Skip to main content

Top 7 Best Serotonin Supplements

Written by Andrew Le, MD

UpdatedAugust 5, 2024

Serotonin is an essential neurotransmitter that is involved in the modulation of mood, appetite and sleep cycle. These include depression, anxiety and other mental health disorders, which can be caused by low levels of serotonin. Though there are drugs like SSRIs that can help in increasing the serotonin levels in body, some individuals prefer to go for natural ways of increasing serotonin. This is where serotonin supplements come into play.

Serotonin supplements are the dietary supplements that are made up of the ingredients that are believed to enhance the levels of serotonin in the brain. Such supplements usually have amino acids, including tryptophan and 5-HTP, which are precursors of serotonin. Other natural substances that boost serotonin production include St john’s Wort and Saffron.

Top 3 Best Serotonin Supplements

  1. Double Wood’s L-Serine Capsules
  2. Natural Stacks Serotonin w/L Tryptophan & Rhodiola
  3. Dr. Maxwell Serotonin and Dopamine Supplements

To help you find the best serotonin supplements, we have researched and tried several products on Amazon. Serotonin is a hormone that is involved in the management of mood, hunger and even sleep. It is also known as the feel good hormone and lack of serotonin is associated with depression, anxiety and other related illnesses. If you are interested in enhancing the levels of serotonin in your body, then the following supplements might be helpful to you. Here are our recommendations for the top serotonin supplements you can get on Amazon.


Double Wood’s L-Serine Capsules

Editor's Choice

Double Wood’s L-Serine Capsules

Double Wood’s L-Serine Capsules offer 500 mg of high-quality, third-party tested L-Serine, supporting serotonin production and brain health. With 180 capsules per bottle, they're cost-effective and potent. We noticed improved mood and clarity quickly, despite minor initial stomach discomfort. Overall, a top choice for serotonin supplements.

See Price on Amazon

We have been trying to find good supplements that would increase serotonin level within the brain. With high specifications and clinical support, Double Wood’s L-Serine Capsules stood out among the best serotonin supplements. This product delivers a conveniently packaged and potentially powerful 2,000 mg serving that was employed in clinical trials.

Pros

  • Third-party tested for purity and potency.
  • Promotes serotonin production and brain support.
  • 180 capsules provide a long-term supply.
  • Backed by clinical studies.

Cons

  • Capsules might be large for some to swallow.
  • Not suitable for vegans (gelatin capsules).
  • Potential mild digestive discomfort for sensitive individuals.

The L-Serine Capsules of Double Wood contain 500 mg of L-Serine in a capsule, thus offering a maximum strength dosage for the best outcome. It is a third-party tested supplement, which ensures that the supplement is actually of high quality and free from adulteration. The 2,000mg serving as applied in the clinical research proves its veracity and ensures us of its efficacy. As each bottle contains 180 capsules, it is cheaper and more accessible in the long run if one is to use it frequently. L-Serine is an amino acid that aids in the manufacturing of serotonin and overall brain, thus recommended for consumers who want to improve their mental performance and mood.

After weekly usage, we found a marked change in our mood and coherence of mind within a few weeks. Since each capsule had a high potency, we did not have to consume several pills every day. Regardless of their size, the capsules were easy to integrate into our daily lives. The third-party testing issue gave confidence in the safety and effectiveness of the product. The only complaint that we have is that for the first couple of days, our stomachs were a little off; however, it passed quickly. In conclusion, Double Wood’s L-Serine Capsules did not disappoint, which placed them among the top serotonin supplements that we have used.


Natural Stacks Serotonin w/L Tryptophan & Rhodiola

Natural Stacks Serotonin w/L Tryptophan & Rhodiola

See Price on Amazon

All in all, if you want to get a genuine and powerful mood support supplement, then the Natural Stacks Serotonin w/L Tryptophan & Rhodiola is just what the doctor ordered. This is a non addictive supplement that happens to be plant based, and is likely to boost positivity, elevate mood, and even enhance health.

Pros

  • The supplement works within minutes and can help you feel happy, calm, and clear.
  • It contains high-quality Rhodiola Rosea, L Tryptophan, Vitamin B3, Magnesium, and Zinc, all of which are essential nutrients for making more of the "happy molecule."
  • The supplement is non-GMO, gluten-free, and paleo-friendly, making it great for most diet types and special lifestyles.

Cons

  • The supplement may not work for everyone and may take some time to show noticeable effects.
  • Some users may experience mild side effects such as headaches, dizziness, or upset stomach.
  • The supplement may interact with certain medications, so it's important to consult with a healthcare professional before taking it.

I have experimented with this supplement myself and it made me feel more energetic and willing to tackle the day’s activities. The Rhodiola Rosea capsules, which are an adaptogenic herb, and one of the ingredients in this supplement did help in reducing physical and mental tiredness and avoiding burnouts.

Given that the formula contains the exact concentrations of each component as suggested by the research study, it is a potent and natural mood support supplement. We also want to acknowledge that Natural Stacks is an open source company that guarantees the origin of the ingredients, the third-party lab testing, and the full disclosure of labels for the supplements.

In conclusion, if you are seeking for the natural solution that may help you improve your mood and boost your health, then it will be worthy to try the Natural Stacks Serotonin w/L Tryptophan & Rhodiola supplement.


Dr. Maxwell Serotonin and Dopamine Supplements

Dr. Maxwell Serotonin and Dopamine Supplements

See price on Amazon

For those who want to support their normal neurotransmitter levels and their health in general, we give our strong recommendation to use the Dr. Maxwell Serotonin and Dopamine Supplements.

Pros

  • The formula contains precursors of both dopamine and serotonin, making it better than taking a supplement to support only dopamine or only serotonin.
  • Provides mood support and relaxation with Magnesium and Vitamin D3.
  • Contains Ashwagandha, L-theanine and Taurine to support daily cognitive function and mental tasks.

Cons

  • Some users may experience stomach discomfort.
  • The product label includes a DO NOT USE section, which should be checked before use.
  • The product may not be suitable for those with certain allergies.

We have been using the Dr. Maxwell Serotonin and Dopamine Supplements for some time now and have observed an improvement in my mood and focus. It has the precursors for dopamine and serotonin which are far better than taking a supplement just to help enhance one neurotransmitter alone. The mood support and relaxation offered to us by Magnesium and Vitamin D3 have also been helpful to us.

Nonetheless, the supplement may cause stomach issues in some users, and one has to look at the DO NOT USE list in the label before taking the product. Also, it should be remembered that the product may be contraindicated for the use of those people who have certain allergies.

In conclusion, everyone interested in the support of the neurotransmitter levels and well-being, should try the Dr. Maxwell Serotonin and Dopamine Supplements.


TWINLEAF Serotonin Supplement

TWINLEAF Serotonin Supplement

See price on Amazon

If you’re looking for a supplement that can help improve your mood and wellbeing, we highly suggest the TWINLEAF Serotonin Supplement.

Pros

  • The unique combination of ingredients, including 5-HTP, GABA, L-Theanine, L-Tryptophan, and a herbal blend, make for a powerful serotonin booster.
  • The capsules are vegan, non-GMO, and made in the USA, ensuring high quality and safety.
  • TWINLEAF offers a Positive Experience Guarantee, so you can try the product risk-free.

Cons

  • The capsules are quite large, which may be difficult for some people to swallow.
  • The effects may not be noticeable immediately and may take some time to build up in the system.
  • The product may interact with certain medications, so it's important to consult with a healthcare provider before use.

For the past few weeks, we have been using the TWINLEAF Serotonin Supplement and we have seen a great improvement in our moods and well-being. It is made up of natural ingredients such as 5-HTP and GABA that are useful in easing stress and anxiety hence enhancing relaxation. We also like that the capsules are vegan and non-GMO and manufactured in the USA to guarantee their quality.

Even though the capsules are relatively large, we were not faced with any problem of swallowing them. However, it should be noted that the results of using the supplement may not be seen at once and may take some time to show in the body. Also, it is recommended to seek advice from a doctor before using the product because it can have interactions with medications.

All in all TWINLEAF Serotonin Supplement is highly recommended for people who want to enhance their mood and health naturally.


5HTP Liquid Drops

5HTP Liquid Drops

See price on Amazon

If you are interested in buying a serotonin supplement that is proven to be effective and fast acting, we highly recommend that you buy 5HTP Liquid Drops.

Pros

  • The 50mg dose of 5 HTP drops is far more noticeable than encapsulated 5 HTP products.
  • Double Wood offers the first ever maximum absorption 5 HTP drops that are over 99% 5-HTP.
  • The 60 servings of our 5 HTP supplement per bottle in a convenient dropped format provides a two month supply.

Cons

  • The glycerin drop flavor may not be suitable for everyone.
  • It may take time to get used to the taste and texture.
  • It may not work for everyone.

We have been using 5HTP Liquid Drops for a few weeks now and have seen wonderful changes in our mood and sleeping patterns. The 5-HTP as a product is a great supplement to serotonin since these drops are highly absorbable and potent.

The dropped format is very convenient to take and the two month supply is a good value. Nevertheless, the glycerin drop flavor and texture may not appeal to everyone and it may take a while to adapt to it.

In conclusion, we recommend 5HTP Liquid Drops to anyone seeking a trustworthy serotonin supplement.


BRAINMD Serotonin Mood Support

BRAINMD Serotonin Mood Support

See price on Amazon

For a natural product that aims to support serotonin levels, it is advisable to opt for BRAINMD Serotonin Mood Support.

Pros

  • Helps balance and produce serotonin, the natural brain chemical and regulator
  • Promotes a clear mind and more energy
  • Helps control appetite and minimize emotional overeating

Cons

  • May not work for everyone
  • Some users may experience side effects
  • May take time to see results

We have personally tested BRAINMD Serotonin Mood Support and feel that it made us more optimistic and energetic. The innovative blend of patented saffron extract, 5-HTP, Vitamin B12, Vitamin B6, and Vitamin Folate helps to maintain the serotonin levels.

Of all the features that we love about this product, quality and purity of the product stand out. BRAINMD’s products are all formulated by doctors and produced in FDA-registered facilities, which means the supplement is of good quality.

BRAINMD Serotonin Mood Support may not have favorable effects for all users, but we think it is worth it to give it a try if one wants to supplement serotonin naturally. As long as one sticks to the recommended dosage and discusses with the doctor before introducing the supplements, then the supplements are very beneficial.

In conclusion, for those who want to add natural mood support, energy, and appetite regulation into their lifestyle, BRAINMD Serotonin Mood Support is worth a shot.


NATURAL STACKS Serotonin w/L Tryptophan & Rholiola - Mood Support & Serotonin Supplement - Promotes Positive Mood, Calmness, Increased Energy - Happy Mood & Brain Support Supplement (120ct)

NATURAL STACKS Serotonin w/L Tryptophan & Rholiola - Mood Support & Serotonin Supplement - Promotes Positive Mood, Calmness, Increased Energy - Happy Mood & Brain Support Supplement (120ct)

See price on Amazon

If you want to feel happier and more motivated, you should definitely try NATURAL STACKS Serotonin w/L Tryptophan & Rholiola.

Pros

  • This supplement can help you feel happier and more positive within minutes.
  • It can also increase your energy levels and motivation.
  • NATURAL STACKS Serotonin w/L Tryptophan & Rholiola is made with high-quality, natural ingredients.

Cons

  • Some people may experience side effects such as nausea or headaches.
  • The supplement may not work for everyone.
  • It may take some time to see noticeable results.

NATURAL STACKS Serotonin w/L Tryptophan & Rholiola is a powerful and natural mood support supplement that has been designed to improve your mood and make you feel happier, less stressed, and more focused. It has a combination of nutrients that are important in enhancing serotonin production in your brain which include Rhodiola Rosea, L Tryptophan, Vitamin B3, Magnesium and Zinc. This neurotransmitter controls mood, appetite, and sleep among other activities in the body.

It also contains Rhodiola Rosea, a natural adaptogen known to minimize exhaustion and fatigue and prevent mental and physical burnout. This key ingredient can assist you in being more productive and motivated during your working hours.

The distinctive aspect of NATURAL STACKS Serotonin w/L Tryptophan & Rholiola compared to other mood support supplements is its candor and product quality. The company is also an open-source one, which implies that it is ready to provide information about the origin of the ingredients, independent tests, and full-label declaration of the supplements.

All in all, if you’re in need of a natural supplement that can help improve your mood and energy, you should try NATURAL STACKS Serotonin w/L Tryptophan & Rholiola.

Buying Guide

To choose the serotonin supplement, there are certain important aspects that one has to take into consideration.

Ingredients

When selecting a serotonin supplement, one of the first things that should capture your attention is the components of the product in question. The products should contain ingredients that are known to increase serotonin concentrations in the brain, including 5-HTP, tryptophan, magnesium and others. Do not buy products containing additives such as artificial coloring and flavoring.

Dosage

The dose of the supplement is also important. Make sure that the products you find gives the safe and effective amounts of the active ingredients. The product must be consumed in a prescribed quantity that is stated on the label and not more than that quantity.

Quality

Another factor is the quality of the supplement that is to be taken. Buy from known brands and ensure that the products have undergone third-party testing for quality and for the presence of the necessary active ingredients. It is also possible to verify for GMP or third-party certifications of the company.

Form

Some of the preparations available in the market are capsules, tablets, powders and solutions. Therefore, choose the form that will be convenient for you to take and match your lifestyle.

Price

Another factor to look for in a serotonin product is the price. Strive to differentiate between products that represents good value for the amount of money you are willing to spend. But you must be very cautious when you come across products that are cheaper than other products since they may be counterfeit.

In conclusion, the consumption of the serotonin supplement should include natural compounds, cover a safe and effective dose of serotonin, be highly quality, available in a convenient form and cost an appropriate amount of money.

Frequently Asked Questions

What are some natural supplements that can boost serotonin levels?

There are several natural foods or supplements that will help to boost serotonin levels in the human body. Among the most noteworthy ones are omega-3 fatty acids, vitamin D, magnesium, and tryptophan. These supplements are effective in the sense that they help the body to possess the necessary nutrients for the production of serotonin.

How can I increase my serotonin levels quickly?

There are some ways that can help to raise the level of serotonin in the body rather fast. Some of these methods include exercising, exposing your skin to direct sunlight, and taking foods that contain tryptophan. Also, if a person wants to boost serotonin levels rapidly, they can always take a serotonin supplement.

Are serotonin supplements safe to take?

Taking serotonin supplements is quite harmless, however, there are certain precautions that should be taken, especially when a person decided to start a new supplement course. There are cases when side effects may occur or the medicine may interact with other prescribed drugs, so other precautions need to be taken in consultation with a health care provider.

What are the potential side effects of serotonin supplements?

Possible side effects of serotonin supplements are as follows: stomach upsets such as nausea, and diarrhoea, headaches, dizziness. Some of the side effects are minor and fade on their own but should be discussed with a healthcare provider if they do not subside or worsen.

What is the best way to increase serotonin without drugs?

The natural methods of boosting serotonin levels are through lifestyle alterations. Some methods may include engaging in physical activity, taking healthy foods, getting adequate rest, engaging in stress management activities for example, meditation, and yoga.

Is there a proven supplement that can increase serotonin levels?

Some of the supplements that were established to help in boosting serotonin levels include; omega-3 fatty acids, vitamin D, magnesium, and tryptophan. Nevertheless, precautions should be taken when taking any new supplements and therefore one should consult a doctor before he/she starts taking any supplements.

Affiliate Disclosure:
The links provided may earn us a small commission at no additional cost to you if you choose to purchase the recommended product. This support allows our research and editorial team to continue providing high-quality recommendations. As a participant in the Amazon Services LLC Associates Program, an affiliate advertising initiative, we are able to earn advertising fees through providing links to products on Amazon.com. Please rest assured that we only recommend high-quality products.