Pancreatitis and Ozempic: Symptoms to Watch Out For

In the US, the leading causes of acute pancreatitis are gallstones, accounting for 35% to 40% of cases, and alcohol use, responsible for approximately 30% of cases. Drug-induced pancreatitis accounts for a smaller percentage, ranging from 0.1% to 2% of incidents. Most drug-related pancreatitis cases are mild to moderate in severity. However, potentially fatal cases can also occur.

Ozempic (semaglutide), classified as a glucagon-like peptide-1 receptor agonist (GLP-1 RA), is a medication prescribed to adults with type 2 diabetes. It has demonstrated efficacy in controlling blood sugar levels. However, reported cases have associated its use with pancreatitis, a condition marked by inflammation of the pancreas. This organ, located near the stomach, plays a crucial role in producing enzymes for digestion and hormones such as insulin, which help regulate levels of glucose in the bloodstream.

When the pancreas becomes inflamed, it can disrupt its normal function, leading to digestive problems and even life-threatening situations. In this article, we'll delve into what pancreatitis is, how Ozempic is related to it, and the symptoms you should be aware of.

Can Ozempic Lead To Pancreatitis?

As of now, there's no direct evidence proving Ozempic causes pancreatitis. There is a theory that the direct simulation of glucagon-like peptide-1 receptors in the pancreatic islets and exocrine duct cells can trigger excessive growth of the cells covering the smaller ducts within the pancreas.

This excessive growth can lead to chronic low-grade or acute inflammation. As a result, there is a concern that drugs that activate these receptors (like Ozempic) might increase the risk of pancreatitis and even pancreatic cancer. However, the evidence on this matter is controversial.

Source: CNN Health

In a study called SUSTAIN-6 involving patients from 230 sites across 20 countries, researchers looked at the effects of 0.5 or 1.0mg of semaglutide once weekly. This study was randomized, double-blind, and placebo-controlled.

The study found that subcutaneous semaglutide was associated with acute pancreatitis at rates similar to the placebo group. Additionally, all events were mild based on the revised Atlanta Classification of Acute Pancreatitis.

In studies examining how well Ozempic works for controlling blood sugar levels, one study that lasted for two years found that 8 out of every 100 patients treated with Ozempic had confirmed acute pancreatitis. Meanwhile, 10 out of every 100 patients treated with a placebo experienced the same outcome. Both were receiving standard care for their condition.

While some studies indicate an increased likelihood of acute pancreatitis with Ozempic use, no definitive evidence confirms a direct link. Furthermore, the medical director of the Tulane Bariatric Center, an expert in obesity medicine, told NBC News that rare side effects such as pancreatitis are less concerning to her than the health risks of obesity.

Top 3 Symptoms of Pancreatitis in Ozempic Users

Pancreatitis linked to GLP-1 RAs may not show the usual signs or symptoms that doctors expect to see. Hence, it could be more challenging to recognize or diagnose.

In addition to that, diabetic patients who are prescribed GLP-1 RA therapy often have other factors that increase their risk of getting acute pancreatitis, making it more complex to understand the actual risk.

To ensure patients are well-informed, here is a list of symptoms that manifest as potential side effects of Ozempic but may overlap with those of pancreatitis.

1. Severe Abdominal Pain

Pancreatitis manifests primarily through pain localized in the upper left side or center of the abdomen, often presenting distinct characteristics. Initially, this pain intensifies rapidly and may worsen after eating or drinking, particularly foods high in fat.

As the condition progresses, the pain becomes persistent and increasingly severe, lasting for several days. Moreover, it may exacerbate when lying flat on the back and can radiate to the back or below the left shoulder blade, further complicating its diagnosis and management.

2. Nausea and Vomiting

In a placebo-controlled trial, 20.3% of patients with Type 2 Diabetes Mellitus treated with 1mg of Ozempic reported experiencing nausea as a side effect.

Vomiting, though less prevalent at 9.2%, also occurred among participants. However, the onset of severe upper and middle abdominal pain in conjunction with these symptoms necessitates immediate medical attention, as it could signal pancreatitis.

3. Gas and Bloating

Ozempic causes food to take longer to digest in the stomach. This extended digestion process can result in increased gas production, leading to feelings of bloating and stomach discomfort.

Moreover, this side effect is also observed in patients with pancreatitis. As the pancreas loses its ability to produce digestive enzymes, digestion may be hindered, leading to gas buildup and contributing to bloating.

What Are Other Side Effects of Ozempic?

While Ozempic offers significant therapeutic benefits for individuals with Type 2 diabetes and obesity, it's essential to recognize potential side effects that may come with its use.

Find out about other possible side effects of Ozempic below.

• Diarrhea
• Constipation
• Swelling/redness/itching at the injection site
• Tiredness or fatigue
• Flatulence
• Burping (Ozempic burps)
• Changes to the face (Ozempic face)
• Hypoglycemia (Low blood glucose)
• Headache
• Gastroparesis (Stomach paralysis)
• Hair loss
• Increased heart rate
• Ileus (Temporary Intestinal Paralysis)
• Kidney problems
• Vision changes (Diabetic retinopathy)
• Gallbladder problems
• Trouble breathing
• Rebound weight gain
• Thyroid tumors
• Vivid dreams (Ozempic dreams)
• Dizziness
• Addictive and compulsive behavior relief

The list underscores the critical importance of seeking professional guidance and supervision when considering using Ozempic. By seeking professional guidance, individuals can navigate side effects more effectively and ensure that their treatment with Ozempic optimally addresses their health needs while minimizing risks.

Consequently, patients must maintain open communication with their healthcare providers, discuss any concerns, customize treatment plans, and receive necessary support throughout their journey with Ozempic.

Are There Any Ozempic Withdrawal Symptoms?

There are various reasons why individuals may choose to discontinue their use of Ozempic. This decision might stem from encountering adverse effects, transitioning to an alternative medication, or finding that their diabetes is effectively managed without it.

Similar to many medications, individuals who have been prescribed Ozempic for a prolonged period may encounter withdrawal symptoms upon cessation. These effects may include a notable increase in appetite.

These withdrawal symptoms may also manifest as:

• Increased thirst
• Frequent urination
• Blurred vision
• Headaches
• Nausea or vomiting

For individuals managing diabetes, discontinuing Ozempic can pose risks such as elevated blood sugar levels (hyperglycemia).

Experiencing these withdrawal symptoms can be uncomfortable and pose potential risks. However, there is a silver lining. Ozempic is associated with side effects that may be alleviated upon discontinuation of the medication. Patients may observe a reduction in:

• Headaches
• Joint and muscle pain
• Nausea
• Heartburn
• Diarrhea
• Facial sagging and wrinkles, commonly referred to as "Ozempic face"

Wrap-Up

Pancreatitis is a serious condition that necessitates immediate medical intervention. While Ozempic is an effective treatment for type 2 diabetes, it may be associated with an increased risk of pancreatitis. It's crucial for both patients and healthcare providers to recognize the symptoms of pancreatitis and to closely monitor them.

If you experience any symptoms suggestive of pancreatitis, especially while taking Ozempic, it's essential to seek medical attention promptly.

FAQs on Ozempic Pancreatitis Symptoms

When should I go to the hospital for Ozempic side effects?

Suppose you're experiencing severe side effects from Ozempic (semaglutide) or are unsure about the seriousness of your symptoms. In that case, it's essential to prioritize caution and promptly seek medical attention.

Are there any alternatives to Ozempic for managing type 2 diabetes?

Yes, several other medications are available for managing type 2 diabetes, including insulin, metformin, and other GLP-1 receptor agonists. Patients should cooperate with their healthcare provider to identify the most suitable treatment plan.

Can lifestyle changes help prevent pancreatitis?

Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding excessive alcohol consumption, can help reduce the risk of pancreatitis. However, some cases of pancreatitis may occur regardless of lifestyle factors.

How is pancreatitis diagnosed?

Pancreatitis is typically diagnosed through a combination of medical history, physical examination, and diagnostic tests such as blood tests. A blood test for the pancreas checks for increased levels of certain pancreatic enzymes in your bloodstream. If these levels are three times above the standard range, it may indicate pancreatitis. To confirm the diagnosis, your healthcare provider might recommend additional imaging tests like a CT scan or MRI.

What are the treatment options for pancreatitis?

In approximately 80% of individuals diagnosed with acute pancreatitis, the inflammation either resolves completely or shows significant improvement within a period of one to two weeks. Treatment for pancreatitis depends on the severity and underlying cause but may include medications for pain and inflammation, IV fluids, dietary changes, and in severe cases, hospitalization or surgery.