermore, Thorne is a significant sponsor of eleven teams of the United States Olympic Committee.

Altogether, this supplement seemed to work well, and taking it was simple and convenient. We also liked the fact that it offered many types of positive effects such as the improvement of blood vessels and nerve health. Some users complain about the safety seal on the bottle but we didn’t face any problem with the bottle.

If you are therefore in need of a top notch folate supplement that is good for not just the heart but several other parts of the body, then you should consider ordering the Thorne 5-MTHF 1mg supplement.


Pure Encapsulations Folate 1000

Pure Encapsulations Folate 1000

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If you want a highly bioavailable folate supplement, then Pure Encapsulations Folate 1000 is a must try.

Pros

  • Provides the naturally occurring, universally metabolized form of folate
  • May provide significant cardiovascular, cellular, and neural support
  • Made with only premium ingredients sourced from trusted suppliers

Cons

  • Only contains 90 capsules, so you may need to reorder frequently
  • Some people may not like the unflavored taste
  • May be more expensive than other folate supplements on the market

For some time now we have been employing Pure Encapsulations Folate 1000 and the outcome has been quite favorable. It contains Metafolin, which is the naturally occurring and active form of folate called L-5-MTHF. This makes it easier for your body to take up and utilize which inturn would give better outcome.

Moreover, this Pure Encapsulations product, the Folate 1000, is made only from high quality active ingredients procured from known suppliers. This means that you can be assured that you are getting the best quality product which has not been adulterated with unwanted additives such as binders, fillers or preservatives.

Of course, when it comes to this supplement, there are some disadvantages also: for instance, the product contains only 90 capsules and can be pricey in comparison with the other similar products; yet we believe that it’s rather a good choice for those people who would like to take the high quality folate. All things considered, we’d definitely suggest that you give Pure Encapsulations Folate 1000 a go.


Jarrow Formulas Methyl Folate Veggie Caps

Jarrow Formulas Methyl Folate Veggie Caps

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We specifically recommend Jarrow Formulas Methyl Folate Veggie Caps as it delivers a highly potent and easily absorbed form of folate that benefits the cardiovascular and neurological systems and aids in DNA synthesis.

Pros

  • The product contains 1,000 mcg of methyl folate per capsule, known in its active form as methylfolate or (6S)-5-methyltetrahydrofolate.
  • It is non-GMO, gluten-free, vegan, and made with vegetarian-friendly ingredients.
  • Methyl folate is a highly biologically active form of folate.

Cons

  • Some people may experience dizziness after taking it.
  • The product is not available at most stores.
  • It may not be suitable for those who prefer synthetic folic acid.

In the past few weeks, we have been using Jarrow Formulas Methyl Folate Veggie Caps and we have felt much better since then. The capsules are easy to swallow and did not lead to any upset in my stomach. We understand that this product has fresh and natural ingredients and it does not contain any elements which trigger allergies.

For efficiency, we have established that there is enhanced energy and mood. We also understand that the product is safe for the heart and nerves and is essential in cell division. But, we did get dizzy after taking it, which may not be preferred by some persons who take it.

In conclusion, we fully endorse Jarrow Formulas Methyl Folate Veggie Caps for anyone in search of a highly effective, highly assimilable form of folate to maintain their health.


Life Extension Optimized Folate (L-Methylfolate)

Life Extension Optimized Folate (L-Methylfolate)

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We highly endorse the supplement Life Extension Optimized Folate for those people who seek a premium quality folate supplement that supports cardiovascular and cognitive functions.

Pros

  • Biologically active form of folate
  • Supports healthy homocysteine levels
  • Non-GMO, gluten-free, and vegetarian

Cons

  • May not be suitable for those with certain medical conditions
  • May interact with certain medications
  • Some users may experience mild side effects

Life Extension Optimized Folate is a supplement that we have been taking for several months now and there is a drastic difference in the way we feel. Active form of this folate is absorbed 7 times more than typical folic acid to support nitric oxide production for cardiovascular and brain health.

One of the things that we enjoy about this supplement is the fact that it is procured in its natural state from the highest quality of raw materials that deserves our bodies. It is also Free from GMOs, contains no gluten and is a Vegetarian product which allows it to be used in various forms of diets.

As far as side effects are concerned, this supplement does not seem to have any side effects, but for those with certain health conditions or those who are under certain medications, this supplement might not be very suitable for them. Like with most supplements, one should consult their doctor before using it to avoid negative side effects.

All together, the Life Extension Optimized Folate supplement is a great option for anyone in search of an effective folate supplement that boosts their cardiovascular and cognitive health.


Triquetra Health Organic Methyl Folate Supplement

Triquetra Health Organic Methyl Folate Supplement

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We recommend Triquetra Health Organic Methyl Folate Supplement for you if you are seeking a quality folate supplement with the methyl B12 cofactor. Due to the liquid sublingual form it is convenient to take and the natural berry taste which does not leave a bitter aftertaste.

Pros

  • Metabolically active 5-MTHF form for optimal absorption
  • Organic and non-GMO ingredients
  • Added methyl B12 cofactor for enhanced effectiveness

Cons

  • May not be suitable for those with certain medical conditions or taking certain medications
  • Some users may find the dropper difficult to use accurately
  • More expensive than some other folate supplements on the market

We have been using the Triquetra Health Organic Methyl Folate Supplement for several weeks and observe better mood and cognition. This form is rapidly absorbed from under the tongue and the inclusion of methyl B12 cofactor increases its efficiency.

The lack of genetically modified foods and pesticides makes it a healthy option; however, it could be rather problematic for individuals with specific diseases or people who take specific medications. Users may also experience some challenges in using the dropper since it may be challenging to drop the liquid accurately.

In conclusion, we recommend the Triquetra Health Organic Methyl Folate Supplement for people who want a high-quality folate supplement with extra features.


Doctor's Best Fully Active Folate with Quatrefolic NonGMO Vegan Gluten Free 400 mcg Veggie Caps, 90 Count

Doctor's Best Fully Active Folate with Quatrefolic NonGMO Vegan Gluten Free 400 mcg Veggie Caps, 90 Count

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If you are interested in a high-quality and effective folate supplement, you can always go with Doctor’s Best Fully Active Folate.

Pros

  • Provides MTHF, the most directly required form of folate for DNA regulation and other metabolic processes
  • Includes vitamin C for added stability
  • Gluten-free, non-GMO, and vegan

Cons

  • Exposure to heat or sunlight may lead to melting/damage of product
  • Label images may vary
  • During the summer months, products may arrive warm

For quite sometime now we have been using Doctor’s Best Fully Active Folate and it has been very handy in our daily supplements. The MTHF form of folate is actually the most directly needed for regulating DNA and other important metabolic processes, and we have indeed observed enhancement in our general well being, after taking it.

It is also important to note that this supplement is free from gluten, GMOs and is vegan which makes it ideal for all kinds of diets. However, it is always good to have that extra boost of vitamin C to help stabilize it as well.

It may be important to know that direct contact with heat or sunlight can cause the product to melt or otherwise deteriorate — just be careful when storing and using the product. We have also observed that the label images may differ but this does not in any way impact on supplement quality and efficacy.

Altogether, we suggest that anyone who is in the process of choosing a folate supplement should opt for Doctor’s Best Fully Active Folate without any hesitation.


Pure Encapsulations B12 Folate

Pure Encapsulations B12 Folate

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We recommend Pure Encapsulations B12 Folate supplement for individuals seeking for a superior quality and effective folate product for energy, brain and gut health.

Pros

  • The supplement contains Vitamin B12 and folate, which help convert carbohydrates into energy and break down proteins in the body, providing metabolism support.
  • The active form of the B12 vitamin, methylcobalamin, supports the nervous system and functions as hair, skin, and liver aids.
  • Folate is essential for fetal neural development, while B12 is an important nutrient for memory and cognitive support.

Cons

  • The supplement may be pricey for some users.
  • The recommended daily dosage may be too high for some individuals.
  • The supplement may not be suitable for those with certain allergies or dietary restrictions.

Now for several weeks we have been taking Pure Encapsulations B12 Folate supplement, and we can state that the concentration and physical stamina have improved. We also acknowledge that the supplement does not contain allergens, artificial or unwanted added substances, or Genetically Modified Organisms.

It is also easy to take the supplement down the throat, and we have not been having any side effects to the supplement. As a precaution, it is best to consume the supplement with food, to reduce any possible ill-effects on the stomach.

In summary, it can be concluded that the Pure Encapsulations B12 Folate is an excellent advanced folate supplement for energy, cognition, and intestinal health.

Buying Guide

In deciding which of them is the best folate supplement that one should take, there are certain qualities that should be put into consideration.

Form of Folate

There are two main forms of folate: Methylfolate and folic acid. Folic acid refers to the synthetic form of folate that is used in supplements or added to foods deliberately. Folinic acid, on the other hand, is the active form of folate that your body can use. If you have a genetic mutation that affects your ability to convert folic acid to methylfolate, you will need to search for a supplement that contains methylfolate.

Dosage

Folate for adults should be taken in a range of 400 to 600 micrograms per day. However, there are some populations that might require more, for instance, pregnant women or people with certain health issues. Be careful when selecting folate and always look at the dosage and the best product that you need.

Other Ingredients

It should be noted that not all folate supplements are the same, some may contain additional substances, for example, vitamin B12 or other B vitamins. Be very careful and make sure that you read the details so that you can get only the supplements with the right ingredients.

Quality and Purity

As with any supplement, it is crucial to select a product that is of good quality and does not include any impurities. Seek supplements with third party certifications for their purity, and select a brand of high quality that has good reviews.

In conclusion when selecting the best folate supplement one should consider the type/ form of folate, the amount/ dosage, other compounds, and the quality/ purity of the supplement. Considering these factors, you will be in a better position to make the right decision and go for the supplement of your choice.

Frequently Asked Questions

What is the difference between folic acid and folate?

Folic acid and folate are both B9 vitamins that are crucial for the body. Folic acid is the synthetic form of vitamin B9 used in food fortification and in supplements. Folate, on the other hand is the natural form of vitamin B9 which is derived from natural foods such as the green leaves, beans and fruits such as oranges. Although both are vital, there are those who have a problem with the conversion process of folic acid to folate thus preferring folate supplements.

What is the recommended dosage for methylfolate supplements?

The dosage of methylfolate supplements that may be suggested may differ depending on the patient’s requirements and health condition. However, it is recommended that one consult a healthcare provider to get the right dosage for him/her. However, normally the advised daily amount of folate is between 400 to 800 mcg for an adult population.

Are there any side effects to taking a folate supplement?

Folate supplement is safe when taken within the recommended dose. But the high doses of folate may lead to the side effects like nausea, bloating and stomach cramps. It’s recommended to stick to the recommended dosage indicated on the label and seek medical advice before taking them.

Which brand of methylfolate supplement is the most effective?

Methylfolate supplements are available in various brands, and one cannot compare the efficiency of one brand to another easily. But always ensure that you buy a branded product that has right combination of ingredients that have been proved to be absolutely pure and effective.

Can taking a folate supplement help prevent birth defects?

Folate is crucial in the development of the fetus and taking folate during this period can aid in preventing defects such as neural tube defects. Pregnant women should take between 600-800 micrograms of folic acid daily.

Is it safe to take a high dose of l-methylfolate for depression?

L-methylfolate is also prescribed in cases where the patient has a genetic anomaly that may hinder the absorption of folate and is used to treat depression. However, when administered in high doses, l-methylfolate can produce adverse effects such as irritability, insomnia and gastrointestinal disorders. One should consider seeking the help of a healthcare provider before taking any kind of supplements for depression.

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