Does Ozempic Make You Tired? Understanding and Managing Fatigue Symptoms

Ozempic (semaglutide), a widely prescribed medication for managing type 2 diabetes, has garnered attention for its benefits. According to a health economy report, nine million prescriptions for Ozempic, Wegovy, and similar obesity drugs were written by US healthcare providers during the last three months of 2022.

However, alongside its promising effects, the prevalence of side effects experienced by users is notable. Among these, fatigue emerges as one of the most discussed side effects.

Understanding the factors contributing to fatigue in Ozempic users is essential for optimizing treatment outcomes and ensuring the patient’s well-being. This article will look into these factors, shedding light on potential strategies for effectively managing this side effect.

Does Ozempic Make You Tired?

Yes, Ozempic has the potential to induce fatigue, as indicated in the official prescribing information from the manufacturer. Clinical studies found that a small number of people taking Ozempic felt tired, with more than 0.4% experiencing this. However, the reason behind this occurrence is not fully understood.

Factors Contributing to Fatigue

Further research is necessary to understand how Ozempic influences feelings of tiredness. Individuals may eventually experience increased energy and reduced fatigue due to weight loss, improved cardiovascular health, and lifestyle changes.

Meanwhile, here are some explanations why Ozempic might induce fatigue:

1. Gastrointestinal (GI) Side Effects

The primary adverse effects of Ozempic typically involve vomiting (occurring in 5% to 9% of individuals), diarrhea (8%), stomach discomfort (6% to 7%), and constipation (3% to 7%). An expert pointed out that gastrointestinal side effects could result in dehydration, which might make someone feel tired.

When an individual experiences GI issues, the body expels significant amounts of fluids, leading to a rapid loss of hydration. When dehydration occurs, several physiological changes take place in the body, contributing to feelings of fatigue.

Dehydration leads to decreased blood pressure, impairing circulation and reducing blood flow to the brain. As a result, individuals may experience sensations of sleepiness due to the reduced delivery of oxygen and nutrients to brain cells.

Moreover, dehydration causes reduced blood fluid volume, requiring the heart to work harder to pump oxygen and nutrients. The increased workload on the heart can induce a state of fatigue as the body struggles to meet its metabolic demands efficiently.

2. Fluctuations In Blood Sugar Levels

The probability of low blood sugar (hypoglycemia) is typically low, but it remains possible. Individuals may face a higher risk of this side effect if they are also using other diabetes medications, such as sulfonylureas or insulin.

In 30-week trials with Ozempic as the sole diabetes treatment, individuals experienced symptomatic low blood sugar at rates of 1.6% to 3.8%.

When blood sugar levels decrease excessively, the body may not have sufficient glucose (sugar) to provide energy to cells, including those in the brain and muscles. This can result in symptoms like fatigue, shakiness, and confusion.

In response to hypoglycemia, the body may release stress hormones like adrenaline, which can further contribute to feelings of tiredness or exhaustion after the initial symptoms have passed.

On the other hand, when blood sugar levels are consistently high, the body's cells may develop insulin resistance, the hormone tasked with transporting glucose from the blood into body cells for energy use.

As a result, glucose remains in the bloodstream instead of being utilized by cells for energy production. This can lead to fatigue or tiredness because the body's cells do not receive the energy needed to function optimally. Additionally, hyperglycemia can cause dehydration as the body tries to eliminate excess glucose through increased urination, further contributing to fatigue.

3. Gastroparesis (Delayed Gastric Emptying)

Ozempic can reduce the speed at which food moves through the gastrointestinal (GI) tract, a condition known as delayed gastric emptying. This can cause gastroparesis, where the stomach's motility is impaired, resulting in symptoms like fullness, bloating, nausea, and vomiting.

These symptoms can disrupt normal eating patterns and nutrient absorption, potentially leading to nutritional deficiencies and energy depletion, which can manifest as fatigue. In a study of 156 gastroparesis patients, fatigue was prevalent in 93% of cases, with over half reporting severe fatigue.

However, it’s important to note that additional data is needed to ascertain whether Ozempic triggers gastroparesis or worsens preexisting conditions. Typically, the occurrence of gastroparesis in individuals with type 2 diabetes is approximately 1%.

4. Poor Quality of Sleep

Ozempic can potentially influence sleep patterns, either directly or through its associated side effects and behavioral alterations. Ozempic also has the potential to worsen anxiety and depression, conditions known to disrupt sleep quality. This creates a cyclical relationship, as disrupted sleep can further worsen anxiety and depression symptoms.

The FDA Adverse Event Reporting System (FAERS) has collected at least 489 reports of patients experiencing feelings of anxiety, depression, or suicidal thoughts while using Ozempic.

Moreover, a clinical trial company examined sleep-related issues among individuals taking Ozempic. It noted reports of poor sleep quality, particularly among female individuals aged 60 and above who had been using the medication for 6 to 12 months.

However, due to limited data availability and the absence of a standardized definition for sleep quality, the precise impact of Ozempic on sleep remains uncertain.

5. Decreased Calorie Consumption

Calories are the body's primary energy source. When calorie intake is not enough to meet the body's energy requirements, it can result in an energy deficit. This deficit deprives cells and tissues of the fuel they require to function optimally, leading to feelings of fatigue and lethargy.

In a 12-week study involving 30 obese individuals, semaglutide significantly reduced ad libitum energy intake compared to placebo, resulting in a 24% reduction in total daily energy intake.

Having explored the potential reasons behind fatigue induced by Ozempic, it's crucial to address how to effectively manage these symptoms. Let's explore practical approaches to alleviate fatigue symptoms and optimize health outcomes.

How to Manage Fatigue Symptoms When Taking Ozempic

Fatigue can present a challenge for individuals using Ozempic, but there are various strategies available to help manage these symptoms effectively. Here's a comprehensive guide to assist individuals in combating fatigue and improving their overall well-being:

Maintain a Balanced Diet & Regular Physical Activity

Despite changes in appetite, it's crucial to focus on maintaining a balanced diet for optimal health and sustained energy levels. Include nutrient-dense foods like fruits, vegetables, and lean proteins. Additionally, staying hydrated throughout the day supports bodily functions.

Engaging in regular exercise can enhance energy levels and promote better sleep quality. Aim for moderate exercise most days of the week, such as walking or yoga.

Improve Sleeping Habits

Getting the right amount of sleep can significantly impact energy levels. To achieve this, it's important to consider the following strategies:

• Stick to a regular sleep schedule.
• Eat meals consistently (dinner should not be too close to bedtime).
• Get at least 10 minutes of natural light in the morning.
• Avoid blue and green light before bed, including computers, smartphones, or tablets, as these devices can neutralize melatonin’s effects.
• Make your sleep environment comfortable and quiet.

Manage Gastrointestinal (GI) Issues

Addressing GI issues can alleviate symptoms contributing to fatigue. Opt for easily digestible foods to soothe the digestive system and ensure adequate hydration to prevent dehydration.

Reevaluation of Dosage

One of the first steps in addressing long-term fatigue while on Ozempic is to reassess the dosage. Healthcare providers may recommend adjusting the dosage or exploring alternative treatment options to alleviate fatigue while managing diabetes effectively.

Assess Comorbid Conditions

Health issues such as thyroid disorders or vitamin deficiencies can contribute to fatigue and may need to be addressed separately. Healthcare providers can conduct thorough evaluations and recommend appropriate treatments to address any underlying health issues contributing to fatigue.

Prioritize Mental Health

Factors such as stress, anxiety, or depression can worsen feelings of tiredness and make it challenging to cope with daily activities. Taking steps to prioritize mental health is vital for managing long-term fatigue while on Ozempic. Consider the following strategies:

• Reach out to friends, family members, or mental health professionals for support and guidance.
• Participate in stress-reducing activities, such as meditation, deep breathing exercises, or yoga.
• Make time for activities that bring joy.

Coping with fatigue while on Ozempic requires a multifaceted approach. Working closely with a healthcare provider for personalized advice is recommended to address individual needs and circumstances.

Final Thoughts

Ozempic, while effective in managing type 2 diabetes, presents potential challenges for users. This article explored several factors contributing to fatigue, including gastrointestinal side effects, fluctuations in blood sugar levels, delayed gastric emptying, and impacts on sleep quality.

Individuals can adopt a proactive approach to alleviate fatigue and improve treatment outcomes. This involves addressing gastrointestinal symptoms, maintaining a balanced diet, exercising, and fostering healthy sleep habits.

Also, open communication with healthcare providers can facilitate early detection and management of fatigue-related issues. Personalized care plans tailored to individual patient needs are essential for navigating the challenges of fatigue while maximizing the benefits of Ozempic therapy.

Does everyone experience fatigue on Ozempic?

Not everyone experiences fatigue while taking Ozempic.

How long does fatigue from Ozempic last?

Fatigue experienced as a side effect of Ozempic typically diminishes over time as your body adjusts to the medication. For most people, fatigue tends to improve within a few weeks to a few months after starting treatment. If fatigue persists or becomes severe, consulting a healthcare provider is advisable.

How can I differentiate between fatigue and normal tiredness?

Fatigue is typically characterized by persistent feelings of extreme tiredness or lack of energy that interfere with daily activities. On the other hand, normal tiredness is often temporary and can be relieved with rest or relaxation. Consult your healthcare provider for guidance if you're unsure about your symptoms.

Does Ozempic promote weight loss as a side effect?

Yes, weight loss is a common side effect of Ozempic use. Studies indicate that people who used Ozempic experienced a weight reduction exceeding 10% of their body weight over the course of one year. However, individual results may vary.

Does Ozempic cause headaches?

Yes, headaches can occur as a side effect of Ozempic, often due to dehydration. Some individuals may experience mild to moderate headaches during the initial stages of treatment. However, this side effect often diminishes over time as the body adjusts to the medication.

How long does it take for Ozempic to take effect?

Typically, the medication will start with a low dose of 0.25 mg once a week for four weeks. It may take about four to eight weeks to see the full effects of Ozempic.