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Top 6 Best SAMe Supplements

Written by Andrew Le, MD

UpdatedJuly 30, 2024

SAMe or S-adenosylmethionine is one of the compounds that are naturally produced in the human body. It affects many physiological functions, such as mood stabilizing, liver support, and joint health. It has been found that as people grow older, the body makes little or no SAMe, thus leading to deficiency. This lack could very well lead to mood disorders, liver complications and joint pains.

SAMe supplements raise the concentration of SAMe in the body since they are a natural source of the compound. They are found in tablet and capsule forms and powders as well. The factors to consider when selecting the best SAMe supplement includes purity, dosage, and form of the supplement available on the market.


Nutricost SAM-e (S-Adenosyl-L-Methionine) 400mg

Editor's Choice

Nutricost SAM-e (S-Adenosyl-L-Methionine) 400mg

Nutricost SAM-e offers 400 mg per serving in a vegetarian capsule, supporting mood, cognition, and joint health. Non-GMO and gluten-free, it meets high-quality standards for diverse dietary needs.

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When it comes to maintaining our mental and emotional well-being, Nutricost SAM-e (S-Adenosyl-L-Methionine) stands out as a top choice. With 400 mg per serving, this supplement provides a robust dose of SAM-e, renowned for its mood-supporting and joint-health benefits.

Pros

  • Each capsule contains 200 mg, and with 120 capsules per bottle, we get a generous supply for a significant period.
  • Perfect for those of us who are conscious about ingredient quality and dietary restrictions.
  • It fits various dietary preferences.

Cons

  • This supplement is slightly pricier compared to some other SAM-e options.
  • As with any supplement, results can vary. It may take some time to notice significant changes.

Nutricost SAM-e delivers a potent 400 mg per serving in a convenient vegetarian capsule. The formula is designed to support mood, cognitive function, and joint health. Being non-GMO and gluten-free ensures it meets high-quality standards, catering to various dietary needs.

Nutricost SAM-e has been shown to support joint comfort and emotional equilibrium. The 200 mg dosage per capsule is the best option for people who need a high dose without taking too many tablets. For individuals looking for consistent SAM-e advantages, the quality and efficacy make it a worthy investment, even though the price could be a little excessive. All things considered, it's one of the best supplements for SAM-e.


NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets 60 Count (Pack of 1)

NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets 60 Count (Pack of 1)

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NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg is highly recommended as it is proven effective and all natural.

Pros

  • Effective in alleviating aches and pains
  • Supports nervous system and emotional well-being
  • Enteric-coated for easy digestion

Cons

  • May cause mild stomach upset
  • Requires refrigeration after opening
  • May not be suitable for individuals with certain medical conditions

For minor aches and pains resulting from overexertion, we established that NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg was useful. Furthermore, it helps nourish the nervous system and emotions since it is particularly beneficial for mood elevation. The enteric-coating also helps enhance easy digestion and absorption of the nutrients contained in the product.

However, it is important to note that some people may develop adverse side effects, such as mild stomach upset when using this supplement. This also means that the product needs to be refrigerated after opening and is not advisable for consumption by persons with certain health conditions. Nonetheless, these are the possible drawbacks that should not deter anyone from using NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg since it is an excellent supplement for individuals who would want to have a great health boost.


Jarrow Formulas Same 200 mg

Jarrow Formulas Same 200 mg

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We confidently recommend Jarrow Formulas Same 200 mg as it is both a quality and price effective supplement that will enhance your health.

Pros

  • The biologically active form of SAMe is the S,S structure.
  • Supports joint health, liver function, brain metabolism, mood, and antioxidant defense.
  • Enteric-coated to ensure a biologically active product.

Cons

  • May cause nausea if taken on an empty stomach.
  • May cause stomach upset if taken in higher doses.
  • Some people may not see any noticeable effects.

Jarrow Formulas Same 200 mg is a much better supplement that contains 6 well defined probiotic strains. It is free from any of the major food allergens and is dairy and gluten-free as well as vegetarian. ”It is hypoallergenic and certified non-GMO by NSF.

SAMe facilitates connective tissue metabolism and the synthesis of Glutathione, which is essential for protection against oxidation and liver functioning. SAMe-dependent methylation reactions have been related to the formation of phosphatidylcholine and other neurotransmitters like dopamine, norepinephrine, and serotonin. The given formula has been proven to improve mood.

Regarding the use of Jarrow Formulas Same 200 mg, we established that it is easy to swallow and improves our overall health condition. It is enteric coated to contain a biologically active compound, which is a good thing. However, one side effect noted was nausea when the drug was consumed on an empty stomach and some stomach grumbles when taking large volumes of the drug.

In conclusion, Jarrow Formulas Same 200 mg is one of the recommended supplements for those who want to have healthy joints, liver and brain metabolism, mood, and antioxidant levels. This is a cheap method that is effective and recommended since it is made from quality raw materials.


Life Extension Same 400mg

Life Extension Same 400mg

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People seeking supplements that can be useful for joint and liver support should consider using Life Extension Same 400mg.

Pros

  • SAMe is a compound that occurs naturally in your body and helps regulate hormones and maintains cellular membrane health.
  • Life Extension Same 400mg is formulated with an enteric-coated tablet to bypass the stomach’s harsh environment so that it’s easier for your body to absorb.
  • This product is certified non-GMO and gluten-free and sourced using only the finest raw ingredients.

Cons

  • Exposure to heat or sunlight may lead to melting/damage of the product.
  • The tablets are relatively large, which may be difficult for some people to swallow.
  • Some customers have reported that the product is not effective for them.

In our experience, Life Extension Same 400 mg has proven useful in maintaining healthy joints and the liver. It is good to know that the product is non-GMO and Gluten-Free, and it is formulated in an enteric-coated tablet for better absorption.

However, we would like to inform customers that the product can melt or sustain some damage if exposed to heat or Sunlight. Also, the tablets are relatively large making it difficult for some individuals to actually swallow the whole of it.

In conclusion, we would like to claim that Life Extension Same 400mg is a rather decent supplement to turn to if one’s goal is to improve the state of their joints and liver.


OjosLabs SAM-e 500mg 60 Capsules

OjosLabs SAM-e 500mg 60 Capsules

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We recommend the OjosLabs brand of SAM-e supplement for those who want to take something for the liver and mood that has been proven to be safe and effective.

Pros

  • Developed for easy absorption
  • Made with pure, premium ingredients
  • Made in the USA

Cons

  • Some users may experience a bad smell from the capsules
  • May not work as effectively as other brands for some individuals
  • Results may take time to notice

We observed that taking the OjosLabs SAM-e supplement was quite straightforward and offered improvements in liver performance and mood. The supplement is produced using quality ingredients and is produced in the United States of America, therefore meeting the deserved quality.

Another notable characteristic of this supplement is its easy digestibility. What we observed was that the supplement was very well assimilated without any issues of stomach upset. Also, it is made of only natural and top-notch ingredients, which makes us trust the supplement.

We had no problems with the supplement but some people may find the capsules to have a bad smell. Besides, it can be seen that some people may not derive the same benefits they would get from the other brands. But all the same we still feel that the OjosLabs SAM-e supplement is a good option for anyone interested in liver support and mood boost.

Thus, we believe that the OjosLabs SAM-e supplement is one of the best options for people interested in using a trusted and efficient product for liver and mood enhancement. Due to its digestibility and quality of ingredients, which is complemented by its effectiveness, it is an excellent supplement for everyone.


DR EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e for Mood, Stress, and Sleep

DR EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e for Mood, Stress, and Sleep

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For a natural product that can help you maintain a relaxing mood, the DR EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e for Mood, Stress and Sleep is ideal.

Pros

  • The supplement can support mood and rest.
  • Vitamin B6 helps improve 5-HTP conversion.
  • May promote calm and relaxation.

Cons

  • The smell of the capsules can be unpleasant.
  • It can take a while for the supplement to start working.
  • Some people may not notice any effects.

We've been taking DR EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e for Mood, Stress, and Sleep for some time now, and we have noticed that it makes them relaxed with less stress. It is a doctor-formulated product manufactured in the USA, which makes us believe that the supplement is of the best quality.

Another advantage of this supplement is that it contains vitamin B6 which is known to facilitate 5-HTP conversion. This means that the supplement is better than other 5-HTP supplements that do not contain vitamin B6. We have also noted that the supplement is easy to take and we did not note any side effects.

However, we have realized that this comes with a downside since the smell of the capsules is rather unpleasant. Also, the effects of the supplement may not be immediately seen, so one has to be patient and make sure they stick to the correct dosage. Finally, it can be observed that some people do not experience any changes at all, which should be taken into consideration when it comes to trying the product.

In conclusion, we suggest that anybody who is in search of a natural remedy to support a relaxed mood, stress, and sleep try DR EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e.

Buying Guide

To find the right SAMe supplement, the following factors should be considered.

Form and Dosage

The available SAMe products include tablets, capsules, and powders. The choice of the form should be one you take frequently and is ideal for your requirements. Also, the dosage may differ from one product to another and, therefore, it is necessary to use a product that suits the required dosage.

Purity and Quality

Another crucial consideration is the purity and quality of the selected SAMe supplement. Choose products from reliable manufacturers and ensure that they have been checked for quality and strength. However, some of these products have other ingredients or additives, so make sure you check the label.

Price

SAMe supplements can also be expensive or cheap depending on what brand you want to go with. Of course, it is always possible to find a cheaper version of a certain product, but in this case, it is necessary to remember that the quality of the goods should be a priority.

Customer Reviews

One way to determine if a SAMe supplement is effective is to read the reviews provided by customers. It is recommended that you find products that have been used by other customers with similar requirements as you have.

Frequently Asked Questions

What is the supplement SAM-e good for?

SAM-e supplement is used in the management of depression, osteoarthritis and liver diseases. SAM-e is a substance naturally occurring in the body and plays an essential role in hormone and neurotransmitter synthesis.

Do SAM-e supplements work?

Some data indicate that SAM-e supplements might be beneficial for depression and osteoarthritis, although further research is required. SAM-e may also be useful for the treatment of liver diseases but there is a lack of sufficient evidence to support this.

How long does it take for SAM-e to kick in?

It has been established that the effectiveness of SAM-e supplements may only manifest after some weeks, and therefore, these supplements should be consumed as recommended. Before taking SAM-e supplements it is advised to contact a healthcare provider.

What are the benefits of SAM-e supplements?

Some of the possible positive effects of SAM-e supplements include mood enhancing, anti-inflammatory properties and liver support. However, further studies are required to establish the above mentioned advantages.

What are the recommended dosages for SAM-e supplements?

The dosage of the SAM-e supplements to be used depends on the condition that is being treated. One has to administer the product as instructed on the label or prescribed by the doctor or pharmacist.

What is the best way to take SAM-e supplements?

SAM-e supplements are consumed in capsule or tablet form and is best absorbed if taken on an empty stomach. It is recommended to consult a doctor before incorporating SAM-e supplements into one's diet to understand the appropriate dosage to take and how to go about it.

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